LOCUS BC136811 2155 bp mRNA linear HUM 11-FEB-2009
DEFINITION Homo sapiens neuregulin 3, mRNA (cDNA clone MGC:168424
IMAGE:9020801), complete cds.
ACCESSION BC136811
VERSION BC136811.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2155)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2155)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Ambion
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: LLDM Plate: 671 Row: h Column: 15
single stranded.
FEATURES Location/Qualifiers
source 1..2155
/db_xref="H-InvDB:HIT000500797"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:168424 IMAGE:9020801"
/tissue_type="Testicle, PCR rescued clones"
/clone_lib="NIH_MGC_382"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: ATCTTACG"
gene 1..2155
/gene="NRG3"
/gene_synonym="HRG3"
/gene_synonym="pro-NRG3"
/db_xref="GeneID:10718"
/db_xref="HGNC:HGNC:7999"
/db_xref="MIM:605533"
CDS 28..2115
/gene="NRG3"
/gene_synonym="HRG3"
/gene_synonym="pro-NRG3"
/codon_start=1
/product="neuregulin 3"
/protein_id="AAI36812.1"
/db_xref="GeneID:10718"
/db_xref="HGNC:HGNC:7999"
/db_xref="MIM:605533"
/translation="MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEG
AAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDL
VDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTT
ITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPST
QAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHT
TTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPK
TDSILSDPNHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQ
EQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGP
QSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPA
YQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYS
STRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQ
EVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFV
LRNEIQRDSALTK"
BASE COUNT 542 a 646 c 535 g 432 t
ORIGIN
1 gggcgaaggt gaagaccggc tcctaggatg agtgaagggg cggccgctgc ctcgccacct
61 ggtgccgctt cggcagccgc cgcctcggcc gaggagggca ccgcggcggc tgcggcggcg
121 gcagcggcgg gcgggggccc ggacggcggc ggcgaagggg cggccgagcc cccccgggag
181 ttacgctgta gcgactgcat cgtgtggaac cggcagcaga cgtggctgtg cgtggtacct
241 ctgttcatcg gcttcatcgg cctggggctc agcctcatgc ttctcaaatg gatcgtggtg
301 ggctccgtca aggagtacgt gcccaccgac ctagtggact ccaaggggat gggccaggac
361 cccttcttcc tctccaagcc cagctctttc cccaaggcca tggagaccac caccactacc
421 acttccacca cgtcccccgc caccccctcc gccgggggtg ccgcctcctc caggacgccc
481 aaccggatta gcactcgcct gaccaccatc acgcgggcgc ccactcgctt ccccgggcac
541 cgggtgccca tccgggccag cccgcgctcc accacagcac ggaacactgc ggcccctgcg
601 acggtcccgt ccaccacggc cccgttcttc agtagcagca cgctgggctc ccgacccccg
661 gtgccaggaa ctccaagtac ccaggcaatg ccctcctggc ctactgcggc atacgctacc
721 tcctcctacc ttcacgattc tactccctcc tggaccctgt ctccctttca ggatgctgcc
781 tcctcttctt cctcttcttc ctcctccgct accaccacca caccagaaac tagcaccagc
841 cccaaatttc atacgacgac atattccaca gagcgatccg agcacttcaa accctgccga
901 gacaaggacc ttgcatactg tctcaatgat ggcgagtgct ttgtgatcga aaccctgacc
961 ggatcccata aacactgtcg gtgcaaagaa ggctaccaag gagtccgttg tgatcaattt
1021 ctgccgaaaa ctgattccat cttatcggat ccaaaccact tggggattga attcatggag
1081 agtgaagaag tttatcaaag gcaggtgctg tcaatttcat gtatcatctt tggaattgtc
1141 atcgtgggca tgttctgtgc agcattctac ttcaaaagca agaaacaagc taaacaaatc
1201 caagagcagc tgaaagtgcc acaaaatggt aaaagctaca gtctcaaagc atccagcaca
1261 atggcaaagt cagagaactt ggtgaagagc catgtccagc tgcaaaatta ttcaaaggtg
1321 gaaaggcatc ctgtgactgc attggagaaa atgatggagt caagttttgt cggcccccag
1381 tcattccctg aggtcccttc tcctgacaga ggaagccagt ctgtcaaaca ccacaggagt
1441 ctatcctctt gctgcagccc agggcaaaga agtggcatgc tccataggaa tgccttcaga
1501 aggacacccc cgtcaccccg aagtaggcta ggtggaattg tgggaccagc atatcagcaa
1561 ctcgaagaat caaggatccc agaccaggat acgatacctt gccaagggta ttcatccagt
1621 ggtttaaaaa cccaacgaaa tacatcaata aatatgcaac tgccttcaag agagacaaac
1681 ccctatttta atagcttgga gcaaaaggac ctggtgggct attcatccac aagggccagt
1741 tctgtgccca tcatcccttc agtgggttta gaggaaacct gcctgcaaat gccagggatt
1801 tctgaagtca aaagcatcaa atggtgcaaa aactcctatt cagctgacgt tgtcaatgtg
1861 agtattccag tcagcgattg tcttatagca gaacaacaag aagtgaaaat attgctagaa
1921 actgtccagg agcagatccg aattctgact gatgccagac ggtcagaaga ctacgaactg
1981 gccagcgtag aaaccgagga cagtgcaagc gaaaacacag cctttctccc cctgagtccc
2041 acagccaaat cagaacgaga ggcgcaattt gtcttaagaa atgaaataca aagagactct
2101 gcattgacca agtgacttga gatgtaggaa tctgtgcatt ctatgctttg ctcaa
//