LOCUS       BC136440                4309 bp    mRNA    linear   HUM 11-FEB-2009
DEFINITION  Homo sapiens 5-methyltetrahydrofolate-homocysteine
            methyltransferase, mRNA (cDNA clone MGC:168052 IMAGE:9020429),
            complete cds.
ACCESSION   BC136440
VERSION     BC136440.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 4309)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2007) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Ambion
            cDNA Library Preparation: British Columbia Cancer Research Center
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: LLDM Plate: 670 Row: i Column: 3
            single stranded.
FEATURES             Location/Qualifiers
     source          1..4309
                     /db_xref="H-InvDB:HIT000500459"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:168052 IMAGE:9020429"
                     /tissue_type="Testicle, PCR rescued clones"
                     /clone_lib="NIH_MGC_382"
                     /lab_host="DH10B"
                     /note="Vector: pCR4-TOPO with reversed insert; Clone
                     identification sequence tag: TTCTAACG"
     gene            1..4309
                     /gene="MTR"
                     /gene_synonym="cblG"
                     /gene_synonym="MS"
                     /db_xref="GeneID:4548"
                     /db_xref="HGNC:HGNC:7468"
                     /db_xref="MIM:156570"
     CDS             23..3820
                     /gene="MTR"
                     /gene_synonym="cblG"
                     /gene_synonym="MS"
                     /codon_start=1
                     /product="5-methyltetrahydrofolate-homocysteine
                     methyltransferase"
                     /protein_id="AAI36441.1"
                     /db_xref="GeneID:4548"
                     /db_xref="HGNC:HGNC:7468"
                     /db_xref="MIM:156570"
                     /translation="MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQRE
                     KLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTS
                     IAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVE
                     RPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYA
                     PRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGK
                     CTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREI
                     AEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMA
                     GNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS
                     SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATE
                     TDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKE
                     TLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIH
                     KELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKG
                     IEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVM
                     KKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGC
                     NNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPL
                     LIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYE
                     DIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDY
                     IDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARG
                     VVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAP
                     LHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVR
                     RELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLT
                     ESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGY
                     DTD"
BASE COUNT         1216 a          904 c         1109 g         1080 t
ORIGIN      
        1 cgcaaggagg agactcgaca acatgtcacc cgcgctccaa gacctgtcgc aacccgaagg
       61 tctgaagaaa accctgcggg atgagatcaa tgccattctg cagaagagga ttatggtgct
      121 ggatggaggg atggggacca tgatccagcg ggagaagcta aacgaagaac acttccgagg
      181 tcaggaattt aaagatcatg ccaggccgct gaaaggcaac aatgacattt taagtataac
      241 tcagcctgat gtcatttacc aaatccataa ggaatacttg ctggctgggg cagatatcat
      301 tgaaacaaat acttttagca gcactagtat tgcccaagct gactatggcc ttgaacactt
      361 ggcctaccgg atgaacatgt gctctgcagg agtggccaga aaagctgccg aggaggtaac
      421 tctccagaca ggaattaaga ggtttgtggc aggggctctg ggtccgacta ataagacact
      481 ctctgtgtcc ccatctgtgg aaaggccgga ttataggaac atcacatttg atgagcttgt
      541 tgaagcatac caagagcagg ccaaaggact tctggatggc ggggttgata tcttactcat
      601 tgaaactatt tttgatactg ccaatgccaa ggcagccttg tttgcactcc aaaatctttt
      661 tgaggagaaa tatgctcccc ggcctatctt tatttcaggg acgatcgttg ataaaagtgg
      721 gcggactctt tccggacaga caggagaggg atttgtcatc agcgtgtctc atggagaacc
      781 actctgcatt ggattaaatt gtgctttggg tgcagctgaa atgagacctt ttattgaaat
      841 aattggaaaa tgtacaacag cctatgtcct ctgttatccc aatgcaggtc ttcccaacac
      901 ctttggtgac tatgatgaaa cgccttctat gatggccaag cacctaaagg attttgctat
      961 ggatggcttg gtcaatatag ttggaggatg ctgtgggtca acaccagatc atatcaggga
     1021 aattgctgaa gctgtgaaaa attgtaagcc tagagttcca cctgccactg cttttgaagg
     1081 acatatgtta ctgtctggtc tagagccctt caggattgga ccgtacacca actttgttaa
     1141 cattggagag cgctgtaatg ttgcaggatc aaggaagttt gctaaactca tcatggcagg
     1201 aaactatgaa gaagccttgt gtgttgccaa agtgcaggtg gaaatgggag cccaggtgtt
     1261 ggatgtcaac atggatgatg gcatgctaga tggtccaagt gcaatgacca gattttgcaa
     1321 cttaattgct tccgagccag acatcgcaaa ggtacctttg tgcatcgact cctccaattt
     1381 tgctgtgatt gaagctgggt taaagtgctg ccaagggaag tgcattgtca atagcattag
     1441 tctgaaggaa ggagaggacg acttcttgga gaaggccagg aagattaaaa agtatggagc
     1501 tgctatggtg gtcatggctt ttgatgaaga aggacaggca acagaaacag acacaaaaat
     1561 cagagtgtgc acccgggcct accatctgct tgtgaaaaaa ctgggcttta atccaaatga
     1621 cattattttt gaccctaata tcctaaccat tgggactgga atggaggaac acaacttgta
     1681 tgccattaat tttatccatg caacaaaagt cattaaagaa acattacctg gagccagaat
     1741 aagtggaggt ctttccaact tgtccttctc cttccgagga atggaagcca ttcgagaagc
     1801 aatgcatggg gttttccttt accatgcaat caagtctggc atggacatgg ggatagtgaa
     1861 tgctggaaac ctccctgtgt atgatgatat ccataaggaa cttctgcagc tctgtgaaga
     1921 tctcatctgg aataaagacc ctgaggccac tgagaagctc ttacgttatg cccagactca
     1981 aggcacagga gggaagaaag tcattcagac tgatgagtgg agaaatggcc ctgtcgaaga
     2041 acgccttgag tatgcccttg tgaagggcat tgaaaaacat attattgagg atactgagga
     2101 agccaggtta aaccaaaaaa aatatccccg acctctcaat ataattgaag gacccctgat
     2161 gaatggaatg aaaattgttg gtgatctttt tggagctgga aaaatgtttc tacctcaggt
     2221 tataaagtca gcccgggtta tgaagaaggc tgttggccac cttatccctt tcatggaaaa
     2281 agaaagagaa gaaaccagag tgcttaacgg cacagtagaa gaagaggacc cttaccaggg
     2341 caccatcgtg ctggccactg ttaaaggcga cgtgcacgac ataggcaaga acatagttgg
     2401 agtagtcctt ggctgcaata atttccgagt tattgattta ggagtcatga ctccatgtga
     2461 taagatactg aaagctgctc ttgaccacaa agcagatata attggcctgt caggactcat
     2521 cactccttcc ctggatgaaa tgatttttgt tgccaaggaa atggagagat tagctataag
     2581 gattccattg ttgattggag gagcaaccac ttcaaaaacc cacacagcag ttaaaatagc
     2641 tccgagatac agtgcacctg taatccatgt cctggacgcg tccaagagtg tggtggtgtg
     2701 ttcccagctg ttagatgaaa atctaaagga tgaatacttt gaggaaatca tggaagaata
     2761 tgaagatatt agacaggacc attatgagtc tctcaaggag aggagatact tacccttaag
     2821 tcaagccaga aaaagtggtt tccaaatgga ttggctgtct gaacctcacc cagtgaagcc
     2881 cacgtttatt gggacccagg tctttgaaga ctatgacctg cagaagctgg tggactacat
     2941 tgactggaag cctttctttg atgtctggca gctccggggc aagtacccga atcgaggctt
     3001 tcccaagata tttaacgaca aaacagtagg tggagaggcc aggaaggtct acgatgatgc
     3061 ccacaatatg ctgaacacac tgattagtca aaagaaactc cgggcccggg gtgtggttgg
     3121 gttctggcca gcacagagta tccaagacga cattcacctg tacgcagagg ctgctgtgcc
     3181 ccaggctgca gagcccatag ccaccttcta tgggttaagg caacaggctg agaaggactc
     3241 tgccagcacg gagccatact actgcctctc agacttcatc gctcccttgc attctggcat
     3301 ccgtgactac ctgggcctgt ttgccgttgc ctgctttggg gtagaagagc tgagcaaggc
     3361 ctatgaggat gatggtgacg actacagcag catcatggtc aaggcgctgg gggaccggct
     3421 ggcagaggcc tttgcagaag agctccatga aagagttcgc cgagaactgt gggcctactg
     3481 tggcagtgag cagctggacg tcgcagacct gcgcaggctg cggtacaagg gcatccgccc
     3541 ggctcctggc taccccagcc agcccgacca caccgagaag ctcaccatgt ggagactcgc
     3601 agacatcgag cagtctacag gcattaggtt aacagaatca ttagcaatgg cacctgcttc
     3661 agcagtctca ggcctctact tctccaattt gaagtccaaa tattttgctg tggggaagat
     3721 ttccaaggat caggttgagg attatgcatt gaggaagaac atatctgtgg ctgaggttga
     3781 gaaatggctt ggacccattt tgggatatga tacagactaa cttttttttt tttttgcctt
     3841 ttttattctt gatgatcctc aaggaaatac aacctagggt gccttaaaaa taacaacaac
     3901 aaaaaacctg tgtgcatctg gctgacactt acctgcttct ggttttcgaa gactatttag
     3961 tggaaccttg tagaggagca gggtcttcct gcagtgcctg gaaaacaggc gctgtttttt
     4021 tgggaccttg cgtgaagagc agtgagcagg gttcctgtgg tttccctggt ccctctgaga
     4081 tggggacaga ctgaagacag aggtcgtttg atttcaaagc aagtcaacct gcttttttct
     4141 gtttttacag tggaatctag gaggccactt agtcgtcttt ttttcctctt agaagaaaag
     4201 cctgaaactg agttgaatag agaagtgtga ccctgtgaca aaatgatact gtgagaaatg
     4261 gggcatttta atctaagtgg ttataacagt ggattctgac ggggaaggt
//