LOCUS BC132919 3873 bp mRNA linear HUM 06-DEC-2007
DEFINITION Homo sapiens phosphoinositide-3-kinase, catalytic, delta
polypeptide, mRNA (cDNA clone MGC:164550 IMAGE:40146941), complete
cds.
ACCESSION BC132919
VERSION BC132919.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3873)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3873)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 9 Row: K Column: 13.
FEATURES Location/Qualifiers
source 1..3873
/db_xref="H-InvDB:HIT000390970"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:164550 IMAGE:40146941"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_362"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: TTTAGGTC"
gene 1..3873
/gene="PIK3CD"
/gene_synonym="p110D"
/db_xref="GeneID:5293"
/db_xref="HGNC:HGNC:8977"
/db_xref="MIM:602839"
CDS 123..3257
/gene="PIK3CD"
/gene_synonym="p110D"
/codon_start=1
/product="phosphoinositide-3-kinase, catalytic, delta
polypeptide"
/protein_id="AAI32920.1"
/db_xref="GeneID:5293"
/db_xref="HGNC:HGNC:8977"
/db_xref="MIM:602839"
/translation="MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLST
IKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLV
AREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWE
AWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMA
CALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTM
VHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVN
ADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCF
ALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
ELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQ
LQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLY
LLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY
LDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVL
MKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTL
LAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMD
VLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALL
NWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH
FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGL
LFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTK
VNWLAHNVSKDNRQ"
BASE COUNT 807 a 1184 c 1127 g 755 t
ORIGIN
1 agggcgggat gacactcatt gattctaaag catctttaat ctgccaggcg gagggggctt
61 tgctggtctt tcttggacta ttccagagag gacaactgtc atctgggaag taacaacgca
121 ggatgccccc tggggtggac tgccccatgg aattctggac caaggaggag aatcagagcg
181 ttgtggttga cttcctgctg cccacagggg tctacctgaa cttccctgtg tcccgcaatg
241 ccaacctcag caccatcaag cagctgctgt ggcaccgcgc ccagtatgag ccgctcttcc
301 acatgctcag tggccccgag gcctatgtgt tcacctgcat caaccagaca gcggagcagc
361 aagagctgga ggacgagcaa cggcgtctgt gtgacgtgca gcccttcctg cccgtcctgc
421 gcctggtggc ccgtgagggc gaccgcgtga agaagctcat caactcacag atcagcctcc
481 tcatcggcaa aggcctccac gagtttgact ccttgtgcga cccagaagtg aacgactttc
541 gcgccaagat gtgccaattc tgcgaggagg cggccgcccg ccggcagcag ctgggctggg
601 aggcctggct gcagtacagt ttccccctgc agctggagcc ctcggctcaa acctgggggc
661 ctggtaccct gcggctcccg aaccgggccc ttctggtcaa cgttaagttt gagggcagcg
721 aggagagctt caccttccag gtgtccacca aggacgtgcc gctggcgctg atggcctgtg
781 ccctgcggaa gaaggccaca gtgttccggc agccgctggt ggagcagccg gaagactaca
841 cgctgcaggt gaacggcagg catgagtacc tgtatggcag ctacccgctc tgccagttcc
901 agtacatctg cagctgcctg cacagtgggt tgacccctca cctgaccatg gtccattcct
961 cctccatcct cgccatgcgg gatgagcaga gcaaccctgc cccccaggtc cagaaaccgc
1021 gtgccaaacc acctcccatt cctgcgaaga agccttcctc tgtgtccctg tggtccctgg
1081 agcagccgtt ccgcatcgag ctcatccagg gcagcaaagt gaacgccgac gagcggatga
1141 agctggtggt gcaggccggg cttttccacg gcaacgagat gctgtgcaag acggtgtcca
1201 gctcggaggt gagcgtgtgc tcggagcccg tgtggaagca gcggctggag ttcgacatca
1261 acatctgcga cctgccccgc atggcccgtc tctgctttgc gctgtacgcc gtgatcgaga
1321 aagccaagaa ggctcgctcc accaagaaga agtccaagaa ggcggactgc cccattgcct
1381 gggccaacct catgctgttt gactacaagg accagcttaa gaccggggaa cgctgcctct
1441 acatgtggcc ctccgtccca gatgagaagg gcgagctgct gaaccccacg ggcactgtgc
1501 gcagtaaccc caacacggat agcgccgctg ccctgctcat ctgcctgccc gaggtggccc
1561 cgcaccccgt gtactacccc gccctggaga agatcttgga gctggggcga cacagcgagt
1621 gtgtgcatgt caccgaggag gagcagctgc agctgcggga aatcctggag cggcgggggt
1681 ctggggagct gtatgagcac gagaaggacc tggtgtggaa gctgcggcat gaagtccagg
1741 agcacttccc ggaggcgcta gcccggctgc tgctggtcac caagtggaac aagcatgagg
1801 atgtggccca gatgctctac ctgctgtgct cctggccgga gctgcccgtc ctgagcgccc
1861 tggagctgct agacttcagc ttccccgatt gccacgtagg ctccttcgcc atcaagtcgc
1921 tgcggaaact gacggacgat gagctgttcc agtacctgct gcagctggtg caggtgctca
1981 agtacgagtc ctacctggac tgcgagctga ccaaattcct gctggaccgg gccctggcca
2041 accgcaagat cggccacttc cttttctggc acctccgctc cgagatgcac gtgccgtcgg
2101 tggccctgcg cttcggcctc atcctggagg cctactgcag gggcagcacc caccacatga
2161 aggtgctgat gaagcagggg gaagcactga gcaaactgaa ggccctgaat gacttcgtca
2221 agctgagctc tcagaagacc cccaagcccc agaccaagga gctgatgcac ttgtgcatgc
2281 ggcaggaggc ctacctagag gccctctccc acctgcagtc cccactcgac cccagcaccc
2341 tgctggctga agtctgcgtg gagcagtgca ccttcatgga ctccaagatg aagcccctgt
2401 ggatcatgta cagcaacgag gaggcaggca gcggcggcag cgtgggcatc atctttaaga
2461 acggggatga cctccggcag gacatgctga ccctgcagat gatccagctc atggacgtcc
2521 tgtggaagca ggaggggctg gacctgagga tgacccccta tggctgcctc cccaccgggg
2581 accgcacagg cctcattgag gtggtactcc gttcagacac catcgccaac atccaactca
2641 acaagagcaa catggcagcc acagccgcct tcaacaagga tgccctgctc aactggctga
2701 agtccaagaa cccgggggag gccctggatc gagccattga ggagttcacc ctctcctgtg
2761 ctggctattg tgtggccaca tatgtgctgg gcattggcga tcggcacagc gacaacatca
2821 tgatccgaga gagtgggcag ctgttccaca ttgattttgg ccactttctg gggaatttca
2881 agaccaagtt tggaatcaac cgcgagcgtg tcccattcat cctcacctac gactttgtcc
2941 atgtgattca gcaggggaag actaataata gtgagaaatt tgaacggttc cggggctact
3001 gtgaaagggc ctacaccatc ctgcggcgcc acgggcttct cttcctccac ctctttgccc
3061 tgatgcgggc ggcaggcctg cctgagctca gctgctccaa agacatccag tatctcaagg
3121 actccctggc actggggaaa acagaggagg aggcactgaa gcacttccga gtgaagttta
3181 acgaagccct ccgtgagagc tggaaaacca aagtgaactg gctggcccac aacgtgtcca
3241 aagacaacag gcagtagtgg ctcctcccag ccctgggccc aagaggaggc ggctgcgggt
3301 cgtggggacc aagcacattg gtcctaaagg ggctgaagag cctgaactgc acctaacggg
3361 aaagaaccga catggctgcc ttttgtttac actggttatt tatttatgac ttgaaatagt
3421 ttaaggagct aaacagccat aaacggaaac gcctccttca tgcagcggcg gtgctgggcc
3481 ccccgaggct gcacctggct ctcggctgag gattgtcacc ccaagtcttc cagctggtgg
3541 atctgggccc agcaaagact gttctcctcc cgagggaacc ttcttcccag gcctcccgcc
3601 agactgcctg ggtcctggcg cctggcggtc acctggtgcc tactgtccga caggatgcct
3661 cgatcctcgt gcgacccacc ctgtgtatcc tccctagact gagttctggc agctccccga
3721 ggcagccggg gtaccctcta gattcaggga tgcttgctct ccacttttca agtgggtctt
3781 gggtacgaga attccctcat ctttctctac tgtaaagtga ttttgtttgc aggtaagaaa
3841 ataatagatg actcaccaca cctctacggc tgg
//