LOCUS BC132684 1718 bp mRNA linear HUM 06-DEC-2007
DEFINITION Homo sapiens interleukin 6 receptor, mRNA (cDNA clone MGC:164315
IMAGE:40146706), complete cds.
ACCESSION BC132684
VERSION BC132684.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1718)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1718)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 9 Row: A Column: 18.
FEATURES Location/Qualifiers
source 1..1718
/db_xref="H-InvDB:HIT000390739"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:164315 IMAGE:40146706"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_361"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO; Clone identification sequence
tag: AGCTGAGC"
gene 1..1718
/gene="IL6R"
/gene_synonym="CD126"
/gene_synonym="IL-6R-1"
/gene_synonym="IL-6R-alpha"
/gene_synonym="IL6RA"
/db_xref="GeneID:3570"
/db_xref="HGNC:HGNC:6019"
/db_xref="MIM:147880"
CDS 251..1657
/gene="IL6R"
/gene_synonym="CD126"
/gene_synonym="IL-6R-1"
/gene_synonym="IL-6R-alpha"
/gene_synonym="IL6RA"
/codon_start=1
/product="interleukin 6 receptor"
/protein_id="AAI32685.1"
/db_xref="GeneID:3570"
/db_xref="HGNC:HGNC:6019"
/db_xref="MIM:147880"
/translation="MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVT
LTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRP
AGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAED
FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDP
PANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHH
CVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQAL
TTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTW
KLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA
RDPRSPYDISNTDYFFPR"
BASE COUNT 342 a 536 c 523 g 317 t
ORIGIN
1 tgagtcatgt gcgagtggga agtcgcactg acactgagcc gggccagagg gagaggagcc
61 gagcgcggcg cggggccgag ggactcgcag tgtgtgtaga gagccgggct cctgcggatg
121 ggggctgccc ccggggcctg agcccgcctg cccgcccacc gccccgcccc gcccctgcca
181 cccctgccgc ccggttccca ttagcctgtc cgcctctgcg ggaccatgga gtggtagccg
241 aggaggaagc atgctggccg tcggctgcgc gctgctggct gccctgctgg ccgcgccggg
301 agcggcgctg gccccaaggc gctgccctgc gcaggaggtg gcgagaggcg tgctgaccag
361 tctgccagga gacagcgtga ctctgacctg cccgggggta gagccggaag acaatgccac
421 tgttcactgg gtgctcagga agccggctgc aggctcccac cccagcagat gggctggcat
481 gggaaggagg ctgctgctga ggtcggtgca gctccacgac tctggaaact attcatgcta
541 ccgggccggc cgcccagctg ggactgtgca cttgctggtg gatgttcccc ccgaggagcc
601 ccagctctcc tgcttccgga agagccccct cagcaatgtt gtttgtgagt ggggtcctcg
661 gagcacccca tccctgacga caaaggctgt gctcttggtg aggaagtttc agaacagtcc
721 ggccgaagac ttccaggagc cgtgccagta ttcccaggag tcccagaagt tctcctgcca
781 gttagcagtc ccggagggag acagctcttt ctacatagtg tccatgtgcg tcgccagtag
841 tgtcgggagc aagttcagca aaactcaaac ctttcagggt tgtggaatct tgcagcctga
901 tccgcctgcc aacatcacag tcactgccgt ggccagaaac ccccgctggc tcagtgtcac
961 ctggcaagac ccccactcct ggaactcatc tttctacaga ctacggtttg agctcagata
1021 tcgggctgaa cggtcaaaga cattcacaac atggatggtc aaggacctcc agcatcactg
1081 tgtcatccac gacgcctgga gcggcctgag gcacgtggtg cagcttcgtg cccaggagga
1141 gttcgggcaa ggcgagtgga gcgagtggag cccggaggcc atgggcacgc cttggacaga
1201 atccaggagt cctccagctg agaacgaggt gtccaccccc atgcaggcac ttactactaa
1261 taaagacgat gataatattc tcttcagaga ttctgcaaat gcgacaagcc tcccagtgca
1321 agattcttct tcagtaccac tgcccacatt cctggttgct ggagggagcc tggccttcgg
1381 aacgctcctc tgcattgcca ttgttctgag gttcaagaag acgtggaagc tgcgggctct
1441 gaaggaaggc aagacaagca tgcatccgcc gtactctttg gggcagctgg tcccggagag
1501 gcctcgaccc accccagtgc ttgttcctct catctcccca ccggtgtccc ccagcagcct
1561 ggggtctgac aatacctcga gccacaaccg accagatgcc agggacccac ggagccctta
1621 tgacatcagc aatacagact acttcttccc cagatagctg gctgggtggc accagcagcc
1681 tggaccctgt ggatgataaa acacaaacgg gctcagca
//