LOCUS BC131778 3473 bp mRNA linear HUM 30-JAN-2007
DEFINITION Homo sapiens dihydropyrimidine dehydrogenase, mRNA (cDNA clone
MGC:156280 IMAGE:40123878), complete cds.
ACCESSION BC131778
VERSION BC131778.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3473)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3473)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-JAN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 30 Row: o Column: 16.
FEATURES Location/Qualifiers
source 1..3473
/db_xref="H-InvDB:HIT000390679"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:156280 IMAGE:40123878"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_283"
/note="Vector: pCR-Blunt II-TOPO with reversed insert;
Clone identification sequence tag: TAACCTTT sequenced from
the forward primer"
gene 1..3473
/gene="DPYD"
/gene_synonym="DHP"
/gene_synonym="DPD"
/db_xref="GeneID:1806"
/db_xref="HGNC:HGNC:3012"
/db_xref="MIM:274270"
CDS 54..3131
/gene="DPYD"
/gene_synonym="DHP"
/gene_synonym="DPD"
/codon_start=1
/product="dihydropyrimidine dehydrogenase"
/protein_id="AAI31779.1"
/db_xref="GeneID:1806"
/db_xref="HGNC:HGNC:3012"
/db_xref="MIM:274270"
/translation="MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRN
PDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFIT
SIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFAT
EVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFE
KQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGY
KAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGV
VIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLS
PRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEA
LSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQ
SQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEA
GWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQS
VTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGL
ACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGITATNTVSG
LMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDS
AESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPAT
VSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIP
KRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQ
FDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPGC"
BASE COUNT 997 a 705 c 809 g 962 t
ORIGIN
1 tgaggacgca aggagggttt gtcactggca gactcgagac tgtaggcact gccatggccc
61 ctgtgctcag taaggactcg gcggacatcg agagtatcct ggctttaaat cctcgaacac
121 aaactcatgc aactctgtgt tccacttcgg ccaagaaatt agacaagaaa cattggaaaa
181 gaaatcctga taagaactgc tttaattgtg agaagctgga gaataatttt gatgacatca
241 agcacacgac tcttggtgag cgaggagctc tccgagaagc aatgagatgc ctgaaatgtg
301 cagatgcccc gtgtcagaag agctgtccaa ctaatcttga tattaaatca ttcatcacaa
361 gtattgcaaa caagaactat tatggagctg ctaagatgat attttctgac aacccacttg
421 gtctgacttg tggaatggta tgtccaacct ctgatctttg tgtaggtgga tgcaatttat
481 atgccactga agagggaccc attaatattg gtggattgca gcaatttgct actgaggtat
541 tcaaagcaat gagtatccca cagatcagaa atccttcgct gcctccccca gaaaaaatgt
601 ctgaagccta ttctgcaaag attgctcttt ttggtgctgg gcctgcaagt ataagttgtg
661 cttccttttt ggctcgattg gggtactctg acatcactat atttgaaaaa caagaatatg
721 ttggtggttt aagtacttct gaaattcctc agttccggct gccgtatgat gtagtgaatt
781 ttgagattga gctaatgaag gaccttggtg taaagataat ttgcggtaaa agcctttcag
841 tgaatgaaat gactcttagc actttgaaag aaaaaggcta caaagctgct ttcattggaa
901 taggtttgcc agaacccaat aaagatgcca tcttccaagg cctgacgcag gaccaggggt
961 tttatacatc caaagacttt ttgccacttg tagccaaagg cagtaaagca ggaatgtgcg
1021 cctgtcactc tccattgcca tcgatacggg gagtcgtgat tgtacttgga gctggagaca
1081 ctgcctttga ctgtgcaaca tctgctctac gttgtggagc tcgccgtgtg ttcatcgtct
1141 tcagaaaagg ctttgttaat ataagagctg tccctgagga gatggaactt gctaaggaag
1201 aaaagtgtga atttctgcca ttcctgtccc cacggaaggt tatagtaaaa ggtgggagaa
1261 ttgttgctat gcagtttgtt cggacagagc aagatgaaac tggaaaatgg aatgaagatg
1321 aagatcagat ggtccatctg aaagccgatg tggtcatcag tgcctttggt tcagttctga
1381 gtgatcctaa agtaaaagaa gccttgagcc ctataaaatt taacagatgg ggtctcccag
1441 aagtagatcc agaaactatg caaactagtg aagcatgggt atttgcaggt ggtgatgtcg
1501 ttggtttggc taacactaca gtggaatcgg tgaatgatgg aaagcaagct tcttggtaca
1561 ttcacaaata cgtacagtca caatatggag cttccgtttc tgccaagcct gaactacccc
1621 tcttttacac tcctattgat ctggtggaca ttagtgtaga aatggccgga ttgaagttta
1681 taaatccttt tggtcttgct agcgcaactc cagccaccag cacatcaatg attcgaagag
1741 cttttgaagc tggatggggt tttgccctca ccaaaacttt ctctcttgat aaggacattg
1801 tgacaaatgt ttcccccaga atcatccggg gaaccacctc tggccccatg tatggccctg
1861 gacaaagctc ctttctgaat attgagctca tcagtgagaa aacggctgca tattggtgtc
1921 aaagtgtcac tgaactaaag gctgactttc cagacaacat tgtgattgct agcattatgt
1981 gcagttacaa taaaaatgac tggacggaac ttgccaagaa gtctgaggat tctggagcag
2041 atgccctgga gttaaattta tcatgtccac atggcatggg agaaagagga atgggcctgg
2101 cctgtgggca ggatccagag ctggtgcgga acatctgccg ctgggttagg caagctgttc
2161 agattccttt ttttgccaag ctgaccccaa atgtcactga tattgtgagc atcgcaagag
2221 ctgcaaagga aggtggtgcc aatggcatta cagccaccaa cactgtctca ggtctgatgg
2281 gattaaaatc tgatggcaca ccttggccag cagtggggat tgcaaagcga actacatatg
2341 gaggagtgtc tgggacagca atcagaccta ttgctttgag agctgtgacc tccattgctc
2401 gtgctctgcc tggatttccc attttggcta ctggtggaat tgactctgct gaaagtggtc
2461 ttcagtttct ccatagtggt gcttccgtcc tccaggtatg cagtgccatt cagaatcagg
2521 atttcactgt gatcgaagac tactgcactg gcctcaaagc cctgctttat ctgaaaagca
2581 ttgaagaact acaagactgg gatggacaga gtccagctac tgtgagtcac cagaaaggga
2641 aaccagttcc acgtatagct gaactcatgg acaagaaact gccaagtttt ggaccttatc
2701 tggaacagcg caagaaaatc atagcagaaa acaagattag actgaaagaa caaaatgtag
2761 ctttttcacc acttaagaga aactgtttta tccccaaaag gcctattcct accatcaagg
2821 atgtaatagg aaaagcactg cagtaccttg gaacatttgg tgaattgagc aacgtagagc
2881 aagttgtggc tatgattgat gaagaaatgt gtatcaactg tggtaaatgc tacatgacct
2941 gtaatgattc tggctaccag gctatacagt ttgatccaga aacccacctg cccaccataa
3001 ccgacacttg tacaggctgt actctgtgtc tcagtgtttg ccctattgtc gactgcatca
3061 aaatggtttc caggacaaca ccttatgaac caaagagagg cgtaccctta tctgtgaatc
3121 cggggtgtta aggtgatttg tgaaacagtt gctgtgaact ttcatgtcac ctacatatgc
3181 tgatctttta aaatcatgat ccttgtgttc agctctttcc aaattaaaac aaatatacat
3241 tttctaaata aaaatatgta atttcaaaat acatttgtaa gtgtaaaaaa tgtctcatgt
3301 caatgaccat tcaattagtg gtcataaaat agaataattc ttttctgagg atagtagtta
3361 aataactgtg tggcagttaa ttggatgttc actgccagtt gtcttatgtg aaaaattaac
3421 ttttttgtgg caattagtgt gacagtttcc aaattgccct atgctgtgct cca
//