LOCUS BC131733 4622 bp mRNA linear HUM 30-JAN-2007
DEFINITION Homo sapiens ADAM metallopeptidase with thrombospondin type 1
motif, 12, mRNA (cDNA clone MGC:150699 IMAGE:40124828), complete
cds.
ACCESSION BC131733
VERSION BC131733.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4622)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4622)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-JAN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 31 Row: p Column: 19.
FEATURES Location/Qualifiers
source 1..4622
/db_xref="H-InvDB:HIT000390635"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:150699 IMAGE:40124828"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_283"
/note="Vector: pCR-Blunt II-TOPO with reversed insert;
Clone identification sequence tag: GGTTTTCT sequenced from
the forward primer"
gene 1..4622
/gene="ADAMTS12"
/gene_synonym="PRO4389"
/db_xref="GeneID:81792"
/db_xref="HGNC:HGNC:14605"
/db_xref="MIM:606184"
CDS 86..4615
/gene="ADAMTS12"
/gene_synonym="PRO4389"
/codon_start=1
/product="ADAMTS12 protein"
/protein_id="AAI31734.1"
/db_xref="GeneID:81792"
/db_xref="HGNC:HGNC:14605"
/db_xref="MIM:606184"
/translation="MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEH
FIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDL
FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSAC
HGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQ
KQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMN
MVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDL
NPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAH
ELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGF
CLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCR
SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAE
RLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWF
PIFNPGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKL
AGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQM
YFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACP
PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRD
ILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSS
RRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTAS
KEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTS
EGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESN
PVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSET
GTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEED
ATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSD
CAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHC
QFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTS
TMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPP
EFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHITRT
QRQRRQRLLQKSKEL"
BASE COUNT 1234 a 1213 c 1216 g 959 t
ORIGIN
1 tcctgctggg ccacaggcga gcgctttatt tctggagctg agggctaaaa cttttttgac
61 ttttcttctc ctcaacatct gaatcatgcc atgtgcccag aggagctggc ttgcaaacct
121 ttccgtggtg gctcagctcc ttaactttgg ggcgctttgc tatgggagac agcctcagcc
181 aggcccggtt cgcttcccgg acaggaggca agagcatttt atcaagggcc tgccagaata
241 ccacgtggtg ggtccagtcc gagtagatgc cagtgggcat tttttgtcat atggcttgca
301 ctatcccatc acgagcagca ggaggaagag agatttggat ggctcagagg actgggtgta
361 ctacagaatt tctcacgagg agaaggacct gttttttaac ttgacggtca atcaaggatt
421 tctttccaat agctacatca tggagaagag atatgggaac ctctcccatg ttaagatgat
481 ggcttcctct gcccccctct gccatctcag tggcacggtt ctacagcagg gcaccagagt
541 tgggacggca gccctcagtg cctgccatgg actgactgga tttttccaac taccacatgg
601 agactttttc attgaacccg tgaagaagca tccactggtt gagggagggt accacccgca
661 catcgtttac aggaggcaga aagttccaga aaccaaggag ccaacctgtg gattaaagga
721 cagtgttaac atctcccaga agcaagagct atggcgggag aagtgggaga ggcacaactt
781 gccaagcaga agcctctctc ggcgttccat cagcaaggag agatgggtgg agacactggt
841 ggtggccgac acaaagatga ttgaatacca tgggagtgag aatgtggagt cctacatcct
901 caccatcatg aacatggtca ctgggttgtt ccataaccca agcattggca atgcaattca
961 cattgttgtg gttcggctca ttctactcga agaagaagag caaggactga aaatagttca
1021 ccatgcagaa aagacactgt ctagcttctg caagtggcag aagagtatca atcccaagag
1081 tgacctcaat cctgttcatc acgacgtggc tgtccttctc accagaaagg acatctgtgc
1141 tggtttcaat cgcccctgcg agaccctggg cctgtctcac ctttcaggaa tgtgtcagcc
1201 tcaccgcagt tgtaacatca atgaagattc gggactccct ctggctttca caattgccca
1261 tgagctagga cacagcttcg gcatccagca tgatgggaaa gaaaatgact gtgagcctgt
1321 gggcagacat ccgtacatca tgtcccgcca gctccagtac gatcccactc cgctgacatg
1381 gtccaagtgc agcgaggagt acatcacccg cttcttggac cgaggctggg ggttctgtct
1441 tgatgacata cctaaaaaga aaggcttgaa gtccaaggtc attgcccccg gagtgatcta
1501 tgatgttcac caccagtgcc agctacaata tggacccaat gctaccttct gccaggaagt
1561 agaaaacgtc tgccagacac tgtggtgctc cgtgaagggc ttttgtcgct ctaagctgga
1621 cgctgctgca gatggaactc aatgtggtga gaagaagtgg tgtatggcag gcaagtgcat
1681 cacagtgggg aagaaaccag agagcattcc tggaggctgg ggccgctggt caccctggtc
1741 ccactgttcc aggacctgtg gggctggagt ccagagcgca gagaggctct gcaacaaccc
1801 cgagccaaag tttggaggga aatattgcac tggagaaaga aaacgctatc gcttgtgcaa
1861 cgtccacccc tgtcgctcag aggcaccaac atttcggcag atgcagtgca gtgaatttga
1921 cactgttccc tacaagaatg aactctacca ctggtttccc atttttaacc caggttatgt
1981 tgacattggg ctcattccaa aaggagcaag ggacataaga gtgatggaaa ttgagggagc
2041 tggaaacttc ctggccatca ggagtgaaga tcctgaaaaa tattacctga atggagggtt
2101 tattatccag tggaacggga actataagct ggcagggact gtctttcagt atgacaggaa
2161 aggagacctg gaaaagctga tggccacagg tcccaccaat gagtctgtgt ggatccagct
2221 tctattccag gtgactaacc ctggcatcaa gtatgagtac acaatccaga aagatggcct
2281 tgacaatgat gttgagcagc agatgtactt ctggcagtac ggccactgga cagagtgcag
2341 tgtgacctgc gggacaggta tccgccgcca aactgcccat tgcataaaga agggccgcgg
2401 gatggtgaaa gctacattct gtgacccaga aacacagccc aatgggagac agaagaagtg
2461 ccatgaaaag gcttgtccac ccaggtggtg ggcaggggag tgggaagcat gctcggcgac
2521 atgcgggccc cacggggaga agaagcgaac cgtgctgtgc atccagacca tggtctctga
2581 cgagcaggct ctcccgccca cagactgcca gcacctgctg aagcccaaga ccctcctttc
2641 ctgcaacaga gacatcctgt gcccctcgga ctggacagtg ggcaactgga gtgagtgttc
2701 tgtttcctgt ggtggtggag tgcggattcg cagtgtcaca tgtgccaaga accatgatga
2761 accttgcgat gtgacaagga aacccaacag ccgagctctg tgtggcctcc agcaatgccc
2821 ttctagccgg agagttctga aaccaaacaa aggcactatt tccaatggaa aaaacccacc
2881 aacactaaag cccgtccctc cacctacatc caggcccaga atgctgacca cacccacagg
2941 gcctgagtct atgagcacaa gcactccagc aatcagcagc cctagtccta ccacagcctc
3001 caaagaagga gacctgggtg ggaaacagtg gcaagatagc tcaacccaac ctgagctgag
3061 ctctcgctat ctcatttcca ctggaagcac ttcccagccc atcctcactt cccaatcctt
3121 gagcattcag ccaagtgagg aaaatgtttc cagttcagat actggtccta cctcggaggg
3181 aggccttgta gctacaacaa caagtggttc tggcttgtca tcttcccgca accctatcac
3241 ttggcctgtg actccatttt acaatacctt gaccaaaggt ccagaaatgg agattcacag
3301 tggctcaggg gaagaaagag aacagcctga ggacaaagat gaaagcaatc ctgtaatatg
3361 gaccaagatc agagtacctg gaaatgacgc tccagtggaa agtacagaaa tgccacttgc
3421 acctccacta acaccagatc tcagcaggga gtcctggtgg ccacccttca gcacagtaat
3481 ggaaggactg ctccccagcc aaaggcccac tacttccgaa actgggacac ccagagttga
3541 ggggatggtt actgaaaagc cagccaacac tctgctccct ctgggaggag accaccagcc
3601 agaaccctca ggaaagacgg caaaccgtaa ccacctgaaa cttccaaaca acatgaacca
3661 aacaaaaagt tctgaaccag tcctgactga ggaggatgca acaagtctga ttactgaggg
3721 ctttttgcta aatgcctcca attacaagca gctcacaaac ggccacggct ctgcacactg
3781 gatcgtcgga aactggagcg agtgctccac cacatgtggc ctgggggcct actggagaag
3841 ggtggagtgc agcacccaga tggattctga ctgtgcggcc atccagagac ctgaccctgc
3901 aaaaagatgc cacctccgtc cctgtgctgg ctggaaagtg ggaaactgga gcaagtgctc
3961 cagaaactgc agtgggggct tcaagatacg cgagattcag tgcgtggaca gccgggacca
4021 ccggaacctg aggccatttc actgccagtt cctggccggc attcctcccc cattgagcat
4081 gagctgtaac ccggagccct gtgaggcgtg gcaggtggag ccttggagcc agtgctccag
4141 gtcctgtgga ggtggagttc aggagagagg agtgttctgt ccaggaggcc tctgtgattg
4201 gacaaaaaga cccacatcca ccatgtcttg caatgagcac ctgtgctgtc actgggccac
4261 tgggaactgg gacctgtgtt ccacttcctg tggaggtggc tttcagaaga ggactgtcca
4321 atgtgtgccc tcagagggca ataaaactga agaccaagac caatgtctat gtgatcacaa
4381 acccagacct ccagaattca aaaaatgcaa ccagcaggcc tgcaagaaaa gtgccgattt
4441 actttgcact aaggacaaac tgtcagccag tttctgccag acactgaaag ccatgaagaa
4501 atgttctgtg cccaccgtga gggctgagtg ctgcttctcg tgtccccaga cacacatcac
4561 acgcacccaa aggcaaagaa ggcaacggtt gctccaaaag tcaaaagaac tctaagccca
4621 aa
//