LOCUS BC130424 4778 bp mRNA linear HUM 04-JAN-2007
DEFINITION Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member
1, mRNA (cDNA clone MGC:163296 IMAGE:40146455), complete cds.
ACCESSION BC130424
VERSION BC130424.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4778)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4778)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (04-JAN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 8 Row: G Column: 7.
FEATURES Location/Qualifiers
source 1..4778
/db_xref="H-InvDB:HIT000390214"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:163296 IMAGE:40146455"
/tissue_type="Cerebellum, Lung, PCR rescued clones"
/clone_lib="NIH_MGC_348"
/lab_host="DH10B"
/note="Vector: pCR-XL-TOPO with reversed insert; Clone
identification sequence tag: TAAGACTT"
gene 1..4778
/gene="ABCB1"
/gene_synonym="ABC20"
/gene_synonym="CD243"
/gene_synonym="GP170"
/gene_synonym="P-gp"
/db_xref="GeneID:5243"
/db_xref="HGNC:HGNC:40"
/db_xref="MIM:171050"
CDS 326..4168
/gene="ABCB1"
/gene_synonym="ABC20"
/gene_synonym="CD243"
/gene_synonym="GP170"
/gene_synonym="P-gp"
/codon_start=1
/product="ATP-binding cassette, sub-family B (MDR/TAP),
member 1"
/protein_id="AAI30425.1"
/db_xref="GeneID:5243"
/db_xref="HGNC:HGNC:40"
/db_xref="MIM:171050"
/translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSN
WLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTG
FFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEI
GWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI
LAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
YNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV
FFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL
EFRNVHFNYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM
VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN
AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE
AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFK
LVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKL
STKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFT
RIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLR
QDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQ
LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQ
KFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE
DVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNT
LEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYD
PLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIV
RAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS
ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA
QKGIYFSMVSVQAGTKRQ"
BASE COUNT 1400 a 915 c 1148 g 1315 t
ORIGIN
1 tgcaacggaa gccagaacat tcctcctgga aattcaacct gtttcgcagt ttctcgagga
61 atcagcattc agtcaatccg ggccgggagc agtcatctgt ggtgaggctg attggctggg
121 caggaacagc gccggggcgt gggctgagca cagccgcttc gctctctttg ccacaggaag
181 cctgagctca ttcgagtagc ggctcttcca agctcaaaga agcagaggcc gctgttcgtt
241 tcctttaggt ctttccacta aagtcggagt atcttcttcc aaaatttcac gtcttggtgg
301 ccgttccaag gagcgcgagg tcgggatgga tcttgaaggg gaccgcaatg gaggagcaaa
361 gaagaagaac ttttttaaac tgaacaataa aagtgaaaaa gataagaagg aaaagaaacc
421 aactgtcagt gtattttcaa tgtttcgcta ttcaaattgg cttgacaagt tgtatatggt
481 ggtgggaact ttggctgcca tcatccatgg ggctggactt cctctcatga tgctggtgtt
541 tggagaaatg acagatatct ttgcaaatgc aggaaattta gaagatctga tgtcaaacat
601 cactaataga agtgatatca atgatacagg gttcttcatg aatctggagg aagacatgac
661 caggtatgcc tattattaca gtggaattgg tgctggggtg ctggttgctg cttacattca
721 ggtttcattt tggtgcctgg cagctggaag acaaatacac aaaattagaa aacagttttt
781 tcatgctata atgcgacagg agataggctg gtttgatgtg cacgatgttg gggagcttaa
841 cacccgactt acagatgatg tctccaagat taatgaagga attggtgaca aaattggaat
901 gttctttcag tcaatggcaa catttttcac tgggtttata gtaggattta cacgtggttg
961 gaagctaacc cttgtgattt tggccatcag tcctgttctt ggactgtcag ctgctgtctg
1021 ggcaaagata ctatcttcat ttactgataa agaactctta gcgtatgcaa aagctggagc
1081 agtagctgaa gaggtcttgg cagcaattag aactgtgatt gcatttggag gacaaaagaa
1141 agaacttgaa aggtacaaca aaaatttaga agaagctaaa agaattggga taaagaaagc
1201 tattacagcc aatatttcta taggtgctgc tttcctgctg atctatgcat cttatgctct
1261 ggccttctgg tatgggacca ccttggtcct ctcaggggaa tattctattg gacaagtact
1321 cactgtattc ttttctgtat taattggggc ttttagtgtt ggacaggcat ctccaagcat
1381 tgaagcattt gcaaatgcaa gaggagcagc ttatgaaatc ttcaagataa ttgataataa
1441 gccaagtatt gacagctatt cgaagagtgg gcacaaacca gataatatta agggaaattt
1501 ggaattcaga aatgttcact tcaattaccc atctcgaaaa gaagttaaga tcttgaaggg
1561 cctgaacctg aaggtgcaga gtgggcagac ggtggccctg gttggaaaca gtggctgtgg
1621 gaagagcaca acagtccagc tgatgcagag gctctatgac cccacagagg ggatggtcag
1681 tgttgatgga caggatatta ggaccataaa tgtaaggttt ctacgggaaa tcattggtgt
1741 ggtgagtcag gaacctgtat tgtttgccac cacgatagct gaaaacattc gctatggccg
1801 tgaaaatgtc accatggatg agattgagaa agctgtcaag gaagccaatg cctatgactt
1861 tatcatgaaa ctgcctcata aatttgacac cctggttgga gagagagggg cccagttgag
1921 tggtgggcag aagcagagga tcgccattgc acgtgccctg gttcgcaacc ccaagatcct
1981 cctgctggat gaggccacgt cagccttgga cacagaaagc gaagcagtgg ttcaggtggc
2041 tctggataag gccagaaaag gtcggaccac cattgtgata gctcatcgtt tgtctacagt
2101 tcgtaatgct gacgtcatcg ctggtttcga tgatggagtc attgtggaga aaggaaatca
2161 tgatgaactc atgaaagaga aaggcattta cttcaaactt gtcacaatgc agacagcagg
2221 aaatgaagtt gaattagaaa atgcagctga tgaatccaaa agtgaaattg atgccttgga
2281 aatgtcttca aatgattcaa gatccagtct aataagaaaa agatcaactc gtaggagtgt
2341 ccgtggatca caagcccaag acagaaagct tagtaccaaa gaggctctgg atgaaagtat
2401 acctccagtt tccttttgga ggattatgaa gctaaattta actgaatggc cttattttgt
2461 tgttggtgta ttttgtgcca ttataaatgg aggcctgcaa ccagcatttg caataatatt
2521 ttcaaagatt ataggggttt ttacaagaat tgatgatcct gaaacaaaac gacagaatag
2581 taacttgttt tcactattgt ttctagccct tggaattatt tcttttatta catttttcct
2641 tcagggtttc acatttggca aagctggaga gatcctcacc aagcggctcc gatacatggt
2701 tttccgatcc atgctcagac aggatgtgag ttggtttgat gaccctaaaa acaccactgg
2761 agcattgact accaggctcg ccaatgatgc tgctcaagtt aaaggggcta taggttccag
2821 gcttgctgta attacccaga atatagcaaa tcttgggaca ggaataatta tatccttcat
2881 ctatggttgg caactaacac tgttactctt agcaattgta cccatcattg caatagcagg
2941 agttgttgaa atgaaaatgt tgtctggaca agcactgaaa gataagaaag aactagaagg
3001 tgctgggaag atcgctactg aagcaataga aaacttccga accgttgttt ctttgactca
3061 ggagcagaag tttgaacata tgtatgctca gagtttgcag gtaccataca gaaactcttt
3121 gaggaaagca cacatctttg gaattacatt ttccttcacc caggcaatga tgtatttttc
3181 ctatgctgga tgtttccggt ttggagccta cttggtggca cataaactca tgagctttga
3241 ggatgttctg ttagtatttt cagctgttgt ctttggtgcc atggccgtgg ggcaagtcag
3301 ttcatttgct cctgactatg ccaaagccaa aatatcagca gcccacatca tcatgatcat
3361 tgaaaaaacc cctttgattg acagctacag cacggaaggc ctaatgccga acacattgga
3421 aggaaatgtc acatttggtg aagttgtatt caactatccc acccgaccgg acatcccagt
3481 gcttcaggga ctgagcctgg aggtgaagaa gggccagacg ctggctctgg tgggcagcag
3541 tggctgtggg aagagcacag tggtccagct cctggagcgg ttctacgacc ccttggcagg
3601 gaaagtgctg cttgatggca aagaaataaa gcgactgaat gttcagtggc tccgagcaca
3661 cctgggcatc gtgtcccagg agcccatcct gtttgactgc agcattgctg agaacattgc
3721 ctatggagac aacagccggg tggtgtcaca ggaagagatc gtgagggcag caaaggaggc
3781 caacatacat gccttcatcg agtcactgcc taataaatat agcactaaag taggagacaa
3841 aggaactcag ctctctggtg gccagaaaca acgcattgcc atagctcgtg cccttgttag
3901 acagcctcat attttgcttt tggatgaagc cacgtcagct ctggatacag aaagtgaaaa
3961 ggttgtccaa gaagccctgg acaaagccag agaaggccgc acctgcattg tgattgctca
4021 ccgcctgtcc accatccaga atgcagactt aatagtggtg tttcagaatg gcagagtcaa
4081 ggagcatggc acgcatcagc agctgctggc acagaaaggc atctattttt caatggtcag
4141 tgtccaggct ggaacaaagc gccagtgaac tctgactgta tgagatgtta aatacttttt
4201 aatatttgtt tagatatgac atttattcaa agttaaaagc aaacacttac agaattatga
4261 agaggtatct gtttaacatt tcctcagtca agttcagagt cttcagagac ttcgtaatta
4321 aaggaacaga gtgagagaca tcatcaagtg gagagaaatc atagtttaaa ctgcattata
4381 aattttataa cagaattaaa gtagatttta aaagataaaa tgtgtaattt tgtttatatt
4441 ttcccatttg gactgtaact gactgccttg ctaaaagatt atagaagtag caaaaagtat
4501 tgaaatgttt gcataaagtg tctataataa aactaaactt tcatgtgact ggagtcatct
4561 tgtccaaact gcctgtgaat atatcttctc tcaattggaa tattgtagat aacttctgct
4621 ttaaaaaagt tttctttaaa tatacctact catttttgtg ggaatggtta agcagtttaa
4681 ataattcctg ttgtatatgt ctattcacat tgggtcttac agaaccatct ggcttcattc
4741 ttcttggact tgatcctgct gattcttgca tttccaca
//