LOCUS BC130287 4747 bp mRNA linear HUM 04-JAN-2007
DEFINITION Homo sapiens ADAM metallopeptidase with thrombospondin type 1
motif, 3, mRNA (cDNA clone MGC:163159 IMAGE:40146318), complete
cds.
ACCESSION BC130287
VERSION BC130287.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4747)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4747)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (04-JAN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 8 Row: A Column: 14.
FEATURES Location/Qualifiers
source 1..4747
/db_xref="H-InvDB:HIT000390077"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:163159 IMAGE:40146318"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_364"
/lab_host="DH10B"
/note="Vector: pCR-XL-TOPO with reversed insert; Clone
identification sequence tag: AGATGTGG"
gene 1..4747
/gene="ADAMTS3"
/gene_synonym="ADAMTS-4"
/db_xref="GeneID:9508"
/db_xref="HGNC:HGNC:219"
/db_xref="MIM:605011"
CDS 35..3652
/gene="ADAMTS3"
/gene_synonym="ADAMTS-4"
/codon_start=1
/product="ADAM metallopeptidase with thrombospondin type 1
motif, 3"
/protein_id="AAI30288.1"
/db_xref="GeneID:9508"
/db_xref="HGNC:HGNC:219"
/db_xref="MIM:605011"
/translation="MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYEL
VTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLV
APGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTSV
AISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFH
YRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEH
VQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCR
WASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSS
AFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYI
HSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCS
HPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRT
CGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHF
EYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRG
ECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARH
VLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTD
GPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQ
CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEW
EHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKT
GPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQM
EVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTS
LVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVT
VPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLE
R"
BASE COUNT 1405 a 968 c 1100 g 1274 t
ORIGIN
1 ttgcccagta gttggaaagt gaactcgact cgtgatggtt ctcctgtcac tttggttgat
61 agcagccgct ctggtagagg ttaggacttc agctgatgga caagctggta atgaagaaat
121 ggtgcaaata gatttaccaa taaagagata tagagagtat gagctggtga ctccagtcag
181 cacaaatcta gaaggacgct atctctccca tactctttct gcgagtcaca aaaagaggtc
241 agcgagggac gtgtcttcca accctgagca gttgttcttt aacatcacgg catttggaaa
301 agattttcat ctgcgactaa agcccaacac tcaactagta gctcctgggg ctgttgtgga
361 gtggcatgag acatctctgg tgcctgggaa tataaccgat cccattaaca accatcaacc
421 aggaagtgct acgtatagaa tccggaaaac agagcctttg cagactaact gtgcttatgt
481 tggtgacatc gtggacattc caggaacctc tgttgccatc agcaactgtg atggtctggc
541 tggaatgata aaaagtgata atgaagagta tttcattgaa cccttggaaa gaggtaaaca
601 gatggaggaa gaaaaaggaa ggattcatgt tgtctacaag agatcagctg tagaacaggc
661 tcccatagac atgtccaaag acttccacta cagagagtcg gacctggaag gccttgatga
721 tctaggtact gtttatggca acatccacca gcagctgaat gaaacaatga gacgccgcag
781 acacgcggga gaaaacgatt acaatatcga ggtactgctg ggagtggatg actctgtggt
841 ccgtttccat ggcaaagagc acgtccaaaa ctacctcctg accctaatga acattgtgaa
901 tgaaatttac catgatgagt ccctcggagt gcatataaat gtggtcctgg tgcgcatgat
961 aatgctggga tatgcaaagt ccatcagcct catagaaagg ggaaacccat ccagaagctt
1021 ggagaatgtg tgtcgctggg cgtcccaaca gcaaagatct gatctcaacc actctgaaca
1081 ccatgaccat gcaatttttt taaccaggca agactttgga cctgctggaa tgcaaggata
1141 tgctccagtc accggcatgt gtcatccagt gagaagttgt accctgaatc atgaggatgg
1201 tttttcatct gcttttgtag tagcccatga aacgggccat gtgttgggaa tggagcatga
1261 tggacaaggc aacaggtgtg gtgatgagac tgctatggga agtgtcatgg ctcccttggt
1321 acaagcagca ttccatcgtt accactggtc ccgatgcagt ggtcaagaac tgaaaagata
1381 tatccattcc tatgactgtc tccttgatga cccttttgat catgattggc ctaaactccc
1441 agaacttcct ggaatcaatt attctatgga tgagcaatgt cgttttgatt ttggtgttgg
1501 ctataaaatg tgcaccgcgt tccgaacctt tgacccatgt aaacagctgt ggtgtagcca
1561 tcctgataat ccctactttt gtaagactaa aaagggacct ccacttgatg ggactgaatg
1621 tgctgctgga aaatggtgct ataagggtca ttgcatgtgg aagaatgcta atcagcaaaa
1681 acaagatggc aattgggggt catggactaa atttggctcc tgttctcgga catgtggaac
1741 tggtgttcgt ttcagaacac gccagtgcaa taatcccatg cccatcaatg gtggtcagga
1801 ttgtcctggt gttaattttg agtaccagct ttgtaacaca gaagaatgcc aaaaacactt
1861 tgaggacttc agagcacagc agtgtcagca gcgaaactcc cactttgaat accagaatac
1921 caaacaccac tggttgccat atgaacatcc tgaccccaag aaaagatgcc acctttactg
1981 tcagtccaag gagactggag atgttgctta catgaaacaa ctggtgcatg atggaacgca
2041 ctgttcttac aaagatccat atagcatatg tgtgcgagga gagtgtgtga aagtgggctg
2101 tgataaagaa attggttcta ataaggttga ggataagtgt ggtgtctgtg gaggagataa
2161 ttcccactgc cgaaccgtga aggggacatt taccagaact cccaggaagc ttgggtacct
2221 taagatgttt gatatacccc ctggggctag acatgtgtta atccaagaag acgaggcttc
2281 tcctcatatt cttgctatta agaaccaggc tacaggccat tatattttaa atggcaaagg
2341 ggaggaagcc aagtcgcgga ccttcataga tcttggtgtg gagtgggatt ataacattga
2401 agatgacatt gaaagtcttc acaccgatgg acctttacat gatcctgtta ttgttttgat
2461 tatacctcaa gaaaatgata cccgctctag cctgacatat aagtacatca tccatgaaga
2521 ctctgtacct acaatcaaca gcaacaatgt catccaggaa gaattagata cttttgagtg
2581 ggctttgaag agctggtctc agtgttccaa accctgtggt ggaggtttcc agtacactaa
2641 atatggatgc cgtaggaaaa gtgataataa aatggtccat cgcagcttct gtgaggccaa
2701 caaaaagccg aaacctatta gacgaatgtg caatattcaa gagtgtacac atccactctg
2761 ggtagcagaa gaatgggaac actgcaccaa aacctgtgga agttctggct atcagcttcg
2821 cactgtacgc tgccttcagc cactccttga tggcaccaac cgctctgtgc acagcaaata
2881 ctgcatgggt gaccgtcccg agagccgccg gccctgtaac agagtgccct gccctgcaca
2941 gtggaaaaca ggaccctgga gtgagtgttc agtgacctgc ggtgaaggaa cggaggtgag
3001 gcaggtcctc tgcagggctg gggaccactg tgatggtgaa aagcctgagt cggtcagagc
3061 ctgtcaactg cctccttgta atgatgaacc atgtttggga gacaagtcca tattctgtca
3121 aatggaagtg ttggcacgat actgctccat accaggttat aacaagttat gttgtgagtc
3181 ctgcagcaag cgcagtagca ccctgccacc accatacctt ctagaagctg ctgaaactca
3241 tgatgatgtc atctctaacc ctagtgacct ccctagatct ctagtgatgc ctacatcttt
3301 ggttccttat cattcagaga cccctgcaaa gaagatgtct ttgagtagca tctcttcagt
3361 gggaggtcca aatgcatatg ctgctttcag gccaaacagt aaacctgatg gtgctaattt
3421 acgccagagg agtgctcagc aagcaggaag taagactgtg agactggtca ccgtaccatc
3481 ctccccaccc accaagaggg tccacctcag ttcagcttca caaatggctg ctgcttcctt
3541 ctttgcagcc agtgattcaa taggtgcttc ttctcaggca agaacctcaa agaaagatgg
3601 aaagatcatt gacaacagac gtccgacaag atcatccacc ttagaaagat gagaaagtga
3661 accaaaaagg ctagaaacca gaggaaaacc tggacaacct ctctcttccc atggtgcata
3721 tgcttgttta aagtggaaat ctctatagat cgtcagctca ttttatctgt aattggaaga
3781 acagaaagtg ctggctcact ttctagttgc tttcatcctc cttttgttct gcattgactc
3841 atttaccaga attcattgga agaaatcacc aaagattatt acaaaagaaa aatatgttgc
3901 taagattgtg ttggtcgctc tctgaagcag aaaagggact ggaaccaatt gtgcatatca
3961 gctgactttt tgtttgtttt agaaaagtta cagtaaaaat taaaaagaga taccaatggt
4021 ttacacttta acaagaaatt ttggatatgg aacaaagaat tcttagactt gtattcctat
4081 ttatctatat tagaaatatt gtatgagcaa atttgcagct gttgtgtaaa tactgtatat
4141 tgcaaaaatc agtattattt taagagatgt gttctcaaat gattgtttac tatattacat
4201 ttctggatgt tctaggtgcc tgtcgttgag tattgccttg tttgacattc tataggttaa
4261 ttttcaaagc agagtattac aaaagagaag ttagaattac agctactgac aatataaagg
4321 gttttgttga atcaacaatg tgatacgtaa attatagaaa aagaaaagaa acacaaaagc
4381 tatagatata cagatatcag cttacctatt gccttctata cttataattt aaaggattgg
4441 tgtcttagta cacttgtggt cacagggatc aacgaatagt aaataatgaa ctcgtgcaag
4501 acaaaactga aaccctcttt ccaggacctc agtaggcacc gttgaggtgt cctttgtttt
4561 tgtgtgtgtg tgttcttttt taattttcgc attgttgaca gatacaaaca gttatactca
4621 atgtactgta ataatcgcaa aggaaaaagt tttgggataa cttatttgta tgttggtagc
4681 tgagaaaaat atcatcagtc tagaattgat atttgagtat agtagagctt tggggctttg
4741 aaggcag
//