LOCUS BC126350 3307 bp mRNA linear HUM 12-JAN-2007
DEFINITION Homo sapiens fms-related tyrosine kinase 3, mRNA (cDNA clone
MGC:161628 IMAGE:8992066), complete cds.
ACCESSION BC126350
VERSION BC126350.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3307)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3307)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 7 Row: K Column: 8.
FEATURES Location/Qualifiers
source 1..3307
/db_xref="H-InvDB:HIT000388942"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:161628 IMAGE:8992066"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_362"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: CCAAACTA"
gene 1..3307
/gene="FLT3"
/gene_synonym="CD135"
/gene_synonym="FLK2"
/gene_synonym="STK1"
/db_xref="GeneID:2322"
/db_xref="HGNC:HGNC:3765"
/db_xref="MIM:136351"
CDS 67..3048
/gene="FLT3"
/gene_synonym="CD135"
/gene_synonym="FLK2"
/gene_synonym="STK1"
/codon_start=1
/product="fms-related tyrosine kinase 3"
/protein_id="AAI26351.1"
/db_xref="GeneID:2322"
/db_xref="HGNC:HGNC:3765"
/db_xref="MIM:136351"
/translation="MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNND
SSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNIS
CLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSI
RNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEE
KVLHELFGMDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVH
VNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSK
HPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPC
EQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQA
SCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIK
GFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKY
KKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKV
MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT
LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGS
REVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKG
MEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMA
PESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYA
TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNR
RPFSREMDLGLLSPQAQVEDS"
BASE COUNT 983 a 691 c 754 g 879 t
ORIGIN
1 gttttacacg aggcggcatc gcagggctgg gccggcgcgg cctggggacc ccgggctccg
61 gaggccatgc cggcgttggc gcgcgacggc ggccagctgc cgctgctcgt tgttttttct
121 gcaatgatat ttgggactat tacaaatcaa gatctgcctg tgatcaagtg tgttttaatc
181 aatcataaga acaatgattc atcagtgggg aagtcatcat catatcccat ggtatcagaa
241 tccccggaag acctcgggtg tgcgttgaga ccccagagct cagggacagt gtacgaagct
301 gccgctgtgg aagtggatgt atctgcttcc atcacactgc aagtgctggt cgatgcccca
361 gggaacattt cctgtctctg ggtctttaag cacagctccc tgaattgcca gccacatttt
421 gatttacaaa acagaggagt tgtttccatg gtcattttga aaatgacaga aacccaagct
481 ggagaatacc tactttttat tcagagtgaa gctaccaatt acacaatatt gtttacagtg
541 agtataagaa ataccctgct ttacacatta agaagacctt actttagaaa aatggaaaac
601 caggacgccc tggtctgcat atctgagagc gttccagagc cgatcgtgga atgggtgctt
661 tgcgattcac agggggaaag ctgtaaagaa gaaagtccag ctgttgttaa aaaggaggaa
721 aaagtgcttc atgaattatt tgggatggac ataaggtgct gtgccagaaa tgaactgggc
781 agggaatgca ccaggctgtt cacaatagat ctaaatcaaa ctcctcagac cacattgcca
841 caattatttc ttaaagtagg ggaaccctta tggataaggt gcaaagctgt tcatgtgaac
901 catggattcg ggctcacctg ggaattagaa aacaaagcac tcgaggaggg caactacttt
961 gagatgagta cctattcaac aaacagaact atgatacgga ttctgtttgc ttttgtatca
1021 tcagtggcaa gaaacgacac cggatactac acttgttcct cttcaaagca tcccagtcaa
1081 tcagctttgg ttaccatcgt agaaaaggga tttataaatg ctaccaattc aagtgaagat
1141 tatgaaattg accaatatga agagttttgt ttttctgtca ggtttaaagc ctacccacaa
1201 atcagatgta cgtggacctt ctctcgaaaa tcatttcctt gtgagcaaaa gggtcttgat
1261 aacggataca gcatatccaa gttttgcaat cataagcacc agccaggaga atatatattc
1321 catgcagaaa atgatgatgc ccaatttacc aaaatgttca cgctgaatat aagaaggaaa
1381 cctcaagtgc tcgcagaagc atcggcaagt caggcgtcct gtttctcgga tggataccca
1441 ttaccatctt ggacctggaa gaagtgttca gacaagtctc ccaactgcac agaagagatc
1501 acagaaggag tctggaatag aaaggctaac agaaaagtgt ttggacagtg ggtgtcgagc
1561 agtactctaa acatgagtga agccataaaa gggttcctgg tcaagtgctg tgcatacaat
1621 tcccttggca catcttgtga gacgatcctt ttaaactctc caggcccctt ccctttcatc
1681 caagacaaca tctcattcta tgcaacaatt ggtgtttgtc tcctcttcat tgtcgtttta
1741 accctgctaa tttgtcacaa gtacaaaaag caatttaggt atgaaagcca gctacagatg
1801 gtacaggtga ccggctcctc agataatgag tacttctacg ttgatttcag agaatatgaa
1861 tatgatctca aatgggagtt tccaagagaa aatttagagt ttgggaaggt actaggatca
1921 ggtgcttttg gaaaagtgat gaacgcaaca gcttatggaa ttagcaaaac aggagtctca
1981 atccaggttg ccgtcaaaat gctgaaagaa aaagcagaca gctctgaaag agaggcactc
2041 atgtcagaac tcaagatgat gacccagctg ggaagccacg agaatattgt gaacctgctg
2101 ggggcgtgca cactgtcagg accaatttac ttgatttttg aatactgttg ctatggtgat
2161 cttctcaact atctaagaag taaaagagaa aaatttcaca ggacttggac agagattttc
2221 aaggaacaca atttcagttt ttaccccact ttccaatcac atccaaattc cagcatgcct
2281 ggttcaagag aagttcagat acacccggac tcggatcaaa tctcagggct tcatgggaat
2341 tcatttcact ctgaagatga aattgaatat gaaaaccaaa aaaggctgga agaagaggag
2401 gacttgaatg tgcttacatt tgaagatctt ctttgctttg catatcaagt tgccaaagga
2461 atggaatttc tggaatttaa gtcgtgtgtt cacagagacc tggccgccag gaacgtgctt
2521 gtcacccacg ggaaagtggt gaagatatgt gactttggat tggctcgaga tatcatgagt
2581 gattccaact atgttgtcag gggcaatgcc cgtctgcctg taaaatggat ggcccccgaa
2641 agcctgtttg aaggcatcta caccattaag agtgatgtct ggtcatatgg aatattactg
2701 tgggaaatct tctcacttgg tgtgaatcct taccctggca ttccggttga tgctaacttc
2761 tacaaactga ttcaaaatgg atttaaaatg gatcagccat tttatgctac agaagaaata
2821 tacattataa tgcaatcctg ctgggctttt gactcaagga aacggccatc cttccctaat
2881 ttgacttcgt ttttaggatg tcagctggca gatgcagaag aagcgatgta tcagaatgtg
2941 gatggccgtg tttcggaatg tcctcacacc taccaaaaca ggcgaccttt cagcagagag
3001 atggatttgg ggctactctc tccgcaggct caggtcgaag attcgtagag gaacaattta
3061 gttttaagga cttcatccct ccacctatcc ctaacaggct gtagattacc aaaacaagat
3121 taatttcatc actaaaagaa aatctattat caactgctgc ttcaccagac ttttctctag
3181 aagctgtctg cgtttactct tgttttcaaa gggacttttg taaaatcaaa tcatcctgtc
3241 acaaggcagg aggagctgat aatgaacttt attggagcat tgatctgcat ccaaggcctt
3301 ctcaggc
//