LOCUS BC121045 2248 bp mRNA linear HUM 04-OCT-2006
DEFINITION Homo sapiens ADAM metallopeptidase domain 18, mRNA (cDNA clone
MGC:149740 IMAGE:40117918), complete cds.
ACCESSION BC121045
VERSION BC121045.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2248)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2248)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-AUG-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 27 Row: k Column: 11.
FEATURES Location/Qualifiers
source 1..2248
/db_xref="H-InvDB:HIT000388242"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:149740 IMAGE:40117918"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_282"
/note="Vector: pCR-Blunt II-TOPO; Clone identification
sequence tag: TGCTCC sequenced from the reverse primer"
gene 1..2248
/gene="ADAM18"
/gene_synonym="ADAM27"
/gene_synonym="tMDCIII"
/db_xref="GeneID:8749"
/db_xref="HGNC:HGNC:196"
CDS 1..2220
/gene="ADAM18"
/gene_synonym="ADAM27"
/gene_synonym="tMDCIII"
/codon_start=1
/product="ADAM metallopeptidase domain 18"
/protein_id="AAI21046.1"
/db_xref="GeneID:8749"
/db_xref="HGNC:HGNC:196"
/translation="MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERK
MIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFP
NSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHI
WQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLV
NTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLV
YRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ
CFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPV
CGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPC
RKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGK
GAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQ
STVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNC
NATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDGNFQKSGDFYTEKGYN
THWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRENAEYNRNSSVVSESDDVGH"
BASE COUNT 721 a 394 c 446 g 687 t
ORIGIN
1 atgttccttc tcctcgccct cctcactgag cttggaagac tgcaagccca cgaaggttct
61 gaaggaatat ttctgcatgt cacagttcca cggaagatta agtcaaatga cagtgaagtt
121 tcagagagga agatgattta catcattaca attgatggac aaccttacac tctacatctc
181 ggaaaacaat cattcttacc ccagaacttt ttggtttata catataatga aactggatct
241 ttgcattctg tgtctccata ttttatgatg cattgccatt accaaggata tgctgccgaa
301 tttccaaatt catttgtgac actcagtata tgttctggtc tcaggggatt tctccagttt
361 gaaaatatca gttatggaat tgaaccagta gaatcttcag caagatttga gcatataatt
421 tatcaaatga aaaataatga tccaaatgta tccattttag cagtaaatta cagtcatatt
481 tggcagaaag accagcccta caaagttcct ttaaactcac agataaaaaa tctttcaaaa
541 ctattacccc aatatctgga aatatacatt atagtggaaa aagctttgta tgattatatg
601 ggatctgaaa tgatggctgt aacacaaaaa attgtccagg ttattgggct tgtcaacact
661 atgtttaccc agttcaaatt gactgttata ctgtcttcct tggaattgtg gtcaaatgaa
721 aaccagattt ccaccagtgg ggatgctgat gatatattac aaagattttt ggcatggaaa
781 cgggactatc tcatcctacg gccccatgac atagcatact tacttgttta caggaaacat
841 cctaaatatg tgggagcaac atttcctggc actgtatgca ataaaagcta tgatgcaggt
901 attgctatgt atccagatgc aataggtttg gagggatttt cggttattat agctcaactg
961 cttggcctta atgtaggatt aacatatgat gacatcactc agtgtttctg tctgagagct
1021 acatgcatca tgaatcatga agcagtgagt gccagtggta gaaagatttt tagcaactgc
1081 agcatgcacg actatagata ttttgtttca aaatttgaga ctaaatgcct tcagaagctt
1141 tcaaatttgc aaccattaca tcaaaatcaa ccagtgtgtg gtaatgggat tttggaatcc
1201 aatgaagaat gtgactgtgg taataaaaat gaatgtcaat ttaagaagtg ctgtgattat
1261 aacacatgta aactgaaggg ctcagtaaaa tgtggttctg gaccatgttg tacatcaaag
1321 tgtgagttgt caatagcagg cactccatgt agaaagagta ttgatccaga gtgtgatttt
1381 acagagtact gcaatggaac ctctagtaat tgtgttcctg acacttatgc attgaatggc
1441 cgtttgtgca agttgggaac tgcctattgc tataacggac aatgtcaaac tactgataac
1501 cagtgtgcca agatatttgg aaaaggtgct caaggtgctc catttgcctg ttttaaagaa
1561 gttaattctc tgcatgaaag atctgaaaac tgtggtttta aaaattcaca accattacct
1621 tgtgaacgga aggatgttct ctgtggaaaa ttagcttgtg ttcagccaca taaaaatgct
1681 aataaaagtg acgctcaatc tacagtttat tcatatattc aagaccatgt atgtgtatct
1741 atagccactg gttcctccat gagatcagat ggaacagaca atgcctatgt ggctgatggc
1801 accatgtgtg gtccagaaat gtactgtgta aataaaacct gcagaaaagt tcatttaatg
1861 ggatataact gtaatgccac cacaaaatgc aaagggaaag ggatatgtaa taattttggt
1921 aattgtcaat gcttccctgg acatagacct ccagattgta aattccagtt tggttcccca
1981 gggggtagta ttgatgatgg aaattttcag aaatctggtg acttttatac tgaaaaaggc
2041 tacaatacac actggaacaa ctggtttatt ctgagtttct gcatttttct gccgtttttc
2101 atagttttca ccactgtgat ctttaaaaga aatgaaataa gtaaatcatg taacagagag
2161 aatgcagagt ataatcgtaa ttcatccgtt gtatcagaaa gcgatgacgt gggacattaa
2221 tattgcacag aacttccata gcaaataa
//