LOCUS BC117422 2582 bp mRNA linear HUM 26-JUN-2006
DEFINITION Homo sapiens toll-like receptor 4, mRNA (cDNA clone MGC:151031
IMAGE:40125973), complete cds.
ACCESSION BC117422
VERSION BC117422.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2582)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2582)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (26-MAY-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 6 Row: M Column: 22.
FEATURES Location/Qualifiers
source 1..2582
/db_xref="H-InvDB:HIT000387712"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:151031 IMAGE:40125973"
/tissue_type="Brain, cerebellum, PCR rescued clones"
/clone_lib="NIH_MGC_310"
/note="Vector: pCR4-TOPO; Clone identification sequence
tag: CTGGGTCC"
gene 1..2582
/gene="TLR4"
/gene_synonym="CD284"
/gene_synonym="hToll"
/gene_synonym="TOLL"
/db_xref="GeneID:7099"
/db_xref="HGNC:HGNC:11850"
/db_xref="MIM:603030"
CDS 21..2540
/gene="TLR4"
/gene_synonym="CD284"
/gene_synonym="hToll"
/gene_synonym="TOLL"
/codon_start=1
/product="toll-like receptor 4"
/protein_id="AAI17423.1"
/db_xref="GeneID:7099"
/db_xref="HGNC:HGNC:11850"
/db_xref="MIM:603030"
/translation="MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELN
FYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLS
HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHN
LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFI
QPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSA
LEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQH
LELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCS
QSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLI
YLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQL
EQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH
FPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLN
ITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSS
QDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQH
FIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWE
DSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI"
BASE COUNT 712 a 564 c 546 g 760 t
ORIGIN
1 gcagtgagga tgatgccagg atgatgtctg cctcgcgcct ggctgggact ctgatcccag
61 ccatggcctt cctctcctgc gtgagaccag aaagctggga gccctgcgtg gaggtggttc
121 ctaatattac ttatcaatgc atggagctga atttctacaa aatccccgac aacctcccct
181 tctcaaccaa gaacctggac ctgagcttta atcccctgag gcatttaggc agctatagct
241 tcttcagttt cccagaactg caggtgctgg atttatccag gtgtgaaatc cagacaattg
301 aagatggggc atatcagagc ctaagccacc tctctacctt aatattgaca ggaaacccca
361 tccagagttt agccctggga gccttttctg gactatcaag tttacagaag ctggtggctg
421 tggagacaaa tctagcatct ctagagaact tccccattgg acatctcaaa actttgaaag
481 aacttaatgt ggctcacaat cttatccaat ctttcaaatt acctgagtat ttttctaatc
541 tgaccaatct agagcacttg gacctttcca gcaacaagat tcaaagtatt tattgcacag
601 acttgcgggt tctacatcaa atgcccctac tcaatctctc tttagacctg tccctgaacc
661 ctatgaactt tatccaacca ggtgcattta aagaaattag gcttcataag ctgactttaa
721 gaaataattt tgatagttta aatgtaatga aaacttgtat tcaaggtctg gctggtttag
781 aagtccatcg tttggttctg ggagaattta gaaatgaagg aaacttggaa aagtttgaca
841 aatctgctct agagggcctg tgcaatttga ccattgaaga attccgatta gcatacttag
901 actactacct cgatgatatt attgacttat ttaattgttt gacaaatgtt tcttcatttt
961 ccctggtgag tgtgactatt gaaagggtaa aagacttttc ttataatttc ggatggcaac
1021 atttagaatt agttaactgt aaatttggac agtttcccac attgaaactc aaatctctca
1081 aaaggcttac tttcacttcc aacaaaggtg ggaatgcttt ttcagaagtt gatctaccaa
1141 gccttgagtt tctagatctc agtagaaatg gcttgagttt caaaggttgc tgttctcaaa
1201 gtgattttgg gacaaccagc ctaaagtatt tagatctgag cttcaatggt gttattacca
1261 tgagttcaaa cttcttgggc ttagaacaac tagaacatct ggatttccag cattccaatt
1321 tgaaacaaat gagtgagttt tcagtattcc tatcactcag aaacctcatt taccttgaca
1381 tttctcatac tcacaccaga gttgctttca atggcatctt caatggcttg tccagtctcg
1441 aagtcttgaa aatggctggc aattctttcc aggaaaactt ccttccagat atcttcacag
1501 agctgagaaa cttgaccttc ctggacctct ctcagtgtca actggagcag ttgtctccaa
1561 cagcatttaa ctcactctcc agtcttcagg tactaaatat gagccacaac aacttctttt
1621 cattggatac gtttccttat aagtgtctga actccctcca ggttcttgat tacagtctca
1681 atcacataat gacttccaaa aaacaggaac tacagcattt tccaagtagt ctagctttct
1741 taaatcttac tcagaatgac tttgcttgta cttgtgaaca ccagagtttc ctgcaatgga
1801 tcaaggacca gaggcagctc ttggtggaag ttgaacgaat ggaatgtgca acaccttcag
1861 ataagcaggg catgcctgtg ctgagtttga atatcacctg tcagatgaat aagaccatca
1921 ttggtgtgtc ggtcctcagt gtgcttgtag tatctgttgt agcagttctg gtctataagt
1981 tctattttca cctgatgctt cttgctggct gcataaagta tggtagaggt gaaaacatct
2041 atgatgcctt tgttatctac tcaagccagg atgaggactg ggtaaggaat gagctagtaa
2101 agaatttaga agaaggggtg cctccatttc agctctgcct tcactacaga gactttattc
2161 ccggtgtggc cattgctgcc aacatcatcc atgaaggttt ccataaaagc cgaaaggtga
2221 ttgttgtggt gtcccagcac ttcatccaga gccgctggtg tatctttgaa tatgagattg
2281 ctcagacctg gcagtttctg agcagtcgtg ctggtatcat cttcattgtc ctgcagaagg
2341 tggagaagac cctgctcagg cagcaggtgg agctgtaccg ccttctcagc aggaacactt
2401 acctggagtg ggaggacagt gtcctggggc ggcacatctt ctggagacga ctcagaaaag
2461 ccctgctgga tggtaaatca tggaatccag aaggaacagt gggtacagga tgcaattggc
2521 aggaagcaac atctatctga agaggaaaaa taaaaacctc ctgaggcatt tcttgcccag
2581 ct
//