LOCUS BC117283 2118 bp mRNA linear HUM 03-NOV-2008
DEFINITION Homo sapiens cancer susceptibility candidate 1, mRNA (cDNA clone
IMAGE:40125834), partial cds.
ACCESSION BC117283
VERSION BC117283.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2118)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2118)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (26-MAY-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 6 Row: H Column: 3.
FEATURES Location/Qualifiers
source 1..2118
/db_xref="H-InvDB:HIT000387573"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:40125834"
/tissue_type="Colon, PCR rescued clones"
/clone_lib="NIH_MGC_295"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: TCTAGCAT"
gene <1..2118
/gene="CASC1"
/gene_synonym="LAS1"
/db_xref="GeneID:55259"
/db_xref="HGNC:HGNC:29599"
CDS <1..2068
/gene="CASC1"
/gene_synonym="LAS1"
/codon_start=2
/product="CASC1 protein"
/protein_id="AAI17284.2"
/db_xref="GeneID:55259"
/db_xref="HGNC:HGNC:29599"
/translation="EEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEEL
YLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEE
VIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILL
KQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATS
DIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQE
RGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENS
SEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPP
ETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKER
LVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCM
LSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVK
AYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQR
LKIKEESEAFSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLST
RLLSYS"
BASE COUNT 739 a 351 c 458 g 570 t
ORIGIN
1 ggaagaggaa gcccgtttga aatatgagaa agaagaaatg gaaaggcttg aaatacagcg
61 aattgagaaa gaaaaatggc atcgacttga agcaaaagat ctagaaagga gaaatgaaga
121 acttgaagaa ctttatttat tagagaggtg ttttcctgaa gcagagaaat tgaaacagga
181 aactaaattg ctttctcagt ggaagcacta cattcaatgt gatgggagtc ctgatccttc
241 agtagcccaa gaaatgaaca cgtttattag tttgtggaaa gagaaaacaa atgagacttt
301 tgaggaagtg attgagaaga gtaaagtagt gctaaattta attgagaaat tgaaatttat
361 tttactggaa actccaccat gtgatttgca agataaaaat ataatacagt accaagaatc
421 aatactacaa ctgcaggagc tccttcatct taaattcggt gtagccacag aaatacttct
481 caaacaagct agtactttgg cagatctgga cagtggaaat atggaaaaag tcattaaaga
541 tgaaaatgtt actctgtatg tgtgggcaaa cctcaagaag aatccaaggc acagaagtgt
601 tagattctct gaaacacaaa ttggatttga gattccaagg atattagcaa caagtgacat
661 tgctgtacga ctcctgcata cccactatga tcatgtttct gcactgcacc ctgtttcaac
721 accatcaaaa gaatacactt ctgcagtaac tgagcttgtc aaagatgatg ttaagaatgt
781 agaaaaagca atcagcaagg aggtcgaaga agagtccaaa caacaagaaa gagggtctca
841 cttaattcag gaggaagaaa taaaagttga ggaggaacaa ggtgatattg aagtgaaaat
901 gagttctgct gaggaagaat ctgaagccat aaaatgtgaa cgagagatga aagtattaag
961 tgaaactgtt tcagcagcac agttgttgct ggtagagaat tcttctgaaa agccagattt
1021 ctttgaagac aatgtggtgg atttatgcca gttcacaact ctgggtggag tataccactt
1081 ggatattttg gagcttcctc cacagtgtaa accagtgaag ggatggatga ttgtggaaat
1141 actcaaagaa ggattacaga aatacacata tcctccggaa actacagaag agtttgagac
1201 agaaaatgct ttcccaccta tagaggtcac acttgaggtt catgagaatg taatcttttt
1261 tgaggatcct gtggttgtaa ggtgggatgc tgaaggtaaa cattggagaa ctgatggcat
1321 cagcaatgta tcctacaaac caaaagaaag acttgtaaca ttcagcctgg acacctttgg
1381 ccctgttacc ttgattcaag atgctcatat taacatgccg taccagtcat gggaactaag
1441 accacttgat gtaaataaag tacttttaac tgtgactaca gtatttactg agattcaaat
1501 acaaattaag gaaaacctct gcatgttatc ttcaatcaaa ctaaaagaca agaaacacat
1561 ctctattttg gaaggaacct ggatgactcc tattcctttc attattgctt tgaaagaagc
1621 tggactgaat atctttccta ctagacactc tcatttttat gttattataa acaataaggt
1681 tcctttggta gaagtgaaag cttatcgaca gatggcccta ctaagttctg cttttgcatt
1741 tggttggagc aagtggaacc tactatgtaa ttctacaaaa gtcgtattta aggtgaggga
1801 acaccttact gaagaatgta ctgagaatcc taattgggcc cttttaatgt ttagtggtga
1861 cagagcacaa agactgaaga tcaaggaaga gagtgaggca ttttctgaag cacttaaaga
1921 agaaactgag tttcattcta ctttatatca catggtgaag gattttgctt ctgaggaagc
1981 aatggagaaa gtcaggagtt ccaactgtca gtttgtcaac tctgtgtgcc acatgctgct
2041 ctctaccaga ttgctcagct actcctaacc tccacttaca aactgtattg taagtatgaa
2101 gaaccaagca tggtgaaa
//