LOCUS BC114930 6175 bp mRNA linear HUM 29-JUN-2006
DEFINITION Homo sapiens AF4/FMR2 family, member 1, mRNA (cDNA clone MGC:134969
IMAGE:40074243), complete cds.
ACCESSION BC114930
VERSION BC114930.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6175)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 6175)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (13-APR-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCG Plate: 2 Row: h Column: 12.
FEATURES Location/Qualifiers
source 1..6175
/db_xref="H-InvDB:HIT000387298"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:134969 IMAGE:40074243"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_283"
/note="Vector: pCR-Blunt II-TOPO with reversed insert"
gene 1..6175
/gene="AFF1"
/gene_synonym="AF-4"
/gene_synonym="AF4"
/gene_synonym="AF4-MLL"
/gene_synonym="MLL/AF4"
/db_xref="GeneID:4299"
/db_xref="HGNC:HGNC:7135"
/db_xref="MIM:159557"
CDS 411..4046
/gene="AFF1"
/gene_synonym="AF-4"
/gene_synonym="AF4"
/gene_synonym="AF4-MLL"
/gene_synonym="MLL/AF4"
/codon_start=1
/product="AF4/FMR2 family, member 1"
/protein_id="AAI14931.1"
/db_xref="GeneID:4299"
/db_xref="HGNC:HGNC:7135"
/db_xref="MIM:159557"
/translation="MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEP
YKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSI
PSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLT
QDRLGQEGFGSSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQ
QTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPP
PSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAK
LTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDS
QHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPP
TTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKS
SSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGE
REPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKA
LSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLP
LPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHS
SEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPS
SQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPK
QRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAK
KMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIM
SLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVA
QAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSY
VTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQL
QELTKTP"
BASE COUNT 1692 a 1648 c 1428 g 1407 t
ORIGIN
1 caccctttct aactgtggcc cgcgttgtgc tgttgctggg caggcgttgg gcgctggcgg
61 tcttcgagcg tgggggcccg ctggctttcc cttctcagaa actgcgccgg gggcgctcgc
121 ttgccccgga ttcggacgcg gcgctccccg ggctcgtctg aagtgcagat cgccgcagag
181 gccccagtgc ccggatgtcc atcaggatta gcgcgagcca atacgggccg agcccggggc
241 tgcgccgagg acgcccgggg ctcgagagca ggtagtcccg taacatcggg gcgccgcgcc
301 gggacgcgtc cccgcccggc tccgccaaat ggtgagcgcg gcgctggcag cagggcccgc
361 ggggtgaagg cgctcatgga cggaagaccc ctggctctat aagctgaatt atggcagccc
421 agtcaagttt gtacaatgac gacagaaacc tgcttcgaat tagagagaag gaaagacgca
481 accaggaagc ccaccaagag aaagaggcat ttcctgaaaa gattcccctt tttggagagc
541 cctacaagac agcaaaaggt gatgagctgt ctagtcgaat acagaacatg ttgggaaact
601 acgaagaagt gaaggagttc cttagtacta agtctcacac tcatcgcctg gatgcttctg
661 aaaataggtt gggaaagccg aaatatcctt taattcctga caaagggagc agcattccat
721 ccagctcctt ccacactagt gtccaccacc agtccattca cactcctgcg tctggaccac
781 tttctgttgg caacattagc cacaatccaa agatggcgca gccaagaact gaaccaatgc
841 caagtctcca tgccaaaagc tgcggcccac cggacagcca gcacctgacc caggatcgcc
901 ttggtcagga ggggttcggc tctagtcatc acaagaaagg tgaccgaaga gctgacggag
961 accactgtgc ttcggtgaca gattcggctc cagagaggga gctttctccc ttaatctctt
1021 tgccttcccc agttccccct ttgtcaccta tacattccaa ccagcaaact cttccccgga
1081 cgcaaggaag cagcaaggtt catggcagca gcaataacag taaaggctat tgcccagcca
1141 aatctcccaa ggacctagca gtgaaagtcc atgataaaga gacccctcaa gacagtttgg
1201 tggcccctgc ccagccgcct tctcagacat ttccacctcc ctccctcccc tcaaaaagtg
1261 ttgcaatgca gcagaagccc acggcttatg tccggcccat ggatggtcaa gatcaggccc
1321 ctagtgaatc ccctgaactg aaaccactgc cggaggacta tcgacagcag acctttgaaa
1381 aaacagactt gaaagtgcct gccaaagcca agctcaccaa actgaagatg ccttctcagt
1441 cagttgagca gacctactcc aatgaagtcc attgtgttga agagattctg aaggaaatga
1501 cccattcatg gccgcctcct ttgacagcaa tacatacgcc tagtacagct gagccatcca
1561 agtttccttt ccctacaaag gactctcagc atgtcagttc tgtaacccaa aaccaaaaac
1621 aatatgatac atcttcaaaa actcactcaa attctcagca aggaacgtca tccatgctcg
1681 aagacgacct tcagctcagt gacagtgagg acagtgacag tgaacaaacc ccagagaagc
1741 ctccctcctc atctgcacct ccaagtgctc cacagtccct tccagaacca gtggcatcag
1801 cacattccag cagtgcagag tcagaaagca ccagtgactc agacagttcc tcagactcag
1861 agagcgagag cagttcaagt gacagcgaag aaaatgagcc cctagaaacc ccagctccgg
1921 agcctgagcc tccaacaaca aacaaatggc agctggacaa ctggctgacc aaagtcagcc
1981 agccagctgc gccaccagag ggccccagga gcacagagcc cccacggcgg cacccagaga
2041 gtaagggcag cagcgacagt gccacgagtc aggagcattc tgaatccaaa gatcctcccc
2101 ctaaaagctc cagcaaagcc ccccgggccc cacccgaagc cccccacccc ggaaagagga
2161 gctgtcagaa gtctccggca cagcaggagc ccccacaaag gcaaaccgtt ggaaccaaac
2221 aacccaaaaa acctgtcaag gcctctgccc gggcaggttc acggaccagc ctgcaggggg
2281 aaagggagcc agggcttctt ccctatggct cccgagacca gacttccaaa gacaagccca
2341 aggtgaagac gaaaggacgg ccccgggccg cagcaagcaa cgaacccaag ccagcagtgc
2401 ccccctccag tgagaagaag aagcacaaga gctccctccc tgccccctct aaggctctct
2461 caggcccaga acccgcgaag gacaatgtgg aggacaggac ccctgagcac tttgctcttg
2521 ttcccctgac tgagagccag ggcccacccc acagtggcag cggcagcagg actagtggct
2581 gccgccaagc cgtggtggtc caggaggaca gccgcaaaga cagactccca ttgcctttga
2641 gagacaccaa gctgctctca ccgctcaggg acactcctcc cccacaaagc ttgatggtga
2701 agatcaccct agacctgctc tctcggatac cccagcctcc cgggaagggg agccgccaga
2761 ggaaagcaga agataaacag ccgcccgcag ggaagaagca cagctctgag aagaggagct
2821 cagacagctc aagcaagttg gccaaaaaga gaaagggtga agcagaaaga gactgtgata
2881 acaagaaaat cagactggag aaggaaatca aatcacagtc atcttcatct tcatcctccc
2941 acaaagaatc ttctaaaaca aagccctcca ggccctcctc acagtcctca aagaaggaaa
3001 tgctcccccc gccacccgtg tcctcgtcct cccagaagcc agccaagcct gcacttaaga
3061 ggtcaaggcg ggaagcagac acctgtggcc aggaccctcc caaaagtgcc agcagtacca
3121 agagcaacca caaagactct tccattccca agcagagaag agtagagggg aagggctcca
3181 gaagctcctc ggagcacaag ggttcttccg gagatactgc aaatcctttt ccagtgcctt
3241 ctttgccaaa tggtaactct aaaccaggga agcctcaagt gaagtttgac aaacaacaag
3301 cagaccttca catgagggag gcaaaaaaga tgaagcagaa agcagagtta atgacggaca
3361 gggttggaaa ggcttttaag tacctggaag ccgtcttgtc cttcattgag tgcggaattg
3421 ccacagagtc tgaaagccag tcatccaagt cagcttactc tgtctactca gaaactgtag
3481 atctcattaa attcataatg tcattaaaat ccttctcaga tgccacagcg ccaacacaag
3541 agaaaatatt tgctgtttta tgcatgcgtt gccagtccat tttgaacatg gcgatgtttc
3601 gttgtaaaaa agacatagca ataaagtatt ctcgtactct taataaacac ttcgagagtt
3661 cttccaaagt cgcccaggca ccttctccat gcattgcaag aagcacaggc acaccatccc
3721 ctctttcccc aatgccttct cctgccagct ccgtagggtc ccagtcaagt gctggcagtg
3781 tggggagcag tggggtggct gccactatca gcaccccagt caccatccag aatatgacat
3841 cttcctatgt caccatcaca tcccatgttc ttaccgcctt tgacctttgg gaacaggccg
3901 aggccctcac gaggaagaat aaagaattct ttgctcggct cagcacaaat gtgtgcacct
3961 tggccctcaa cagcagtttg gtggacctgg tgcactatac acgacagggt tttcagcagc
4021 tacaagaatt aaccaaaaca ccttaatgga gccccaggtt gattcaatgc cttgggaact
4081 atttttgcac attggaagcc tcaaaaacag tccagacgtt tgtttcatca ggacaccaaa
4141 ctctaaaaaa gaagcaccac gagatggcca ggacatttgt ccacttaaac tctcaacaac
4201 agtgtgatca ttggttggac actgtggtta tgcagaagca gagatgagga ggctggcccc
4261 agagatgatc ttgcccttcc taactaaagg acagaagtgc aatttagctt aaatgggtgt
4321 atgaatggtc tagaaacatt tctatttttt ttttaaacca gcaggataca agttgcaaat
4381 gaaatgagga gaaacagttt caactctgaa agtgaatttc acgtcatctc agtagccacg
4441 ctagtccatt cccagaagga aatttttttt tttaacaatg acttttggta aagggttttg
4501 tggatgattt tttttctttt gagttttggg agaaatattt gtttagtaac ttctaatggc
4561 catctgtaaa ccataagtaa tgaaggactc cactgtgccc cactttctgc caatgaacag
4621 tggcttgata ataccaagta ttgttgtaat ttataaaatt gaaggcaacc cccgctcctg
4681 ccgcccccaa tctccccatt gcctagagcg ctgcacattg accccagctc tgacttctca
4741 ttactgtgct gaaagtcagc ccacgtcgga gcggtgagga ggagccacag cacatggggt
4801 gccacctcga ggtctgcaca ggaggacttg gcgctgccat ttcctacccc tgccatttcc
4861 cacccctgct tcagcgaaag ggactctcta acagggcagt cactgttgac tctattctga
4921 atttcctccc ttggggaaga agggaaccaa catttatacc tgaccagatg gctaaagtgc
4981 ttttaaagtt ttgtttaagt agagctggaa tttgaggtgc tgatctgtgg tctacagtta
5041 tgtggtaact catgttgtcc agccaactca gagtttcgtc agtgaacaag aaacatgaaa
5101 tctgcttctt agagaggcta tatttttctg ctacaaatat tttatattta tagcaaaact
5161 agactttcag agtccttgat tgtctagggg aagttaactc cctgagagga tgtagagatt
5221 tggggtggtt gattagactt ttgaaaaact catcaccaca tgccttcact ccagagtgtt
5281 ctcagctaga tttgatttgg ttgaggagga actgtggccc tccgtaagtt attgccatag
5341 tgtatgcatt aaaccaagtc cattttgaat gacctaaaat gaagtaacac aatcagaaat
5401 cccatgtgcc cataagcaca gatttttctt tttcattgaa actttaaagg ttattattgg
5461 aaacattact ttgagtgcag tgtttttaaa agccaattct tttttatccc ttttagaagt
5521 agaatttgca cagttactac aattgaggag tgtcatctct ataacttttt ctccgccttt
5581 gtcccattct gcccctgtac atgtttccta ccaagcatgt ttcacatttt cctattagtg
5641 gaggagggag aaccatattt atttataatg aagacatcta agatccctat gatgaatgca
5701 ggaactctct tggtagtttg taaatacaca aagggatgtg tcgagggatg ggagcgatgc
5761 ttatctctca cagtgtgagt ggtctgtgtg aggctgttcc ttcagtttct tctccagact
5821 gttctttggt tgtcactaag tcagaggtct ggtccctcat gtttaggtga aagccagaga
5881 atgacagctg tagtcatatc tgagcataag accttgatgt gtgattcctg atgaccggtt
5941 tcatttattc atgttataaa gcaaagccct ggtccttttt aaactactag ttttaaaaac
6001 ctgtgttaaa tgaacagtaa ttgcctggta ggtttggtgt gtgtgtagca ttgtgtgtcc
6061 atctgttata tgtaaaggac aaggcaccag aatcaggctt tatttcgata ttgaagatgt
6121 tatttaacat ctttcttttt tccttactcc cttagccatc ccctcccctt ttgtc
//