LOCUS BC114432 3218 bp mRNA linear HUM 21-JUL-2006
DEFINITION Homo sapiens phosphoinositide-3-kinase, catalytic, beta
polypeptide, mRNA (cDNA clone MGC:133043 IMAGE:40008544), complete
cds.
ACCESSION BC114432
VERSION BC114432.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3218)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3218)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (10-MAR-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 17 Row: b Column: 1.
FEATURES Location/Qualifiers
source 1..3218
/db_xref="H-InvDB:HIT000340671"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:133043 IMAGE:40008544"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_283"
/note="Vector: pCR-Blunt II-TOPO with reversed insert;
Clone identification sequence tag: TTTGAGAA"
gene 1..3218
/gene="PIK3CB"
/gene_synonym="p110-BETA"
/gene_synonym="PI3K"
/gene_synonym="PI3Kbeta"
/db_xref="GeneID:5291"
/db_xref="HGNC:HGNC:8976"
/db_xref="MIM:602925"
CDS 5..3217
/gene="PIK3CB"
/gene_synonym="p110-BETA"
/gene_synonym="PI3K"
/gene_synonym="PI3Kbeta"
/codon_start=1
/product="phosphoinositide-3-kinase, catalytic, beta
polypeptide"
/protein_id="AAI14433.1"
/db_xref="GeneID:5291"
/db_xref="HGNC:HGNC:8976"
/db_xref="MIM:602925"
/translation="MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQL
EVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDV
RPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKI
LSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNM
NPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNR
ALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQ
IVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINIC
DLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG
QLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPF
DKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCR
EIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV
GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEV
HIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKE
AMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGED
SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVST
SETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYV
LGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGK
TGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLAL
GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS"
BASE COUNT 980 a 615 c 704 g 919 t
ORIGIN
1 caccatgtgc ttcagtttca taatgcctcc tgctatggca gacatccttg acatctgggc
61 ggtggattca cagatagcat ctgatggctc catacctgtg gatttccttt tgcccactgg
121 gatttatatc cagttggagg tacctcggga agctaccatt tcttatatta agcagatgtt
181 atggaagcaa gttcacaatt acccaatgtt caacctcctt atggatattg actcctatat
241 gtttgcatgt gtgaatcaga ctgctgtata tgaggagctt gaagatgaaa cacgaagact
301 ctgtgatgtc agaccttttc ttccagttct caaattagtg acaagaagtt gtgacccagg
361 ggaaaaatta gactcaaaaa ttggagtcct tataggaaaa ggtctgcatg aatttgattc
421 cttgaaggat cctgaagtaa atgaatttcg aagaaaaatg cgcaaattca gcgaggaaaa
481 aatcctgtca cttgtgggat tgtcttggat ggactggcta aaacaaacat atccaccaga
541 gcatgaacca tccatccctg aaaacttaga agataaactt tatgggggaa agctcatcgt
601 agctgttcat tttgaaaact gccaggacgt gtttagcttt caagtgtctc ctaatatgaa
661 tcctatcaaa gtaaatgaat tggcaatcca aaaacgtttg actattcatg ggaaggaaga
721 tgaagttagc ccctatgatt atgtgttgca agtcagcggg agagtagaat atgtttttgg
781 tgatcatcca ctaattcagt tccagtatat ccggaactgt gtgatgaaca gagccctgcc
841 ccattttata cttgtggaat gctgcaagat caagaaaatg tatgaacaag aaatgattgc
901 catagaggct gccataaatc gaaattcatc taatcttcct cttccattac caccaaagaa
961 aacacgaatt atttctcatg tttgggaaaa taacaaccct ttccaaattg tcttggttaa
1021 gggaaataaa cttaacacag aggaaactgt aaaagttcat gtcagggctg gtctttttca
1081 tggtactgag ctcctgtgta aaaccatcgt aagctcagag gtatcaggga aaaatgatca
1141 tatttggaat gaaccactgg aatttgatat taatatttgt gacttaccaa gaatggctcg
1201 attatgtttt gctgtttatg cagttttgga taaagtaaaa acgaagaaat caacgaaaac
1261 tattaatccc tctaaatatc agaccatcag gaaagctgga aaagtgcatt atcctgtagc
1321 gtgggtaaat acgatggttt ttgactttaa aggacaattg agaactggag acataatatt
1381 acacagctgg tcttcatttc ctgatgaact cgaagaaatg ttgaatccaa tgggaactgt
1441 tcaaacaaat ccatatactg aaaatgcaac agctttgcat gttaaatttc cagagaataa
1501 aaaacaacct tattattacc ctcccttcga taagattatt gaaaaggcag ctgagattgc
1561 aagcagtgat agtgctaatg tgtcaagtcg aggtggaaaa aagtttcttc ctgtattgaa
1621 agaaatcttg gacagggatc ccttgtctca actgtgtgaa aatgaaatgg atcttatttg
1681 gactttgcga caagactgcc gagagatttt cccacaatca ctgccaaaat tactgctgtc
1741 aatcaagtgg aataaacttg aggatgttgc tcagcttcag gcgctgcttc agatttggcc
1801 taaactgccc ccccgggagg ccctagagct tctggatttc aactatccag accagtacgt
1861 tcgagaatat gctgtaggct gcctgcgaca gatgagtgat gaagaacttt ctcaatatct
1921 tttacaactg gtgcaagtgt taaaatatga gccttttctt gattgtgccc tctctagatt
1981 cctattagaa agagcacttg gtaatcggag gatagggcag tttctatttt ggcatcttag
2041 gtcagaagtg cacattcctg ctgtctcagt acaatttggt gtcatccttg aagcatactg
2101 ccggggaagt gtggggcaca tgaaagtgct ttctaagcag gttgaagcac tcaataagtt
2161 aaaaacttta aatagtttaa tcaaactgaa tgccgtgaag ttaaacagag ccaaagggaa
2221 ggaggccatg catacctgtt taaaacagag tgcttaccgg gaagccctct ctgacctgca
2281 gtcacccctg aacccatgtg ttatcctctc agaactctat gttgaaaagt gcaaatacat
2341 ggattccaaa atgaagcctt tgtggctggt atacaataac aaggtatttg gtgaggattc
2401 agttggagtg atttttaaaa atggtgatga tttacgacag gatatgttga cactccaaat
2461 gttgcgcttg atggatttac tctggaaaga agctggtttg gatcttcgga tgttgcctta
2521 tggctgttta gcaacaggag atcgctctgg cctcattgaa gttgtgagca cctctgaaac
2581 aattgctgac attcagctga acagtagcaa tgtggctgct gcagcagcct tcaacaaaga
2641 tgcccttctg aactggctta aagaatacaa ctctggggat gacctggacc gagccattga
2701 ggaatttaca ctgtcctgtg ctggctactg tgtagcttct tatgtccttg ggattggtga
2761 cagacatagt gacaacatca tggtcaaaaa aactggccag ctcttccaca ttgactttgg
2821 acatattctt ggaaatttca aatctaagtt tggcattaaa agggagcgag tgccttttat
2881 tcttacctat gatttcatcc atgtcattca acaaggaaaa acaggaaata cagaaaagtt
2941 tggccggttc cgccagtgtt gtgaggatgc atatctgatt ttacgacggc atgggaatct
3001 cttcatcact ctctttgcgc tgatgttgac tgcagggctt cctgaactca catcagtcaa
3061 agatatacag tatcttaagg actctcttgc attagggaag agtgaagaag aagcactcaa
3121 acagtttaag caaaaatttg atgaggcgct cagggaaagc tggactacta aagtgaactg
3181 gatggcccac acagttcgga aagactacag atcttaat
//