LOCUS       BC112263                3054 bp    mRNA    linear   HUM 21-JAN-2006
DEFINITION  Homo sapiens polycystic kidney disease 2 (autosomal dominant), mRNA
            (cDNA clone MGC:138468 IMAGE:8327731), complete cds.
ACCESSION   BC112263
VERSION     BC112263.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3054)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2006) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Mike Brownstein, NIMH
            cDNA Library Preparation: British Columbia Cancer Research Center
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRCB Plate: 4 Row: n Column: 17.
FEATURES             Location/Qualifiers
     source          1..3054
                     /db_xref="H-InvDB:HIT000340392"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:138468 IMAGE:8327731"
                     /tissue_type="Pooled,bladder, uterus, placenta, PCR
                     rescued clones"
                     /clone_lib="NIH_MGC_350"
                     /lab_host="DH10B"
                     /note="Vector: pCR4-TOPO with reversed insert; Clone
                     identification sequence tag: CTCAGCTC"
     gene            1..3054
                     /gene="PKD2"
                     /gene_synonym="APKD2"
                     /gene_synonym="PKD4"
                     /db_xref="GeneID:5311"
                     /db_xref="HGNC:HGNC:9009"
                     /db_xref="IMGT/GENE-DB:9009"
                     /db_xref="MIM:173910"
     CDS             88..2994
                     /gene="PKD2"
                     /gene_synonym="APKD2"
                     /gene_synonym="PKD4"
                     /codon_start=1
                     /product="polycystin 2"
                     /protein_id="AAI12264.1"
                     /db_xref="GeneID:5311"
                     /db_xref="HGNC:HGNC:9009"
                     /db_xref="IMGT/GENE-DB:9009"
                     /db_xref="MIM:173910"
                     /translation="MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPG
                     GLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEE
                     VEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQ
                     GPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLK
                     SVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSM
                     EDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIP
                     QDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYY
                     LDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGG
                     VIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWN
                     CLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTV
                     FFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVD
                     DFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIIND
                     TYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDE
                     LRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPR
                     PMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSI
                     VSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELE
                     RWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV"
BASE COUNT          753 a          724 c          870 g          707 t
ORIGIN      
        1 gcgccgggaa gaaaggaaca tggctcctga ggcgcacagc gccgagcgcg gcgccgcgca
       61 cccgcgcgcc ggacgccagt gaccgcgatg gtgaactcca gtcgcgtgca gcctcagcag
      121 cccggggacg ccaagcggcc gcccgcgccc cgcgcgccgg acccgggccg gctgatggct
      181 ggctgcgcgg ccgtgggcgc cagcctcgcc gccccgggcg gcctctgcga gcagcggggc
      241 ctggagatcg agatgcagcg catccggcag gcggccgcgc gggacccccc ggccggagcc
      301 gcggcctccc cttctcctcc gctctcgtcg tgctcccggc aggcgtggag ccgcgataac
      361 cccggcttcg aggccgagga ggaggaggag gaggtggaag gggaagaagg cggaatggtg
      421 gtggagatgg acgtagagtg gcgcccgggc agccggaggt cggccgcctc ctcggccgtg
      481 agctccgtgg gcgcgcggag ccgggggctt gggggctacc acggcgcggg ccacccgagc
      541 gggaggcggc gccggcgaga ggaccagggc ccgccgtgcc ccagcccagt cggcggcggg
      601 gacccgctgc atcgccacct ccccctggaa gggcagccgc cccgagtggc ctgggcggag
      661 aggctggttc gcgggctgcg aggtctctgg ggaacaagac tcatggagga aagcagcact
      721 aaccgagaga aataccttaa aagtgtttta cgggaactgg tcacatacct cctttttctc
      781 atagtcttgt gcatcttgac ctacggcatg atgagctcca atgtgtacta ctacacccgg
      841 atgatgtcac agctcttcct agacaccccc gtgtccaaaa cggagaaaac taactttaaa
      901 actctgtctt ccatggaaga cttctggaag ttcacagaag gctccttatt ggatgggctg
      961 tactggaaga tgcagcccag caaccagact gaagctgaca accgaagttt catcttctat
     1021 gagaacctgc tgttaggggt tccacgaata cggcaactcc gagtcagaaa tggatcctgc
     1081 tctatccccc aggacttgag agatgaaatt aaagagtgct atgatgtcta ctctgtcagt
     1141 agtgaagata gggctccctt tgggccccga aatggaaccg cttggatcta cacaagtgaa
     1201 aaagacttga atggtagtag ccactgggga atcattgcaa cttatagtgg agctggctat
     1261 tatctggatt tgtcaagaac aagagaggaa acagctgcac aagttgctag cctcaagaaa
     1321 aatgtctggc tggaccgagg aaccagggca acttttattg acttctcagt gtacaacgcc
     1381 aacattaacc tgttctgtgt ggtcaggtta ttggttgaat tcccagcaac aggtggtgtg
     1441 attccatctt ggcaatttca gcctttaaag ctgatccgat atgtcacaac ttttgatttc
     1501 ttcctggcag cctgtgagat tatcttttgt ttctttatct tttactatgt ggtggaagag
     1561 atattggaaa ttcgcattca caaactacac tatttcagga gtttctggaa ttgtctggat
     1621 gttgtgatcg ttgtgctgtc agtggtagct ataggaatta acatatacag aacatcaaat
     1681 gtggaggtgc tactacagtt tctggaagat caaaatactt tccccaactt tgagcatctg
     1741 gcatattggc agatacagtt caacaatata gctgctgtca cagtattttt tgtctggatt
     1801 aagctcttca aattcatcaa ttttaacagg accatgagcc agctctcgac aaccatgtct
     1861 cgatgtgcca aagacctgtt tggctttgct attatgttct tcattatttt cctagcgtat
     1921 gctcagttgg cataccttgt ctttggcact caggtcgatg acttcagtac tttccaagag
     1981 tgtatcttca ctcaattccg tatcattttg ggcgatatca actttgcaga gattgaggaa
     2041 gctaatcgag ttttgggacc aatttatttc actacatttg tgttctttat gttcttcatt
     2101 cttttgaata tgtttttggc tatcatcaat gatacttact ctgaagtgaa atctgacttg
     2161 gcacagcaga aagctgaaat ggaactctca gatcttatca gaaagggcta ccataaagct
     2221 ttggtcaaac taaaactgaa aaaaaatacc gtggatgaca tttcagagag tctgcggcaa
     2281 ggaggaggca agttaaactt tgacgaactt cgacaagatc tcaaagggaa gggccatact
     2341 gatgcagaga ttgaggcaat attcacaaag tacgaccaag atggagacca agaactgacc
     2401 gaacatgaac atcagcagat gagagacgac ttggagaaag agagggagga cctggatttg
     2461 gatcacagtt ctttaccacg tcccatgagc agccgaagtt tccctcgaag cctggatgac
     2521 tctgaggagg atgacgatga agatagcgga catagctcca gaaggagggg aagcatttct
     2581 agtggcgttt cttacgaaga gtttcaagtc ctggtgagac gagtggaccg gatggagcat
     2641 tccatcggca gcatagtgtc caagattgac gccgtgatcg tgaagctaga gattatggag
     2701 cgagccaaac tgaagaggag ggaggtgctg ggaaggctgt tggatggggt ggccgaggat
     2761 gaaaggctgg gtcgtgacag tgaaatccat agggaacaga tggaacggct agtacgtgaa
     2821 gagttggaac gctgggaatc cgatgatgca gcttcccaga tcagtcatgg tttaggcacg
     2881 ccagtgggac taaatggtca acctcgcccc agaagctccc gcccatcttc ctcccaatct
     2941 acagaaggca tggaaggtgc aggtggaaat gggagttcta atgtccacgt atgatatgtg
     3001 tgtttcagta tgtgtgtttc taataagtga ggaagtggct gtcctgaatt gctg
//