LOCUS BC109077 2402 bp mRNA linear HUM 04-OCT-2006
DEFINITION Homo sapiens IL2-inducible T-cell kinase, mRNA (cDNA clone
MGC:126257 IMAGE:40034274), complete cds.
ACCESSION BC109077
VERSION BC109077.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2402)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2402)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (03-NOV-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 4, 2006 this sequence version replaced BC109077.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 14 Row: I Column: 7.
FEATURES Location/Qualifiers
source 1..2402
/db_xref="H-InvDB:HIT000339246"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:126257 IMAGE:40034274"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_283"
/note="Vector: pCR-Blunt II-TOPO with reversed insert;
Clone identification sequence tag: NA"
gene 1..2402
/gene="ITK"
/gene_synonym="EMT"
/gene_synonym="LYK"
/gene_synonym="PSCTK2"
/db_xref="GeneID:3702"
/db_xref="HGNC:HGNC:6171"
/db_xref="MIM:186973"
CDS 74..1936
/gene="ITK"
/gene_synonym="EMT"
/gene_synonym="LYK"
/gene_synonym="PSCTK2"
/codon_start=1
/product="IL2-inducible T-cell kinase"
/protein_id="AAI09078.1"
/db_xref="GeneID:3702"
/db_xref="HGNC:HGNC:6171"
/db_xref="MIM:186973"
/translation="MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDR
HGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRW
VLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPT
PEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHE
GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVS
VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRL
RYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKT
IREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ
RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL
DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE
VVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL"
BASE COUNT 662 a 558 c 618 g 564 t
ORIGIN
1 tgccccaaaa ctctttcctt tggttgtgct aagaggtgat gcccaaggtg caccaccttt
61 caagaactgg atcatgaaca actttatcct cctggaagaa cagctcatca agaaatccca
121 acaaaagaga agaacttctc cctcgaactt taaagtccgc ttctttgtgt taaccaaagc
181 cagcctggca tactttgaag atcgtcatgg gaagaagcgc acgctgaagg ggtccattga
241 gctctcccga atcaaatgtg ttgagattgt gaaaagtgac atcagcatcc catgccacta
301 taaatacccg tttcaggtgg tgcatgacaa ctacctccta tatgtgtttg ctccagatcg
361 tgagagccgg cagcgctggg tgctggccct taaagaagaa acgaggaata ataacagttt
421 ggtgcctaaa tatcatccta atttctggat ggatgggaag tggaggtgct gttctcagct
481 ggagaagctt gcaacaggct gtgcccaata tgatccaacc aagaatgctt caaagaagcc
541 tcttcctcct actcctgaag acaacaggcg accactttgg gaacctgaag aaactgtggt
601 cattgcctta tatgactacc aaaccaatga tcctcaggaa ctcgcactgc ggcgcaacga
661 agagtactgc ctgctggaca gttctgagat tcactggtgg agagtccagg acaggaatgg
721 gcatgaagga tatgtaccaa gcagttatct ggtggaaaaa tctccaaata atctggaaac
781 ctatgagtgg tacaataaga gtatcagccg agacaaagct gaaaaacttc ttttggacac
841 aggcaaagaa ggagccttca tggtaaggga ttccaggact gcaggaacat acaccgtgtc
901 tgttttcacc aaggctgttg taagtgagaa caatccctgt ataaagcatt atcacatcaa
961 ggaaacaaat gacaatccta agcgatacta tgtggctgaa aagtatgtgt tcgattccat
1021 ccctcttctc atcaactatc accaacataa tggaggaggc ctggtgactc gactccggta
1081 tccagtttgt tttgggaggc agaaagcccc agttacagca gggctgagat acgggaaatg
1141 ggtgatcgac ccctcagagc tcacttttgt gcaagagatt ggcagtgggc aatttgggtt
1201 ggtgcatctg ggctactggc tcaacaagga caaggtggct atcaaaacca ttcgggaagg
1261 ggctatgtca gaagaggact tcatagagga ggctgaagta atgatgaaac tctctcatcc
1321 caaactggtg cagctgtatg gggtgtgcct ggagcaggcc cccatctgcc tggtgtttga
1381 gttcatggag cacggctgcc tgtcagatta tctacgcacc cagcggggac tttttgctgc
1441 agagaccctg ctgggcatgt gtctggatgt gtgtgagggc atggcctacc tggaagaggc
1501 atgtgtcatc cacagagact tggctgccag aaattgtttg gtgggagaaa accaagtcat
1561 caaggtgtct gactttggga tgacaaggtt cgttctggat gatcagtaca ccagttccac
1621 aggcaccaaa ttcccggtga agtgggcatc cccagaggtt ttctctttca gtcgctatag
1681 cagcaagtcc gatgtgtggt catttggtgt gctgatgtgg gaagttttca gtgaaggcaa
1741 aatcccgtat gaaaaccgaa gcaactcaga ggtggtggaa gacatcagta ccggatttcg
1801 gttgtacaag ccccggctgg cctccacaca cgtctaccag attatgaatc actgctggaa
1861 agagagacca gaagatcggc cagccttctc cagactgctg cgtcaactgg ctgaaattgc
1921 agaatcagga ctttagtaga gactgagtac caggccacgg gctgcagatc ctgaatggag
1981 gaaggatatg tcctcattcc atagagcatt agaagctgcc accagcccag gaccctccag
2041 aggcagcctg gcctgtggca tcagtccctg agtcaccatg gaagcagcat cctgaccaca
2101 gctggcagtc aagccacagc tggagggtca gccaccaagc tgggagctga gccagaacag
2161 gagtgatgtc tctgcccttc ctctagcctc ttgtcacatg tggtgcacaa acctcaacct
2221 gacagctttc agacagcatt cttgcacttc ttagcaacag agagagacat gagtaagacc
2281 cagattgcta tttttattgt tatttttaac atgaatctaa agtttatggt tccagggact
2341 ttttatttga cccaacaaca cagtatccca ggatatggag gcaaggggaa caaagagcag
2401 gg
//