LOCUS BC107877 2397 bp mRNA linear HUM 06-JUN-2006
DEFINITION Homo sapiens tyrosyl-DNA phosphodiesterase 1, mRNA (cDNA clone
MGC:104252 IMAGE:6597752), complete cds.
ACCESSION BC107877
VERSION BC107877.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2397)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2397)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-OCT-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: NCI
cDNA Library Preparation: Michael Brownstein / Ted Usdin
Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 61 Row: j Column: 2
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 57242803.
FEATURES Location/Qualifiers
source 1..2397
/db_xref="H-InvDB:HIT000338965"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:104252 IMAGE:6597752"
/tissue_type="Pooled, 40 cell lines"
/clone_lib="NIH_MGC_128"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..2397
/gene="TDP1"
/gene_synonym="FLJ11090"
/db_xref="GeneID:55775"
/db_xref="HGNC:HGNC:18884"
/db_xref="MIM:607198"
CDS 304..2073
/gene="TDP1"
/gene_synonym="FLJ11090"
/codon_start=1
/product="TDP1 protein"
/protein_id="AAI07878.1"
/db_xref="GeneID:55775"
/db_xref="HGNC:HGNC:18884"
/db_xref="MIM:607198"
/translation="MSQEVDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEP
RYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQ
KQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDK
GNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPE
FRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLR
VVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLISYLMAYNAPS
LKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESW
PVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTS
LEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIA
WFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFAPAKRIKDEVEASFSGSR
QFQSETEVLRWQPGANGHLSCAI"
BASE COUNT 682 a 560 c 582 g 573 t
ORIGIN
1 ggggactgcg cgcatgcgcg gcggccgccg aaggggcggg atccgaggca agcgttggtt
61 ctgtgcgcct cagagttgga gcacacagct gtattaaaaa ggcaaatcga aggccgggcg
121 cggtgactca cgcctgtcat cctagcactt tgggaggccg aggcggctga atcacttgag
181 gttaggagtt tgagatcagc ccgggcaaca tggtgaaacc ccgtctctac aaaaatagaa
241 aaattagccg agcgtgatgg tggatgcctg taatcctagc tcctcgggag gctaaggagt
301 ataatgtctc aggaagtcga ttatgggagg tggaccatat ctagtagtga tgaaagtgag
361 gaagaaaagc caaaaccaga caagccatct acctcttctc ttctctgtgc caggcaagga
421 gcagcaaatg agcccaggta cacctgttcc gaggcccaga aagctgcaca caagaggaaa
481 atatcacctg tgaaattcag caatacagat tcagttttac ctcccaaaag gcagaaaagc
541 ggttcccagg aggacctcgg ctggtgtctg tccagcagtg atgatgagct gcaaccagaa
601 atgccgcaga agcaggctga gaaagtggtg atcaaaaagg agaaagacat ctctgctccc
661 aatgacggca ctgcccaaag aactgaaaat catggcgctc ccgcctgcca caggctcaaa
721 gaggaggaag acgagtatga gacatcaggg gagggccagg acatttggga catgctggat
781 aaagggaacc ccttccagtt ttacctcact agagtctctg gagttaagcc aaagtataac
841 tctggagccc tccacatcaa ggatatttta tctcctttat ttgggacgct tgtttcttca
901 gctcagttta actactgctt tgacgtggac tggctcgtaa aacagtatcc accagagttc
961 aggaagaagc caatcctgct tgtgcatggt gataagcgag aggctaaggc tcacctccat
1021 gcccaggcca agccttacga gaacatctct ctctgccagg caaagttgga tattgcgttt
1081 ggaacacacc acacgaaaat gatgctgctg ctctatgaag aaggcctccg ggttgtcata
1141 cacacctcca acctcatcca tgctgactgg caccagaaaa ctcaaggaat atggttgagc
1201 cccttatacc cacgaattgc tgatggaacc cacaaatctg gagagtcgcc aacacatttt
1261 aaagctgatc tcatcagtta cttgatggct tataatgccc cttctctcaa ggagtggata
1321 gatgtcattc acaagcacga tctctctgaa acaaatgttt atcttattgg ttcaacccca
1381 ggacgctttc aaggaagtca aaaagataat tggggacatt ttagacttaa gaagcttctg
1441 aaagaccatg cctcatccat gcctaacgca gagtcctggc ctgtcgtagg tcagttttca
1501 agcgttggct ccttgggagc cgatgaatca aagtggttat gttctgagtt taaagagagc
1561 atgctgacac tggggaagga aagcaagact ccaggaaaaa gctctgttcc tctttacttg
1621 atctatcctt ctgtggaaaa tgtgcggacc agtttagaag gatatcctgc tgggggctct
1681 cttccctata gcatccagac agctgaaaaa cagaattggc tgcattccta ttttcacaaa
1741 tggtcagctg agacttctgg ccgcagcaat gccatgccac atattaagac atatatgagg
1801 ccttctccag acttcagtaa aattgcttgg ttccttgtca caagcgcaaa tctgtccaag
1861 gctgcctggg gagcattgga gaagaatggc acccagctga tgatccgctc ctacgagctc
1921 ggggtccttt tcctcccttc agcatttgcc cctgcgaaga gaataaagga tgaagtggag
1981 gcttcgttct ctgggtctag acagtttcaa agtgaaacag aagttcttcg ctggcagcca
2041 ggagccaatg gccacctttc ctgtgccata tgatttgcct ccagaactgt atggaagtaa
2101 agatcggcca tggatatgga acattcctta tgtcaaagca ccggatacgc atgggaacat
2161 gtgggtgccc tcctgagaat cttgaggcac tgtgaaattt aagtgtaaga cattgagcca
2221 caaacatgga atctcttctt tgtactggat gtccacttcc cttaaagtct tatttgcacc
2281 cttacaaaat ctttccaaag gtcactctta tgaatggatg ttggttatac ttttaatgga
2341 cattaacatt cctaataaag tattagtttc taaaaaaaaa aaaaaaaaaa aaaaaaa
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