LOCUS BC106739 1336 bp mRNA linear HUM 04-AUG-2008
DEFINITION Homo sapiens tryptophan hydroxylase 1, mRNA (cDNA clone MGC:119994
IMAGE:40016887), complete cds.
ACCESSION BC106739
VERSION BC106739.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1336)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1336)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-OCT-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 13 Row: a Column: 3.
FEATURES Location/Qualifiers
source 1..1336
/db_xref="H-InvDB:HIT000338482"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:119994 IMAGE:40016887"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_283"
/note="Vector: pCR-Blunt II-TOPO with reversed insert;
Clone identification sequence tag: GATCAAT sequenced from
the forward primer"
gene 1..1336
/gene="TPH1"
/db_xref="GeneID:7166"
/db_xref="HGNC:HGNC:12008"
/db_xref="MIM:191060"
CDS 1..1335
/gene="TPH1"
/codon_start=1
/product="tryptophan hydroxylase 1"
/protein_id="AAI06740.1"
/db_xref="GeneID:7166"
/db_xref="HGNC:HGNC:12008"
/db_xref="MIM:191060"
/translation="MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVN
LLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGM
ETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDP
IPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVS
NFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLG
HVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGL
LSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKT
IKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI"
BASE COUNT 410 a 271 c 274 g 381 t
ORIGIN
1 atgattgaag acaataagga gaacaaagac cattccttag aaaggggaag agcaagtctc
61 attttttcct taaagaatga agttggagga cttataaaag ccctgaaaat ctttcaggag
121 aagcatgtga atctgttaca tatcgagtcc cgaaaatcaa aaagaagaaa ctcagaattt
181 gagatttttg ttgactgtga catcaacaga gaacaattga atgatatttt tcatctgctg
241 aagtctcata ccaatgttct ctctgtgaat ctaccagata attttacttt gaaggaagat
301 ggtatggaaa ctgttccttg gtttccaaag aagatttctg acctggacca ttgtgccaac
361 agagttctga tgtatggatc tgaactagat gcagaccatc ctggcttcaa agacaatgtc
421 taccgtaaac gtcgaaagta ttttgcggac ttggctatga actataaaca tggagacccc
481 attccaaagg ttgaattcac tgaagaggag attaagacct ggggaaccgt attccaagag
541 ctcaacaaac tctacccaac ccatgcttgc agagagtatc tcaaaaactt acctttgctt
601 tctaaatatt gtggatatcg ggaggataat atcccacaat tggaagatgt ctccaacttt
661 ttaaaagagc gtacaggttt ttccatccgt cctgtggctg gttacttatc accaagagat
721 ttcttatcag gtttagcctt tcgagttttt cactgcactc aatatgtgag acacagttca
781 gatcccttct ataccccaga gccagatacc tgccatgaac tcttaggtca tgtcccgctt
841 ttggctgaac ctagttttgc ccaattctcc caagaaattg gcttggcttc tcttggcgct
901 tcagaggagg ctgttcaaaa actggcaacg tgctactttt tcactgtgga gtttggtcta
961 tgtaaacaag atggacagct aagagtcttt ggtgctggct tactttcttc tatcagtgaa
1021 ctcaaacatg cactttctgg acatgccaaa gtaaagccct ttgatcccaa gattacctgc
1081 aaacaggaat gtcttatcac aacttttcaa gatgtctact ttgtatctga aagttttgaa
1141 gatgcaaagg agaagatgag agaatttacc aaaacaatta agcgtccatt tggagtgaag
1201 tataatccat atacacggag tattcagatc ctgaaagaca ccaagagcat aaccagtgcc
1261 atgaatgagc tgcagcatga tctcgatgtt gtcagtgatg cccttgctaa ggtcagcagg
1321 aagccgagta tctaaa
//