LOCUS BC104967 1630 bp mRNA linear HUM 21-JUL-2006
DEFINITION Homo sapiens tyrosine hydroxylase, mRNA (cDNA clone MGC:132627
IMAGE:8143970), complete cds.
ACCESSION BC104967
VERSION BC104967.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1630)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1630)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (13-SEP-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 3 Row: i Column: 24.
FEATURES Location/Qualifiers
source 1..1630
/db_xref="H-InvDB:HIT000338055"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:132627 IMAGE:8143970"
/tissue_type="Brain, cerebral cortex and lung, PCR rescued
clones"
/clone_lib="NIH_MGC_323"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: CACTACAT"
gene 1..1630
/gene="TH"
/gene_synonym="TYH"
/db_xref="GeneID:7054"
/db_xref="HGNC:HGNC:11782"
/db_xref="MIM:191290"
CDS 92..1585
/gene="TH"
/gene_synonym="TYH"
/codon_start=1
/product="tyrosine hydroxylase"
/protein_id="AAI04968.1"
/db_xref="GeneID:7054"
/db_xref="HGNC:HGNC:11782"
/db_xref="MIM:191290"
/translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIED
ARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKPSALSRAVKV
FETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAG
PKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDP
IPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVS
RFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLG
HVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGL
LSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASR
IQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG"
BASE COUNT 279 a 545 c 527 g 279 t
ORIGIN
1 ggacccagag ggggctttga cgtcagctca gcttataaga ggctgctggg ccagggctgt
61 ggagacggag cccggacctc cacactgagc catgcccacc cccgacgcca ccacgccaca
121 ggccaagggc ttccgcaggg ccgtgtctga gctggacgcc aagcaggcag aggccatcat
181 gtccccgcgg ttcattgggc gcaggcagag cctcatcgag gacgcccgca aggagcggga
241 ggcggcggtg gcagcagcgg ccgctgcagt cccctcggag cccggggacc ccctggaggc
301 tgtggccttt gaggagaagg aggggaaggc catgctaaac ctgctcttct ccccgagggc
361 caccaagccc tcggcgctgt cccgagctgt gaaggtgttt gagacgtttg aagccaaaat
421 ccaccatcta gagacccggc ccgcccagag gccgcgagct gggggccccc acctggagta
481 cttcgtgcgc ctcgaggtgc gccgagggga cctggccgcc ctgctcagtg gtgtgcgcca
541 ggtgtcagag gacgtgcgca gccccgcggg gcccaaggtc ccctggttcc caagaaaagt
601 gtcagagctg gacaagtgtc atcacctggt caccaagttc gaccctgacc tggacttgga
661 ccacccgggc ttctcggacc aggtgtaccg ccagcgcagg aagctgattg ctgagatcgc
721 cttccagtac aggcacggcg acccgattcc ccgtgtggag tacaccgccg aggagattgc
781 cacctggaag gaggtctaca ccacgctgaa gggcctctac gccacgcacg cctgcgggga
841 gcacctggag gcctttgctt tgctggagcg cttcagcggc taccgggaag acaatatccc
901 ccagctggag gacgtctccc gcttcctgaa ggagcgcacg ggcttccagc tgcggcctgt
961 ggccggcctg ctgtccgccc gggacttcct ggccagcctg gccttccgcg tgttccagtg
1021 cacccagtat atccgccacg cgtcctcgcc catgcactcc cctgagccgg actgctgcca
1081 cgagctgctg gggcacgtgc ccatgctggc cgaccgcacc ttcgcgcagt tctcgcagga
1141 cattggcctg gcgtccctgg gggcctcgga tgaggaaatt gagaagctgt ccacgctgta
1201 ctggttcacg gtggagttcg ggctgtgtaa gcagaacggg gaggtgaagg cctatggtgc
1261 cgggctgctg tcctcctacg gggagctcct gcactgcctg tctgaggagc ctgagattcg
1321 ggccttcgac cctgaggctg cggccgtgca gccctaccaa gaccagacgt accagtcagt
1381 ctacttcgtg tctgagagct tcagtgacgc caaggacaag ctcaggagct atgcctcacg
1441 catccagcgc cccttctccg tgaagttcga cccgtacacg ctggccatcg acgtgctgga
1501 cagcccccag gccgtgcggc gctccctgga gggtgtccag gatgagctgg acacccttgc
1561 ccatgcgctg agtgccattg gctaggtgca cggcgtccct gagggccctt cccaacctcc
1621 cctggtcctg
//