LOCUS BC101289 1448 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens T cell immunoreceptor with Ig and ITIM domains, mRNA
(cDNA clone MGC:120350 IMAGE:40024494), complete cds.
ACCESSION BC101289
VERSION BC101289.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1448)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1448)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 6 Row: m Column: 20.
FEATURES Location/Qualifiers
source 1..1448
/db_xref="H-InvDB:HIT000336687"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:120350 IMAGE:40024494"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_282"
/note="Vector: pCR-Blunt II-TOPO; Clone identification
sequence tag: CATATT sequenced from the reverse primer"
gene 1..1448
/gene="TIGIT"
/db_xref="GeneID:201633"
/db_xref="HGNC:HGNC:26838"
CDS 34..768
/gene="TIGIT"
/codon_start=1
/product="T cell immunoreceptor with Ig and ITIM domains"
/protein_id="AAI01290.1"
/db_xref="GeneID:201633"
/db_xref="HGNC:HGNC:26838"
/translation="MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQ
CHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVND
TGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVV
VALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGED
CAELHDYFNVLSYRSLGNCSFFTETG"
BASE COUNT 348 a 334 c 392 g 374 t
ORIGIN
1 catctgcttc ctgtaggccc tctgggcaga agcatgcgct ggtgtctcct cctgatctgg
61 gcccaggggc tgaggcaggc tcccctcgcc tcaggaatga tgacaggcac aatagaaaca
121 acggggaaca tttctgcaga gaaaggtggc tctatcatct tacaatgtca cctctcctcc
181 accacggcac aagtgaccca ggtcaactgg gagcagcagg accagcttct ggccatttgt
241 aatgctgact tggggtggca catctcccca tccttcaagg atcgagtggc cccaggtccc
301 ggcctgggcc tcaccctcca gtcgctgacc gtgaacgata caggggagta cttctgcatc
361 tatcacacct accctgatgg gacgtacact gggagaatct tcctggaggt cctagaaagc
421 tcagtggctg agcacggtgc caggttccag attccattgc ttggagccat ggccgcgacg
481 ctggtggtca tctgcacagc agtcatcgtg gtggtcgcgt tgactagaaa gaagaaagcc
541 ctcagaatcc attctgtgga aggtgacctc aggagaaaat cagctggaca ggaggaatgg
601 agccccagtg ctccctcacc cccaggaagc tgtgtccagg cagaagctgc acctgctggg
661 ctctgtggag agcagcgggg agaggactgt gccgagctgc atgactactt caatgtcctg
721 agttacagaa gcctgggtaa ctgcagcttc ttcacagaga ctggttagca accagaggca
781 tcttctggaa gatacacttt tgtctttgct attatagatg aatatataag cagctgtact
841 ctccatcagt gctgcgtgtg tgtgtgtgtg tgtatgtgtg tgtgtgttca gttgagtgaa
901 taaatgtcat cctcttctcc atcttcattt ccttggcctt ttcgttctat tccattttgc
961 attatggcag gcctagggtg agtaacgtgg atcttgatca taaatgcaaa attaaaaaat
1021 atcttgacct ggttttaaat ctggcagttt gagcagatcc tatgtctctg agagacacat
1081 tcctcataat ggccagcatt ttgggctaca aggttttgtg gttgatgatg aggatggcat
1141 gactgcagag ccatcctcat ctcatttttt cacgtcattt tcagtaactt tcactcattc
1201 aaaggcaggt tataagtaag tcctggtagc agcctctatg gggagatttg agagtgacta
1261 aatcttggta tctgccctca agaacttaca gttaaatggg gagacaatgt tgtcatgaaa
1321 aggtattata gtaaggagag aaggagacat acacaggcct tcaggaagag acgacagttt
1381 ggggtgaggt agttggcata ggcttatctg tgatgaagtg gcctgggagc accaagggga
1441 tgttgagg
//