LOCUS BC101074 3500 bp mRNA linear HUM 04-OCT-2006
DEFINITION Homo sapiens toll-like receptor 8, mRNA (cDNA clone MGC:119598
IMAGE:40008787), complete cds.
ACCESSION BC101074
VERSION BC101074.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3500)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3500)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Baylor Human Genome Sequencing Center
cDNA Library Preparation: Baylor Human Genome Sequencing Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAM Plate: 5 Row: i Column: 21.
FEATURES Location/Qualifiers
source 1..3500
/db_xref="H-InvDB:HIT000336484"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:119598 IMAGE:40008787"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_282"
/note="Vector: pCR-Blunt II-TOPO; Clone identification
sequence tag: AATCTCAC sequenced from the reverse primer"
gene 1..3500
/gene="TLR8"
/db_xref="GeneID:51311"
/db_xref="HGNC:HGNC:15632"
/db_xref="MIM:300366"
CDS 55..3180
/gene="TLR8"
/codon_start=1
/product="toll-like receptor 8"
/protein_id="AAI01075.1"
/db_xref="GeneID:51311"
/db_xref="HGNC:HGNC:15632"
/db_xref="MIM:300366"
/translation="MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDS
VIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH
QNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYN
ITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPP
KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASI
NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT
MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQ
LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH
IRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA
CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSH
YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW
NDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWT
LLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKH
LDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRL
VDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV
WFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELCYHLEESRDKNVL
LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENM
DVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRY
NNMYVDSIKQY"
BASE COUNT 1067 a 742 c 654 g 1037 t
ORIGIN
1 gtaccattct gcgctgctgc aagttacgga atgaaaaatt agaacaacag aaacatggaa
61 aacatgttcc ttcagtcgtc aatgctgacc tgcattttcc tgctaatatc tggttcctgt
121 gagttatgcg ccgaagaaaa tttttctaga agctatcctt gtgatgagaa aaagcaaaat
181 gactcagtta ttgcagagtg cagcaatcgt cgactacagg aagttcccca aacggtgggc
241 aaatatgtga cagaactaga cctgtctgat aatttcatca cacacataac gaatgaatca
301 tttcaagggc tgcaaaatct cactaaaata aatctaaacc acaaccccaa tgtacagcac
361 cagaacggaa atcccggtat acaatcaaat ggcttgaata tcacagacgg ggcattcctc
421 aacctaaaaa acctaaggga gttactgctt gaagacaacc agttacccca aataccctct
481 ggtttgccag agtctttgac agaacttagt ctaattcaaa acaatatata caacataact
541 aaagagggca tttcaagact tataaacttg aaaaatctct atttggcctg gaactgctat
601 tttaacaaag tttgcgagaa aactaacata gaagatggag tatttgaaac gctgacaaat
661 ttggagttgc tatcactatc tttcaattct ctttcacatg tgccacccaa actgccaagc
721 tccctacgca aactttttct gagcaacacc cagatcaaat acattagtga agaagatttc
781 aagggattga taaatttaac attactagat ttaagcggga actgtccgag gtgcttcaat
841 gccccatttc catgcgtgcc ttgtgatggt ggtgcttcaa ttaatataga tcgttttgct
901 tttcaaaact tgacccaact tcgataccta aacctctcta gcacttccct caggaagatt
961 aatgctgcct ggtttaaaaa tatgcctcat ctgaaggtgc tggatcttga attcaactat
1021 ttagtgggag aaatagcctc tggggcattt ttaacgatgc tgccccgctt agaaatactt
1081 gacttgtctt ttaactatat aaaggggagt tatccacagc atattaatat ttccagaaac
1141 ttctctaaac ttttgtctct acgggcattg catttaagag gttatgtgtt ccaggaactc
1201 agagaagatg atttccagcc cctgatgcag cttccaaact tatcgactat caacttgggt
1261 attaatttta ttaagcaaat cgatttcaaa cttttccaaa atttctccaa tctggaaatt
1321 atttacttgt cagaaaacag aatatcaccg ttggtaaaag atacccggca gagttatgca
1381 aatagttcct cttttcaacg tcatatccgg aaacgacgct caacagattt tgagtttgac
1441 ccacattcga acttttatca tttcacccgt cctttaataa agccacaatg tgctgcttat
1501 ggaaaagcct tagatttaag cctcaacagt attttcttca ttgggccaaa ccaatttgaa
1561 aatcttcctg acattgcctg tttaaatctg tctgcaaata gcaatgctca agtgttaagt
1621 ggaactgaat tttcagccat tcctcatgtc aaatatttgg atttgacaaa caatagacta
1681 gactttgata atgctagtgc tcttactgaa ttgtccgact tggaagttct agatctcagc
1741 tataattcac actatttcag aatagcaggc gtaacacatc atctagaatt tattcaaaat
1801 ttcacaaatc taaaagtttt aaacttgagc cacaacaaca tttatacttt aacagataag
1861 tataacctgg aaagcaagtc cctggtagaa ttagttttca gtggcaatcg ccttgacatt
1921 ttgtggaatg atgatgacaa caggtatatc tccattttca aaggtctcaa gaatctgaca
1981 cgtctggatt tatcccttaa taggctcaag cacatcccaa atgaagcatt ccttaatttg
2041 ccagcgagtc tcactgaact acatataaat gataatatgt taaagttttt taactggaca
2101 ttactccagc agtttcctcg tctcgagttg cttgacttac gtggaaacaa actactcttt
2161 ttaactgata gcctatctga ctttacatct tcccttcgga cactgctgct gagtcataac
2221 aggatttccc acctaccctc tggctttctt tctgaagtca gtagtctgaa gcacctcgat
2281 ttaagttcca atctgctaaa aacaataaac aaatccgcac ttgaaactaa gaccaccacc
2341 aaattatcta tgttggaact acacggaaac ccctttgaat gcacctgtga cattggagat
2401 ttccgaagat ggatggatga acatctgaat gtcaaaattc ccagactggt agatgtcatt
2461 tgtgccagtc ctggggatca aagagggaag agtattgtga gtctggagct aacaacttgt
2521 gtttcagatg tcactgcagt gatattattt ttcttcacgt tctttatcac caccatggtt
2581 atgttggctg ccctggctca ccatttgttt tactgggatg tttggtttat atataatgtg
2641 tgtttagcta aggtaaaagg ctacaggtct ctttccacat cccaaacttt ctatgatgct
2701 tacatttctt atgacaccaa agatgcctct gttactgact gggtgataaa tgagctgtgc
2761 taccaccttg aagagagccg agacaaaaac gttctccttt gtctagagga gagggattgg
2821 gacccgggat tggccatcat cgacaacctc atgcagagca tcaaccaaag caagaaaaca
2881 gtatttgttt taaccaaaaa atatgcaaaa agctggaact ttaaaacagc tttttacttg
2941 gctttgcaga ggctaatgga tgagaacatg gatgtgatta tatttatcct gctggagcca
3001 gtgttacagc attctcagta tttgaggcta cggcagcgga tctgtaagag ctccatcctc
3061 cagtggcctg acaacccgaa ggcagaaggc ttgttttggc aaactctgag aaatgtggtc
3121 ttgactgaaa atgattcacg gtataacaat atgtatgtcg attccattaa gcaatactaa
3181 ctgacgttaa gtcatgattt cgcgccataa taaagatgca aaggaatgac atttctgtat
3241 tagttatcta ttgctatgta acaaattatc ccaaaactta gtggtttaaa acaacacatt
3301 tgctggccca cagtttttga gggtcaggag tccaggccca gcataactgg gtcctctgct
3361 cagggtgtct cagaggctgc aatgtaggtg ttcaccagag acataggcat cactggggtc
3421 acactcatgt ggttgttttc tggattcaat tcctcctgcg ctattggcca aaggctatac
3481 tcatgtaagc catgcgagcc
//