LOCUS       BC095428                1439 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1,
            mRNA (cDNA clone MGC:110965 IMAGE:30709297), complete cds.
ACCESSION   BC095428
VERSION     BC095428.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1439)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 1439)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2005) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Thompson Lab, University of WI
            cDNA Library Preparation: Chris Bradfield
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 220 Row: a Column: 1
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 18375504.
FEATURES             Location/Qualifiers
     source          1..1439
                     /db_xref="H-InvDB:HIT000335221"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:110965 IMAGE:30709297"
                     /tissue_type="Embryonic Stem Cells, WA07 (H7) ES cell
                     line, passage 22, 500-2Kb average insert size"
                     /clone_lib="NIH_MGC_239"
                     /lab_host="DH10B"
                     /note="Vector: pCI-neo"
     gene            1..1439
                     /gene="APEX1"
                     /gene_synonym="APE"
                     /gene_synonym="APE1"
                     /gene_synonym="APEN"
                     /gene_synonym="APX"
                     /gene_synonym="HAP1"
                     /gene_synonym="REF-1"
                     /gene_synonym="REF1"
                     /db_xref="GeneID:328"
                     /db_xref="HGNC:HGNC:587"
                     /db_xref="MIM:107748"
     CDS             207..1163
                     /gene="APEX1"
                     /gene_synonym="APE"
                     /gene_synonym="APE1"
                     /gene_synonym="APEN"
                     /gene_synonym="APX"
                     /gene_synonym="HAP1"
                     /gene_synonym="REF-1"
                     /gene_synonym="REF1"
                     /codon_start=1
                     /product="APEX nuclease (multifunctional DNA repair
                     enzyme) 1"
                     /protein_id="AAH95428.1"
                     /db_xref="GeneID:328"
                     /db_xref="HGNC:HGNC:587"
                     /db_xref="MIM:107748"
                     /translation="MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPAL
                     YEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSEN
                     KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVA
                     EFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEI
                     DLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSK
                     NVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL"
BASE COUNT          410 a          336 c          364 g          329 t
ORIGIN      
        1 aaaaaaaaaa agaaaaaaaa aaaaacttct ttgtgctcgg gttaggagga gctaggctgc
       61 catcgggccg gtgcagatac ggggttgctc ttttgctcat aagaggggct tcgctggcag
      121 tctgaacggc aagcttgagc aacgcggtaa aaatattgct tcggtgggtg acgcggtaca
      181 gctgcccaag ggcgttcgta acgggaatgc cgaagcgtgg gaaaaaggga gcggtggcgg
      241 aagacgggga tgagctcagg acagagccag aggccaagaa gagtaagacg gccgcaaaga
      301 aaaatgacaa agaggcagca ggagagggcc cagccctgta tgaggacccc ccagatcaga
      361 aaacctcacc cagtggcaaa cctgccacac tcaagatctg ctcttggaat gtggatgggc
      421 ttcgagcctg gattaagaag aaaggattag attgggtaaa ggaagaagcc ccagatatac
      481 tgtgccttca agagaccaaa tgttcagaga acaaactacc agctgaactt caggagctgc
      541 ctggactctc tcatcaatac tggtcagctc cttcggacaa ggaagggtac agtggcgtgg
      601 gcctgctttc ccgccagtgc ccactcaaag tttcttacgg cataggcgat gaggagcatg
      661 atcaggaagg ccgggtgatt gtggctgaat ttgactcgtt tgtgctggta acagcatatg
      721 tacctaatgc aggccgaggt ctggtacgac tggagtaccg gcagcgctgg gatgaagcct
      781 ttcgcaagtt cctgaagggc ctggcttccc gaaagcccct tgtgctgtgt ggagacctca
      841 atgtggcaca tgaagaaatt gaccttcgca accccaaggg gaacaaaaag aatgctggct
      901 tcacgccaca agagcgccaa ggcttcgggg aattactgca ggctgtgcca ctggctgaca
      961 gctttaggca cctctacccc aacacaccct atgcctacac cttttggact tatatgatga
     1021 atgctcgatc caagaatgtt ggttggcgcc ttgattactt tttgttgtcc cactctctgt
     1081 tacctgcatt gtgtgacagc aagatccgtt ccaaggccct cggcagtgat cactgtccta
     1141 tcaccctata cctagcactg tgacaccacc cctaaatcac tttgagcctg ggaaataagc
     1201 cccctcaact accattcctt ctttaaacac tcttcagaga aatctgcatt ctatttctca
     1261 tgtataaaac taggaatcct ccaaccaggc tcctgtgata gagttctttt aagcccaaga
     1321 ttttttattt gagggttttt tgttttttaa aaaaaaattg aacaaagact actaatgact
     1381 ttgtttgaat tatccacatg aaaataaaga gccatagttt cagaaaaaaa aaaaaaaaa
//