LOCUS       BC092517                5246 bp    mRNA    linear   HUM 19-MAR-2009
DEFINITION  Homo sapiens DNA (cytosine-5-)-methyltransferase 1, mRNA (cDNA
            clone MGC:104992 IMAGE:3077831), complete cds.
ACCESSION   BC092517
VERSION     BC092517.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5246)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 5246)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-APR-2005) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Louis M. Staudt, M.D., Ph.D.
            cDNA Library Preparation: M. Bento Soares, University of Iowa
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 199 Row: c Column: 19
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 4503350
            The stop codon of the CDS annotated on this record is located > 55
            bases upstream of a splice junction, and therefore the mRNA is
            predicted to be subject to nonsense-mediated mRNA decay (NMD).
FEATURES             Location/Qualifiers
     source          1..5246
                     /db_xref="H-InvDB:HIT000334491"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:104992 IMAGE:3077831"
                     /tissue_type="Lymph, normal germinal center B cells"
                     /clone_lib="NIH_MGC_50"
                     /lab_host="DH10B"
                     /note="Vector: pT7T3-Pac"
     gene            1..5246
                     /gene="DNMT1"
                     /gene_synonym="AIM"
                     /gene_synonym="CXXC9"
                     /gene_synonym="MCMT"
                     /db_xref="GeneID:1786"
                     /db_xref="HGNC:HGNC:2976"
                     /db_xref="MIM:126375"
     CDS             359..4894
                     /gene="DNMT1"
                     /gene_synonym="AIM"
                     /gene_synonym="CXXC9"
                     /gene_synonym="MCMT"
                     /codon_start=1
                     /product="DNMT1 protein"
                     /protein_id="AAH92517.1"
                     /db_xref="GeneID:1786"
                     /db_xref="HGNC:HGNC:2976"
                     /db_xref="MIM:126375"
                     /translation="MADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRA
                     EPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRV
                     TSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDRE
                     ARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEK
                     RRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQML
                     TNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSA
                     KPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAP
                     IFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQ
                     FVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDR
                     GPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACK
                     DMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKN
                     RISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSS
                     NGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAM
                     EGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMR
                     QKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRK
                     EPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVN
                     KFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSM
                     GGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIK
                     LPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNI
                     LLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSF
                     LSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQT
                     RRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITV
                     RDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARM
                     RHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGK
                     ACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLH
                     PEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAK
                     ARESASAKIKEEEAAKD"
BASE COUNT         1405 a         1416 c         1452 g          973 t
ORIGIN      
        1 gcgctgccgc cgccgcgtct gctgaagcct ccgagatgcc ggcgcgtacc gccccagccc
       61 gggtgcccac actggccgtc ccggccatct cgctgcccga cgatgtccgc aggcggctca
      121 aagatttgga aagagacagc ttaacagaaa aggaatgtgt gaaggagaaa ttgaatctct
      181 tgcacgaatt tctgcaaaca gaaataaaga atcagttatg tgacttggaa accaaattac
      241 gtaaagaaga attatccgag atttgtcctt ggagaacggt gctcatgctt acaaccggga
      301 agtgaatgga cgtctagaaa acgggaacca agcaagaagt gaagcccgta gagtgggaat
      361 ggcagatgcc aacagccccc ccaaacccct ttccaaacct cgcacgccca ggaggagcaa
      421 gtccgatgga gaggctaagc gttcaagaga ccctcctgcc tcagcctccc aagtaactgg
      481 gattagagct gaaccttcac ctagccccag gattacaagg aaaagcacca ggcaaaccac
      541 catcacatct cattttgcaa agggccctgc caaacggaaa cctcaggaag agtctgaaag
      601 agccaaatcg gatgagtcca tcaaggaaga agacaaagac caggatgaga agagacgtag
      661 agttacatcc agagaacgag ttgctagacc gcttcctgca gaagaacctg aaagagcaaa
      721 atcaggaacg cgcactgaaa aggaagaaga aagagatgaa aaagaagaaa agagactccg
      781 aagtcaaacc aaagaaccaa cacccaaaca gaaactgaag gaggagccgg acagagaagc
      841 cagggcaggc gtgcaggctg acgaggacga agatggagac gagaaagatg agaagaagca
      901 cagaagtcaa cccaaagatc tagctgccaa acggaggccc gaagaaaaag aacctgaaaa
      961 agtaaatcca cagatttctg atgaaaaaga cgaggatgaa aaggaggaga agagacgcaa
     1021 aacgaccccc aaagaaccaa cggagaaaaa aatggctcgc gccaaaacag tcatgaactc
     1081 caagacccac cctcccaagt gcattcagtg cgggcagtac ctggacgacc ctgacctcaa
     1141 atatgggcag cacccaccag acgcggtgga tgagccacag atgctgacaa atgagaagct
     1201 gtccatcttt gatgccaacg agtctggctt tgagagttat gaggcgcttc cccagcacaa
     1261 actgacctgc ttcagtgtgt actgtaagca cggtcacctg tgtcccatcg acaccggcct
     1321 catcgagaag aatatcgaac tcttcttttc tggttcagca aaaccaatct atgatgatga
     1381 cccatctctt gaaggtggtg ttaatggcaa aaatcttggc cccataaatg aatggtggat
     1441 cactggcttt gatggaggtg aaaaggccct catcggcttc agcacctcat ttgccgaata
     1501 cattctgatg gatcccagtc ccgagtatgc gcccatattt gggctgatgc aggagaagat
     1561 ctacatcagc aagattgtgg tggagttcct gcagagcaat tccgactcga cctatgagga
     1621 cctgatcaac aagatcgaga ccacggttcc tccttctggc ctcaacttga accgcttcac
     1681 agaggactcc ctcctgcgac acgcgcagtt tgtggtggag caggtggaga gttatgacga
     1741 ggccggggac agtgatgagc agcccatctt cctgacgccc tgcatgcggg acctgatcaa
     1801 gctggctggg gtcacgctgg gacagaggcg agcccaggcg aggcggcaga ccatcaggca
     1861 ttctaccagg gagaaggaca ggggacccac gaaagccacc accaccaagc tggtctacca
     1921 gatcttcgat actttcttcg cagagcaaat tgaaaaggat gacagagaag acaaggagaa
     1981 cgcctttaag cgccggcgat gtggcgtctg tgaggtgtgt cagcagcctg agtgtgggaa
     2041 atgtaaagcc tgcaaggaca tggttaaatt tggtggcagt ggacggagca agcaggcttg
     2101 ccaagagcgg aggtgtccca atatggccat gaaggaggca gatgacgatg aggaagtcga
     2161 tgataacatc ccagagatgc cgtcacccaa aaaaatgcac caggggaaga agaagaaaca
     2221 gaacaagaat cgcatctctt gggtcggaga agccgtcaag actgatggga agaagagtta
     2281 ctataagaag gtgtgcattg atgcggaaac cctggaagtg ggggactgtg tctctgttat
     2341 tccagatgat tcctcaaaac cgctgtatct agcaagggtc acggcgctgt gggaggacag
     2401 cagcaacggg cagatgtttc acgcccactg gttctgcgct gggacagaca cagtcctcgg
     2461 ggccacgtcg gaccctctgg agctgttctt ggtggatgaa tgtgaggaca tgcagctttc
     2521 atatatccac agcaaagtga aagtcatcta caaagccccc tccgaaaact gggccatgga
     2581 gggaggcatg gatcccgagt ccctgctgga gggggacgac gggaagacct acttctacca
     2641 gctgtggtat gatcaagact acgcgagatt cgagtcccct ccaaaaaccc agccaacaga
     2701 ggacaacaag ttcaaattct gtgtgagctg tgcccgtctg gctgagatga ggcaaaaaga
     2761 aatccccagg gtcctggagc agctcgagga cctggatagc cgggtcctct actactcagc
     2821 caccaagaac ggcatcctgt accgagttgg tgatggtgtg tacctgcccc ctgaggcctt
     2881 cacgttcaac atcaagctgt ccagtcccgt gaaacgccca cggaaggagc ccgtggatga
     2941 ggacctgtac ccagagcact accggaaata ctccgactac atcaaaggca gcaacctgga
     3001 tgcccctgag ccctaccgaa ttggccggat caaagagatc ttctgtccca agaagagcaa
     3061 cggcaggccc aatgagactg acatcaaaat ccgggtcaac aagttctaca ggcctgagaa
     3121 cacccacaag tccactccag cgagctacca cgcagacatc aacctgctct actggagcga
     3181 cgaggaggcc gtggtggact tcaaggctgt gcagggccgc tgcaccgtgg agtatgggga
     3241 ggacctgccc gagtgcgtcc aggtgtactc catgggcggc cccaaccgct tctacttcct
     3301 cgaggcctat aatgcaaaga gcaaaagctt tgaagatcct cccaaccatg cccgtagccc
     3361 tggaaacaaa gggaagggca agggaaaagg gaagggcaag cccaagtccc aagcctgtga
     3421 gccgagcgag ccagagatag agatcaagct gcccaagctg cggaccctgg atgtgttttc
     3481 tggctgcggg gggttgtcgg agggattcca ccaagcaggc atctctgaca cgctgtgggc
     3541 catcgagatg tgggaccctg cggcccaggc gttccggctg aacaaccccg gctccacagt
     3601 gttcacagag gactgcaaca tcctgctgaa gctggtcatg gctggggaga ccaccaactc
     3661 ccgcggccag cggctgcccc agaagggaga cgtggagatg ctgtgcggcg ggccgccctg
     3721 ccagggcttc agcggcatga accgcttcaa ttcgcgcacc tactccaagt tcaaaaactc
     3781 tctggtggtt tccttcctca gctactgcga ctactaccgg ccccggttct tcctcctgga
     3841 gaatgtcagg aactttgtct ccttcaagcg ctccatggtc ctgaagctca ccctccgctg
     3901 cctggtccgc atgggctatc agtgcacctt cggcgtgctg caggccggtc agtacggcgt
     3961 ggcccagact aggaggcggg ccatcatcct ggccgcggcc cctggagaga agctccctct
     4021 gttcccggag ccactgcacg tgtttgctcc ccgggcctgc cagctgagcg tggtggtgga
     4081 tgacaagaag tttgtgagca acataaccag gttgagctcg ggtcctttcc ggaccatcac
     4141 ggtgcgagac acgatgtccg acctgccgga ggtgcggaat ggagcctcgg cactggagat
     4201 ctcctacaac ggggagcctc agtcctggtt ccagaggcag ctccggggcg cacagtacca
     4261 gcccatcctc agggaccaca tctgtaagga catgagtgca ttggtggctg cccgcatgcg
     4321 gcacatcccc ttggccccag ggtcagactg gcgcgatctg cccaacatcg aggtgcggct
     4381 ctcagacggc accatggcca ggaagctgcg gtatacccac catgacagga agaacggccg
     4441 cagcagctct ggggccctcc gtggggtctg ctcctgcgtg gaagccggca aagcctgcga
     4501 ccccgcagcc aggcagttca acaccctcat cccctggtgc ctgccccaca ccgggaaccg
     4561 gcacaaccac tgggctggcc tctatggaag gctcgagtgg gacggcttct tcagcacaac
     4621 cgtcaccaac cccgagccca tgggcaagca gggccgcgtg ctccacccag agcagcaccg
     4681 tgtggtgagc gtgcgggagt gtgcccgctc ccagggcttc cctgacacct accggctctt
     4741 cggcaacatc ctggacaagc accggcaggt gggcaatgcc gtgccaccgc ccctggccaa
     4801 agccattggc ttggagatca agctttgtat gttggccaaa gcccgagaga gtgcctcagc
     4861 taaaataaag gaggaggaag ctgctaagga ctagttctgc cctcccgtca cccctgtttc
     4921 tggcaccagg aatccccaac atgcactgat gttgtgtttt taacatgtca atctgtccgt
     4981 tcacatgtgt ggtacatggt gtttgtggcc ttggctgaca tgaagctgtt gtgtgaggtt
     5041 cgcttatcaa ctaatgattt agtgatcaaa ttgtgcagta ctttgtgcat tctggatttt
     5101 aaaagttttt tattatgcat tatatcaaat ctaccactgt atgagtggaa attaagactt
     5161 tatgtagttt ttatatgttg taatatttct tcaaataaat ctctcctata aaccaaaaaa
     5221 aaaaaaaaaa aaaaaaaaaa aaaaaa
//