LOCUS BC089410 3217 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens interleukin 6 receptor, mRNA (cDNA clone MGC:104991
IMAGE:3078506), complete cds.
ACCESSION BC089410
VERSION BC089410.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3217)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3217)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-FEB-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Louis M. Staudt, M.D., Ph.D.
cDNA Library Preparation: M. Bento Soares, University of Iowa
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 199 Row: c Column: 24
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 31317248.
FEATURES Location/Qualifiers
source 1..3217
/db_xref="H-InvDB:HIT000266253"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:104991 IMAGE:3078506"
/tissue_type="Lymph, normal germinal center B cells"
/clone_lib="NIH_MGC_50"
/lab_host="DH10B"
/note="Vector: pT7T3-Pac"
gene 1..3217
/gene="IL6R"
/gene_synonym="CD126"
/gene_synonym="IL-6R-1"
/gene_synonym="IL-6R-alpha"
/gene_synonym="IL6RA"
/db_xref="GeneID:3570"
/db_xref="HGNC:HGNC:6019"
/db_xref="MIM:147880"
CDS 408..1505
/gene="IL6R"
/gene_synonym="CD126"
/gene_synonym="IL-6R-1"
/gene_synonym="IL-6R-alpha"
/gene_synonym="IL6RA"
/codon_start=1
/product="interleukin 6 receptor"
/protein_id="AAH89410.1"
/db_xref="GeneID:3570"
/db_xref="HGNC:HGNC:6019"
/db_xref="MIM:147880"
/translation="MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVT
LTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRP
AGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAED
FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDP
PANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHH
CVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQAL
TTNKDDDNILFRDSANATSLPGSRRRGSCGL"
BASE COUNT 743 a 891 c 929 g 654 t
ORIGIN
1 ggcgctgtgg caggaagcca ccccctcggt cggccggtgc gcggggctgt tgcgccatcc
61 gctccggctt tcgtaaccgc accctgggac ggcccagaga cgctccagcg cgagttcctc
121 aaatgttttc ctgcgttgcc aggaccgtcc gccgctctga gtcatgtgcg agtgggaagt
181 cgcactgaca ctgagccggg ccagagggag aggagccgag cgcggcgcgg ggccgaggga
241 ctcgcagtgt gtgtagagag ccgggctcct gcggatgggg gctgcccccg gggcctgagc
301 ccgcctgccc gcccaccgcc ccgccccgcc cctgccaccc ctgccgcccg gttcccatta
361 gcctgtccgc ctctgcggga ccatggagtg gtagccgagg aggaagcatg ctggccgtcg
421 gctgcgcgct gctggctgcc ctgctggccg cgccgggagc ggcgctggcc ccaaggcgct
481 gccctgcgca ggaggtggcg agaggcgtgc tgaccagtct gccaggagac agcgtgactc
541 tgacctgccc gggggtagag ccggaagaca atgccactgt tcactgggtg ctcaggaagc
601 cggctgcagg ctcccacccc agcagatggg ctggcatggg aaggaggctg ctgctgaggt
661 cggtgcagct ccacgactct ggaaactatt catgctaccg ggccggccgc ccagctggga
721 ctgtgcactt gctggtggat gttccccccg aggagcccca gctctcctgc ttccggaaga
781 gccccctcag caatgttgtt tgtgagtggg gtcctcggag caccccatcc ctgacgacaa
841 aggctgtgct cttggtgagg aagtttcaga acagtccggc cgaagacttc caggagccgt
901 gccagtattc ccaggagtcc cagaagttct cctgccagtt agcagtcccg gagggagaca
961 gctctttcta catagtgtcc atgtgcgtcg ccagtagtgt cgggagcaag ttcagcaaaa
1021 ctcaaacctt tcagggttgt ggaatcttgc agcctgatcc gcctgccaac atcacagtca
1081 ctgccgtggc cagaaacccc cgctggctca gtgtcacctg gcaagacccc cactcctgga
1141 actcatcttt ctacagacta cggtttgagc tcagatatcg ggctgaacgg tcaaagacat
1201 tcacaacatg gatggtcaag gacctccagc atcactgtgt catccacgac gcctggagcg
1261 gcctgaggca cgtggtgcag cttcgtgccc aggaggagtt cgggcaaggc gagtggagcg
1321 agtggagccc ggaggccatg ggcacgcctt ggacagaatc caggagtcct ccagctgaga
1381 acgaggtgtc cacccccatg caggcactta ctactaataa agacgatgat aatattctct
1441 tcagagattc tgcaaatgcg acaagcctcc caggttcaag aagacgtgga agctgcgggc
1501 tctgaaggaa ggcaagacaa gcatgcatcc gccgtactct ttggggcagc tggtcccgga
1561 gaggcctcga cccaccccag tgcttgttcc tctcatctcc ccaccggtgt cccccagcag
1621 cctggggtct gacaatacct cgagccacaa ccgaccagat gccagggacc cacggagccc
1681 ttatgacatc agcaatacag actacttctt ccccagatag ctggctgggt ggcaccagca
1741 gcctggaccc tgtggatgat aaaacacaaa cgggctcagc aaaagatgct tctcactgcc
1801 atgccagctt atctcagggg tgtgcggcct ttggcttcac ggaagagcct tgcggaaggt
1861 tctacgccag gggaaaatca gcctgctcca gctgttcagc tggttgaggt ttcaaacctc
1921 cctttccaaa tgcccagctt aaaggggcta gagtgaactt gggccactgt gaagagaacc
1981 atatcaagac tctttggaca ctcacacgga cactcaaaag ctgggcaggt tggtgggggc
2041 ctcggtgtgg agaagcggct ggcagcccac ccctcaacac ctctgcacaa gctgcaccct
2101 caggcaggtg ggatggattt ccagccaaag cctcctccag ccgccatgct cctggcccac
2161 tgcatcgttt catcttccaa ctcaaactct taaaacccaa gtgccttagc aaattctgtt
2221 tttctaggcc tggggacggc ttttacttaa accgccaagg ctgggggaag aagctctctc
2281 ctccctttct tccctacagt tgaaaaacag ctgagggtga gtgggtgaat aatacagtat
2341 ctcagggcct ggtcgttttc aacagaatta taattagttc ctcattagca ttttgctaaa
2401 tgtgaatgat gatcctaggc atttgctgaa tacagaggca actgcattgg ctttgggttg
2461 caggacctca ggtgagaagc agaggaagga gaggagaggg gcacagggtc tctaccatcc
2521 cctgtagagt gggagctgag tgggggatca cagcctctga aaaccaatgt tctctcttct
2581 ccacctccca caaaggagag ctagcagcag ggagggcttc tgccatttct gagatcaaaa
2641 cggttttact gcagctttgt ttgttgtcag ctgaacctgg gtaactaggg aagataatat
2701 taaggaagac aatgtgaaaa gaaaaatgag cctggcaaga atgtgtttaa acttggtttt
2761 taaaaaactg ctgactgttt tctcttgaga gggtggaata tccaatattc gctgtgtcag
2821 catagaagta acttacttag gtgtggggga agcaccataa ctttgtttag cccaaaacca
2881 agtcaagtga aaaaggagga agagaaaaaa tattttcctg ccaggcatgg tggcccacgc
2941 acttcgggag gtcgaggcag gaggatcact tgagtccaga agtttgagat cagcctgggc
3001 aatgtgataa aaccccatct ctacaaaaag cataaaaatt agccaagtgt ggtagagtgt
3061 gcctgaagtc ccagatactt ggggggctga ggtgggagga tctcttgagc ctgggaggtc
3121 aaggctgcag tgagccgaga ttgcaccact gcactccagc ctgggtgaca gagcaagtga
3181 gaccctgtct caaaaaaaaa aaaaaaaaaa aaaaaaa
//