LOCUS BC082974 4572 bp mRNA linear HUM 11-AUG-2006 DEFINITION Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 4, mRNA (cDNA clone MGC:99705 IMAGE:6291175), complete cds. ACCESSION BC082974 VERSION BC082974.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4572) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 4572) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (24-SEP-2004) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 59 Row: j Column: 11 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 70912385. FEATURES Location/Qualifiers source 1..4572 /db_xref="H-InvDB:HIT000266012" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:99705 IMAGE:6291175" /tissue_type="Eye, normal, pigmented retinal epithelium" /clone_lib="NIH_MGC_43" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..4572 /gene="PLEKHG4" /gene_synonym="DKFZP434I216" /gene_synonym="puratrophin1" /db_xref="GeneID:25894" /db_xref="HGNC:HGNC:24501" /db_xref="MIM:609526" CDS 428..3883 /gene="PLEKHG4" /gene_synonym="DKFZP434I216" /gene_synonym="puratrophin1" /codon_start=1 /product="PLEKHG4 protein" /protein_id="AAH82974.1" /db_xref="GeneID:25894" /db_xref="HGNC:HGNC:24501" /db_xref="MIM:609526" /translation="MHVKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQR GTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLS PGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGT RDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICA PSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLP TSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLL QQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVD GLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQ AQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQR CQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHF RKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVP AAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPP GSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSY GHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQS LVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLL FSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSL AIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVL KCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCP LYPSFPEEAALEAEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLE DLPCV" BASE COUNT 897 a 1373 c 1395 g 907 t ORIGIN 1 gagaggtctg gctgggagtt agggatggag caggacaact ccaaggctcc cctctggcag 61 ccagacctgc tcatgaagaa ggctcctcgg tgaggagggt gaggctcaaa gagcagagtt 121 cctggagcgc ccccagcagg cctgaattgc agttcctgtg ccctggcact aagactggca 181 cctcctgcgg cccatgccct tcgcctgcat tgcccactga gtcccactcg actgtcttca 241 gcgcggttca cactgagacc cagccctctc ccgctggccc cgagcaggcc cacctttagg 301 agggcgtgat ggaaggcccc tggagaatgg ggatgagtcc ccagactctc agggccatgc 361 caccgactgg agatttgctg tgtgcagttt cagggatgcc tgggaagagg aggaacctgc 421 ttcccagatg cacgttaagg acccaggtcc tccaagacca ccagccgggg ccacccagga 481 tgaggagcta cagggcagcc ccttgtccag gaaattccag ttacccccag ctgcagatga 541 gtcgggggat gcccagaggg gcacagtaga aagctcctca gtcctgtcag aagggccagg 601 cccctctgga gtggagagtc tcctatgccc catgtcctcc cacctcagct tggcacaggg 661 tgagagtgac accccagggg tagggttggt aggggaccca ggtccaagca gggcgatgcc 721 atctggcttg agccctgggg cattggacag cgaccctgtg ggccttggag accctttatc 781 agaaatatca aagctgctgg aggcagcccc cagtggatcc ggcctcccta agcctgctga 841 ctgcctcctg gcccaagacc tctgttggga gctgctggcc agtggtatgg ccaccttgcc 901 agggactcgg gatgtccaag gccgggcagt gctgcttctg tgtgcccaca gcccagcctg 961 gcttcagtct gagtgcagca gccaggaact catccgcctc ctgctgtacc tgcgaagcat 1021 ccccaggccc gaagtacagg cactgggact gacagtgcta gttgatgccc gaatttgtgc 1081 tccaagttct tccctcttct ctgggctcag ccaactacaa gaagcagccc caggggccgt 1141 gtaccaggtg ctgctagtgg gaagcacgct gctgaaggaa gtgccttccg ggctgcagct 1201 ggagcagttg ccttctcaga gcctgctgac ccacatccca acggcggggc tgcccacttc 1261 gctaggagga ggcctgcctt actgccacca ggcctggctg gatttccgaa ggcggctgga 1321 agctctacta cagaactgcc aggcagcttg tgccctgctc cagggggcca tcgaaagtgt 1381 gaaggctgtg ccccagccca tggagcctgg ggaggtcggt cagctgctac agcagacaga 1441 ggtcctgatg cagcaggtgc tagactcgcc atggctggca tggctacaat gccagggggg 1501 ccgggagctg acatggctga agcaagaggt cccagaggtg accctgagcc cagactacag 1561 gacggcaatg gacaaggctg acgagctata tgaccgggtg gatggattgc tgcaccaact 1621 gaccctgcag agcaaccagc gaatacaggc cctagagttg gtccaaacac tggaggcccg 1681 ggaaagcgga ctgcaccaga ttgaagtgtg gctgcagcag gtgggctggc cagcactgga 1741 ggaggctggg gagccctcgc tggacatgct gctccaggcc caaggctctt ttcaggagct 1801 gtaccaggtt gcccaggagc aggtcaggca aggggagaag tttctgcagc cgctgactgg 1861 ctgggaggcg gctgaactgg acccccctgg ggcacgcttt ctggccctgc gagcccagct 1921 gactgaattc tctagggctt tggcccagcg gtgccagcgg ctggcggatg ctgagaggct 1981 gtttcagctc ttcagggagg ccttgacgtg ggctgaggag gggcagcgag tgttggcaga 2041 gctggagcag gaacgcccgg gggttgtgtt gcagcagctg cagctgcact ggaccaggca 2101 ccctgacttg cctcctgccc acttccgaaa gatgtgggct ctggccacgg ggctgggctc 2161 agaggccatc cgccaggagt gccgctgggc ctgggcgcgg tgccaggaca cctggctggc 2221 cctggaccaa aagcttgagg cttcactgaa gctaccaccg gtgggcagca cagctagcct 2281 gtgtgtcagc caggtccccg ctgcacctgc ccaccctccc ctgaggaagg cctacagctt 2341 cgatcggaat ctggggcaga gtctcagtga acctgcctgc cactgccacc atgcggccac 2401 tattgctgcc tgccgcagac cagaggctgg aggaggtgcc ctgccccagg catcccctac 2461 tgtgcctcca ccaggcagct ctgaccccag gagcctcaac aggctacagc tggtgctggc 2521 agagatggtg gccacggagc gggagtatgt ccgggctcta gagtacacta tggagaacta 2581 tttccccgag ctggatcgcc ccgatgtgcc ccagggcctc cgcggtcagc gtgcccacct 2641 ctttggcaac ctggagaagc tgcgggactt ccactgccac ttcttcctgc gtgagctgga 2701 ggcttgcacc cggcacccac cacgagtggc ctatgccttc ctgcgccata gggtgcagtt 2761 tgggatgtac gcgctctaca gcaagaataa gcctcgctcc gatgccctga tgtcaagcta 2821 tgggcacacc ttcttcaagg acaagcagca agcactgggg gaccacctgg acctggcctc 2881 ctacctgcta aagcccatcc agcgcatggg caagtacgca ctgctgctgc aggagctggc 2941 acgggcctgc gggggcccca cgcaggagct cagtgcgctg cgggaggccc agagccttgt 3001 gcacttccag ctgcggcacg gaaacgacct gctggccatg gacgccatcc agggctgtga 3061 tgttaacctc aaggaacagg ggcagctggt gcgacaggat gagtttgtgg tgcgcactgg 3121 gcgccacaag tccgtgcgcc gcatcttcct ttttgaggag ctgctgctct tcagcaagcc 3181 tcgccatggg cccacagggg ttgacacatt tgcctacaag cgctccttca agatggcaga 3241 ccttggtctc actgagtgct gtgggaacag caacctgcgc ttcgagatct ggttccgccg 3301 ccgcaaggcc agggacacct ttgtgctgca ggcctccagc ctggctatca agcaggcctg 3361 gacagctgac atctcccacc tgctttggag gcaggccgtc cacaacaagg aggtgcgcat 3421 ggctgagatg gtgtccatgg gtgtggggaa caaggccttc cgagacattg ctcccagcga 3481 ggaagccatc aacgaccgca ccgtcaacta tgtcctgaag tgccgagaag ttcgctctcg 3541 ggcgtccatt gccgtagccc cgtttgacca tgacagcctc tacctggggg cctcgaactc 3601 ccttcctgga gaccctgcct cttgctctgt tctggggtcc ctcaacctgc acctgtacag 3661 agacccagct cttctgggtc tccgctgtcc cctgtatccc agcttcccag aggaagcagc 3721 actggaggct gaggcagagc tgggcggcca gccctctttg actgctgagg actcagagat 3781 ctcgtcccaa tgcccatcag ccagtggctc cagtggctct gacagcagct gtgtgtcagg 3841 gcaggccctg ggtaggggcc tggaggactt accctgtgtc tgagcccggg actggacgag 3901 cagtagatcc agcagcctgc agctccaagg aacattgcct ctctggatct gctgtgacca 3961 gggtgtggct gacacctggg ctacctccaa cctacatgtg caacgctgtt gactaccctt 4021 tctgatgtgt gtggccattg gactaactgg cacggggcct ctctagggaa gtctggttgt 4081 agagcctgaa taggctcctg gccccatgac cccttctcct gtccccagct cccatcccag 4141 ttgtgggtta agaataggct agagcagaca ttgggtgttt ccatgctgta ggctggtggg 4201 ggaccatgtg cctctaggca gtgactaggg tgcccccacc cctcaggaag aacacaggtg 4261 ggctcctagc agctgatccc caatgcctgg ccttaaagcc gagctcagtt accataggga 4321 caggtccacc tctactgggc cctcatgctt gcctttcctg gcccccaggc ccagcccctt 4381 tttactgggg cagtttcgtt attttgactt gatgcctttt gaataacttt caatagaatt 4441 gtctaaaatt atcttactgg ttgttaggcc tttggtgtct cagagaagga gtctaggtct 4501 ttgatgtgtg atttaatctt ttatttgttt ataataaaaa atagactgat atgtaaaaaa 4561 aaaaaaaaaa aa //