LOCUS BC074984 936 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens CD274 molecule, mRNA (cDNA clone MGC:103912
IMAGE:30915301), complete cds.
ACCESSION BC074984
VERSION BC074984.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 936)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 936)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-JUN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 4, 2004 this sequence version replaced BC074984.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Genome Sequence Centre, British Columbia Cancer
Center
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRBU Plate: 2 Row: D Column: 2.
FEATURES Location/Qualifiers
source 1..936
/db_xref="H-InvDB:HIT000265491"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:103912 IMAGE:30915301"
/tissue_type="Pooled tissue, PCR rescued clones"
/clone_lib="NIH_MGC_271"
/note="Vector: pCR4 Topo TA with reversed insert"
gene 1..936
/gene="CD274"
/gene_synonym="B7-H"
/gene_synonym="B7H1"
/gene_synonym="PD-L1"
/gene_synonym="PDCD1L1"
/gene_synonym="PDL1"
/db_xref="GeneID:29126"
/db_xref="HGNC:HGNC:17635"
/db_xref="MIM:605402"
CDS 21..893
/gene="CD274"
/gene_synonym="B7-H"
/gene_synonym="B7H1"
/gene_synonym="PD-L1"
/gene_synonym="PDCD1L1"
/gene_synonym="PDL1"
/codon_start=1
/product="CD274 molecule"
/protein_id="AAH74984.1"
/db_xref="GeneID:29126"
/db_xref="HGNC:HGNC:17635"
/db_xref="MIM:605402"
/translation="MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPV
EKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQIT
DVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGY
PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEE
NHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQD
TNSKKQSDTHLEET"
BASE COUNT 296 a 198 c 217 g 225 t
ORIGIN
1 ctgcagggca ttccagaaag atgaggatat ttgctgtctt tatattcatg acctactggc
61 atttgctgaa cgcatttact gtcacggttc ccaaggacct atatgtggta gagtatggta
121 gcaatatgac aattgaatgc aaattcccag tagaaaaaca attagacctg gctgcactaa
181 ttgtctattg ggaaatggag gataagaaca ttattcaatt tgtgcatgga gaggaagacc
241 tgaaggttca gcatagtagc tacagacaga gggcccggct gttgaaggac cagctctccc
301 tgggaaatgc tgcacttcag atcacagatg tgaaattgca ggatgcaggg gtgtaccgct
361 gcatgatcag ctatggtggt gccgactaca agcgaattac tgtgaaagtc aatgccccat
421 acaacaaaat caaccaaaga attttggttg tggatccagt cacctctgaa catgaactga
481 catgtcaggc tgagggctac cccaaggccg aagtcatctg gacaagcagt gaccatcaag
541 tcctgagtgg taagaccacc accaccaatt ccaagagaga ggagaagctt ttcaatgtga
601 ccagcacact gagaatcaac acaacaacta atgagatttt ctactgcact tttaggagat
661 tagatcctga ggaaaaccat acagctgaat tggtcatccc agaactacct ctggcacatc
721 ctccaaatga aaggactcac ttggtaattc tgggagccat cttattatgc cttggtgtag
781 cactgacatt catcttccgt ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca
841 tccaagatac aaactcaaag aagcaaagtg atacacattt ggaggagacg taatccagca
901 ttggaacttc tgatcttcaa gcagggattc tcaacc
//