LOCUS BC071751 2508 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens chemokine (C-C motif) receptor 4, mRNA (cDNA clone
MGC:88293 IMAGE:30415446), complete cds.
ACCESSION BC071751
VERSION BC071751.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2508)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2508)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-JUN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Narayan Bhat
cDNA Library Preparation: CLONTECH Laboratories, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 57 Row: p Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 48762930.
FEATURES Location/Qualifiers
source 1..2508
/db_xref="H-InvDB:HIT000264571"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:88293 IMAGE:30415446"
/tissue_type="Blood, peripheral blood mononuclear cells
(PBMC) cytoplasmic poly A RNA is pooled sample from 3 and
6 hr after stimulation with PMA and Ionomycin. These
reagents are used to activate T- cells that results in
lymphokine and cytokine production."
/clone_lib="NIH_MGC_191"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..2508
/gene="CCR4"
/gene_synonym="CC-CKR-4"
/gene_synonym="ChemR13"
/gene_synonym="CKR4"
/gene_synonym="CMKBR4"
/gene_synonym="HGCN:14099"
/gene_synonym="K5-5"
/gene_synonym="MGC88293"
/db_xref="GeneID:1233"
/db_xref="HGNC:HGNC:1605"
/db_xref="MIM:604836"
CDS 169..1251
/gene="CCR4"
/gene_synonym="CC-CKR-4"
/gene_synonym="ChemR13"
/gene_synonym="CKR4"
/gene_synonym="CMKBR4"
/gene_synonym="HGCN:14099"
/gene_synonym="K5-5"
/gene_synonym="MGC88293"
/codon_start=1
/product="chemokine (C-C motif) receptor 4"
/protein_id="AAH71751.1"
/db_xref="GeneID:1233"
/db_xref="HGNC:HGNC:1605"
/db_xref="MIM:604836"
/translation="MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPP
LYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQ
WVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLA
TWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIM
LFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDC
TFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGL
LQIYSADTPSSSYTQSTMDHDLHDAL"
BASE COUNT 659 a 580 c 537 g 732 t
ORIGIN
1 gctcacagga agccacgcac ccttgaaagg caccgggtcc ttcttagcat cgtgcttcct
61 gagcaagcct ggcattgcct cacagacctt cctcagagcc gctttcagaa aagcaagctg
121 cttctggttg ggcccagacc tgccttgagg agcctgtaga gttaaaaaat gaaccccacg
181 gatatagcag acaccaccct cgatgaaagc atatacagca attactatct gtatgaaagt
241 atccccaagc cttgcaccaa agaaggcatc aaggcatttg gggagctctt cctgccccca
301 ctgtattcct tggtttttgt atttggtctg cttggaaatt ctgtggtggt tctggtcctg
361 ttcaaataca agcggctcag gtccatgact gatgtgtacc tgctcaacct tgccatctcg
421 gatctgctct tcgtgttttc cctccctttt tggggctact atgcagcaga ccagtgggtt
481 tttgggctag gtctgtgcaa gatgatttcc tggatgtact tggtgggctt ttacagtggc
541 atattctttg tcatgctcat gagcattgat agatacctgg caattgtgca cgcggtgttt
601 tccttgaggg caaggacctt gacttatggg gtcatcacca gtttggctac atggtcagtg
661 gctgtgttcg cctcccttcc tggctttctg ttcagcactt gttatactga gcgcaaccat
721 acctactgca aaaccaagta ctctctcaac tccacgacgt ggaaggttct cagctccctg
781 gaaatcaaca ttctcggatt ggtgatcccc ttagggatca tgctgttttg ctactccatg
841 atcatcagga ccttgcagca ttgtaaaaat gagaagaaga acaaggcggt gaagatgatc
901 tttgccgtgg tggtcctctt ccttgggttc tggacacctt acaacatagt gctcttccta
961 gagaccctgg tggagctaga agtccttcag gactgcacct ttgaaagata cttggactat
1021 gccatccagg ccacagaaac tctggctttt gttcactgct gccttaatcc catcatctac
1081 ttttttctgg gggagaaatt tcgcaagtac atcctacagc tcttcaaaac ctgcaggggc
1141 ctttttgtgc tctgccaata ctgtgggctc ctccaaattt actctgctga cacccccagc
1201 tcatcttaca cgcagtccac catggatcat gatctccatg atgctctgta gaaaaatgaa
1261 atggtgaaat gcagagtcaa tgaactttcc acattcagag cttacttaaa attgtatttt
1321 agtaagagat tcctgagcca gtgtcaggag gaaggcttac acccacagtg gaaagacagc
1381 ttctcatcct gcaggcagct ttttctctcc cactagacaa gtccagcctg gcaagggttc
1441 acctgggctg aggcatcctt cctcacacca ggcttgcctg caggcatgag tcagtctgat
1501 gagaactctg agcagtgctt gaatgaagtt gtaggtaata ttgcaaggca aagactattc
1561 ccttctaacc tgaactgatg ggtttctcca gagggaattg cagagtactg gctgatggag
1621 taaatcgcta ccttttgctg tggcaaatgg gccctctaat taatttcttg cttttgcgga
1681 acaatataga taactgtttt tctaataaca tatctcaggc aaagtatatt ccattgagcc
1741 agatgtatga agaaacaatt agtgaagtga tgaaaccaga tctcaattat ttattgtaaa
1801 ggattatctg ttaattgaaa ccaaactttt tatactgata taagggtaag gatatgaaga
1861 cattagccaa ggtctgcttt ccaaacgtga actacaaggc attcaaaatc caaacatatt
1921 tatgaaaatt caaacacagt ttctcacttg tttgtggaca tgttttgttc taattttaac
1981 agaggaatat taaaaaattt taaataggct gggattacag gtgtgagcca tcacgcccgg
2041 ccacttgttt attttttatt ttattttatt ttatttttga gatggagtct cactctgtca
2101 cccaagctgg agtgcagtgg cactcggttc actgcaaagt ctgcctccca ggttcaagcg
2161 attctcctgc ctcagcttct caagcagctg ggattagagg tgtgcaccac tacgccaggc
2221 tagtttttgt atttttagta gagatggggt ttcaccatgt tggccaggct agtcttgaac
2281 tcctgacctc aggtgatctg cctgcttcag cctcccaaag tgctgggatt acaggcgtga
2341 gccacctcgc ccagccaagg tcttttactt gtttataaac agtctcttca taattaaaat
2401 taaggattaa taaagtatga caatacctcc ttaatcattt tgaagtgcct gctatcaatt
2461 gaaataaaaa caatcaacca aaaaaaaaaa aaaaaaaaaa aaaaaaaa
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