LOCUS BC071562 4275 bp mRNA linear HUM 28-JUL-2005
DEFINITION Homo sapiens Notch homolog 2 (Drosophila), mRNA (cDNA clone
MGC:87008 IMAGE:4822955), complete cds.
ACCESSION BC071562
VERSION BC071562.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4275)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4275)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-JUN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 167 Row: f Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 24041034.
FEATURES Location/Qualifiers
source 1..4275
/db_xref="H-InvDB:HIT000264391"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:87008 IMAGE:4822955"
/tissue_type="Testis"
/clone_lib="NIH_MGC_97"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4275
/gene="NOTCH2"
/gene_synonym="hN2"
/db_xref="GeneID:4853"
/db_xref="MIM:600275"
CDS 247..3954
/gene="NOTCH2"
/gene_synonym="hN2"
/codon_start=1
/product="NOTCH2 protein"
/protein_id="AAH71562.2"
/db_xref="GeneID:4853"
/db_xref="MIM:600275"
/translation="MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTY
HNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ
YSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCT
TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC
DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCV
DGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDD
CSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDT
NPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG
PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQ
CVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVL
CEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCID
LVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNID
IDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG
YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDE
CASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFES
YTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDD
CLANPCQNGGSCMDGVNTFSCLCLPGFTGDKYQTDMNECLSEPCKNGGTCSDYVNSYT
CKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECS
SHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCL
CPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYC
EEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCID
LVNHFKCSCPPGTRGMKSSLSIFHPGHCLKL"
BASE COUNT 1019 a 1022 c 1165 g 1069 t
ORIGIN
1 gttgcacacc cgagaaagtt tcagccaaac ttcgggcggc ggctgaggcg gcggccgagg
61 agcggcggac tcggggcgcg gggagtcgag gcatttgcgc ctgggcttcg gagcgtagcg
121 ccagggcctg agcctttgaa gcaggaggag gggaggagag agtggggctc ctctatcggg
181 accccctccc catgtggatc tgcccaggcg gcggcggcgg cggcggagga ggaggcgacc
241 gagaagatgc ccgccctgcg ccccgctctg ctgtgggcgc tgctggcgct ctggctgtgc
301 tgcgcggccc ccgcgcatgc attgcagtgt cgagatggct atgaaccctg tgtaaatgaa
361 ggaatgtgtg ttacctacca caatggcaca ggatactgca aatgtccaga aggcttcttg
421 ggggaatatt gtcaacatcg agacccctgt gagaagaacc gctgccagaa tggtgggact
481 tgtgtggccc aggccatgct ggggaaagcc acgtgccgat gtgcctcagg gtttacagga
541 gaggactgcc agtactcaac atctcatcca tgctttgtgt ctcgaccctg cctgaatggc
601 ggcacatgcc atatgctcag ccgggatacc tatgagtgca cctgtcaagt cgggtttaca
661 ggtaaggagt gccaatggac ggatgcctgc ctgtctcatc cctgtgcaaa tggaagtacc
721 tgtaccactg tggccaacca gttctcctgc aaatgcctca caggcttcac agggcagaaa
781 tgtgagactg atgtcaatga gtgtgacatt ccaggacact gccagcatgg tggcacctgc
841 ctcaacctgc ctggttccta ccagtgccag tgccctcagg gcttcacagg ccagtactgt
901 gacagcctgt atgtgccctg tgcaccctca ccttgtgtca atggaggcac ctgtcggcag
961 actggtgact tcacttttga gtgcaactgc cttccaggtt ttgaagggag cacctgtgag
1021 aggaatattg atgactgccc taaccacagg tgtcagaatg gaggggtttg tgtggatggg
1081 gtcaacactt acaactgccg ctgtccccca caatggacag gacagttctg cacagaggat
1141 gtggatgaat gcctgctgca gcccaatgcc tgtcaaaatg ggggcacctg tgccaaccgc
1201 aatggaggct atggctgtgt atgtgtcaac ggctggagtg gagatgactg cagtgagaac
1261 attgatgatt gtgccttcgc ctcctgtact ccaggctcca cctgcatcga ccgtgtggcc
1321 tccttctctt gcatgtgccc agaggggaag gcaggtctcc tgtgtcatct ggatgatgca
1381 tgcatcagca atccttgcca caagggggca ctgtgtgaca ccaaccccct aaatgggcaa
1441 tatatttgca cctgcccaca aggctacaaa ggggctgact gcacagaaga tgtggatgaa
1501 tgtgccatgg ccaatagcaa tccttgtgag catgcaggaa aatgtgtgaa cacggatggc
1561 gccttccact gtgagtgtct gaagggttat gcaggacctc gttgtgagat ggacatcaat
1621 gagtgccatt cagacccctg ccagaatgat gctacctgtc tggataagat tggaggcttc
1681 acatgtctgt gcatgccagg tttcaaaggt gtgcattgtg aattagaaat aaatgaatgt
1741 cagagcaacc cttgtgtgaa caatgggcag tgtgtggata aagtcaatcg tttccagtgc
1801 ctgtgtcctc ctggtttcac tgggccagtt tgccagattg atattgatga ctgttccagt
1861 actccgtgtc tgaatggggc aaagtgtatc gatcacccga atggctatga atgccagtgt
1921 gccacaggtt tcactggtgt gttgtgtgag gagaacattg acaactgtga ccccgatcct
1981 tgccaccatg gtcagtgtca ggatggtatt gattcctaca cctgcatctg caatcccggg
2041 tacatgggcg ccatctgcag tgaccagatt gatgaatgtt acagcagccc ttgcctgaac
2101 gatggtcgct gcattgacct ggtcaatggc taccagtgca actgccagcc aggcacgtca
2161 ggggttaatt gtgaaattaa ttttgatgac tgtgcaagta acccttgtat ccatggaatc
2221 tgtatggatg gcattaatcg ctacagttgt gtctgctcac caggattcac agggcagaga
2281 tgtaacattg acattgatga gtgtgcctcc aatccctgtc gcaagggtgc aacatgtatc
2341 aacggtgtga atggtttccg ctgtatatgc cccgagggac cccatcaccc cagctgctac
2401 tcacaggtga acgaatgcct gagcaatccc tgcatccatg gaaactgtac tggaggtctc
2461 agtggatata agtgtctctg tgatgcaggc tgggttggca tcaactgtga agtggacaaa
2521 aatgaatgcc tttcgaatcc gtgccagaat ggaggaactt gtgacaatct ggtgaatgga
2581 tacaggtgta cttgcaagaa gggctttaaa ggctataact gccaggtgaa tattgatgaa
2641 tgtgcctcaa atccatgcct gaaccaagga acctgctttg atgacataag tggctacact
2701 tgccactgtg tgctgccata cacaggcaag aattgtcaga cagtattggc tccctgttcc
2761 ccaaaccctt gtgagaatgc tgctgtttgc aaagagtcac caaattttga gagttatact
2821 tgcttgtgtg ctcctggctg gcaaggtcag cggtgtacca ttgacattga cgagtgtatc
2881 tccaagccct gcatgaacca tggtctctgc cataacaccc agggcagcta catgtgtgaa
2941 tgtccaccag gcttcagtgg tatggactgt gaggaggaca ttgatgactg ccttgccaat
3001 ccttgccaga atggaggttc ctgtatggat ggagtgaata ctttctcctg cctctgcctt
3061 ccgggtttca ctggggataa gtaccagaca gacatgaatg agtgtctgag tgaaccctgt
3121 aagaatggag ggacctgctc tgactacgtc aacagttaca cttgcaagtg ccaggcagga
3181 tttgatggag tccattgtga gaacaacatc aatgagtgca ctgagagctc ctgtttcaat
3241 ggtggcacat gtgttgatgg gattaactcc ttctcttgct tgtgccctgt gggtttcact
3301 ggatccttct gcctccatga gatcaatgaa tgcagctctc atccatgcct gaatgaggga
3361 acgtgtgttg atggcctggg tacctaccgc tgcagctgcc ccctgggcta cactgggaaa
3421 aactgtcaga ccctggtgaa tctctgcagt cggtctccat gtaaaaacaa aggtacttgc
3481 gttcagaaaa aagcagagtc ccagtgccta tgtccatctg gatgggctgg tgcctattgt
3541 gacgtgccca atgtctcttg tgacatagca gcctccagga gaggtgtgct tgttgaacac
3601 ttgtgccagc actcaggtgt ctgcatcaat gctggcaaca cgcattactg tcagtgcccc
3661 ctgggctata ctgggagcta ctgtgaggag caactcgatg agtgtgcgtc caacccctgc
3721 cagcacgggg caacatgcag tgacttcatt ggtggataca gatgcgagtg tgtcccaggc
3781 tatcagggtg tcaactgtga gtatgaagtg gatgagtgcc agaatcagcc ctgccagaat
3841 ggaggcacct gtattgacct tgtgaaccat ttcaagtgct cttgcccacc aggcactcgg
3901 ggtatgaaat catccttatc cattttccat ccagggcatt gtcttaagtt ataaatccat
3961 tcttagtgtt caggggattt tataaaatta aagataggaa gactagcttc attccaagca
4021 tttagttcta catcctagta attcaagcca ttttattctc ccatctcttg ctagctctga
4081 tgttgtggtt tatgttgtca gttttatctg gttgtttggc atcttgatat tccatgaaac
4141 acagaatatg gaagggatac aacattagca taacattaaa aaattagcct ggtcagtaag
4201 atttcttgtt gcttcacaga aaagcaacta atggcctcta aaataaacaa tttacattta
4261 aaaaaaaaaa aaaaa
//