LOCUS BC071181 5766 bp mRNA linear HUM 04-AUG-2008
DEFINITION Homo sapiens transforming growth factor, beta receptor 1, mRNA
(cDNA clone MGC:71700 IMAGE:30344890), complete cds.
ACCESSION BC071181
VERSION BC071181.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5766)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5766)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-JUN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. Stefan Hansson
cDNA Library Preparation: Michael Brownstein / Ted Usdin
Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 133 Row: h Column: 22
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 66346739.
FEATURES Location/Qualifiers
source 1..5766
/db_xref="H-InvDB:HIT000264383"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:71700 IMAGE:30344890"
/tissue_type="Placenta, normal"
/clone_lib="NIH_MGC_147"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..5766
/gene="TGFBR1"
/gene_synonym="AAT5"
/gene_synonym="ACVRLK4"
/gene_synonym="ALK-5"
/gene_synonym="ALK5"
/gene_synonym="LDS1A"
/gene_synonym="LDS2A"
/gene_synonym="SKR4"
/gene_synonym="TGFR-1"
/db_xref="GeneID:7046"
/db_xref="HGNC:HGNC:11772"
/db_xref="MIM:190181"
CDS 96..1376
/gene="TGFBR1"
/gene_synonym="AAT5"
/gene_synonym="ACVRLK4"
/gene_synonym="ALK-5"
/gene_synonym="ALK5"
/gene_synonym="LDS1A"
/gene_synonym="LDS2A"
/gene_synonym="SKR4"
/gene_synonym="TGFR-1"
/codon_start=1
/product="TGFBR1 protein"
/protein_id="AAH71181.1"
/db_xref="GeneID:7046"
/db_xref="HGNC:HGNC:11772"
/db_xref="MIM:190181"
/translation="MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKD
NFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCN
QDHCNKIELPTTGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSR
EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY
TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG
LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEI
ARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAK
IMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
BASE COUNT 1682 a 965 c 1217 g 1902 t
ORIGIN
1 gcggcggcta gggaggtggg gcgaggcgag gtttgctggg gtgaggcagc ggcgcggccg
61 ggccgggccg ggccacaggc ggtggcggcg ggaccatgga ggcggcggtc gctgctccgc
121 gtccccggct gctcctcctc gtgctggcgg cggcggcggc ggcggcggcg gcgctgctcc
181 cgggggcgac ggcgttacag tgtttctgcc acctctgtac aaaagacaat tttacttgtg
241 tgacagatgg gctctgcttt gtctctgtca cagagaccac agacaaagtt atacacaaca
301 gcatgtgtat agctgaaatt gacttaattc ctcgagatag gccgtttgta tgtgcaccct
361 cttcaaaaac tgggtctgtg actacaacat attgctgcaa tcaggaccat tgcaataaaa
421 tagaacttcc aactactggt ttaccattgc ttgttcagag aacaattgcg agaactattg
481 tgttacaaga aagcattggc aaaggtcgat ttggagaagt ttggagagga aagtggcggg
541 gagaagaagt tgctgttaag atattctcct ctagagaaga acgttcgtgg ttccgtgagg
601 cagagattta tcaaactgta atgttacgtc atgaaaacat cctgggattt atagcagcag
661 acaataaaga caatggtact tggactcagc tctggttggt gtcagattat catgagcatg
721 gatccctttt tgattactta aacagataca cagttactgt ggaaggaatg ataaaacttg
781 ctctgtccac ggcgagcggt cttgcccatc ttcacatgga gattgttggt acccaaggaa
841 agccagccat tgctcataga gatttgaaat caaagaatat cttggtaaag aagaatggaa
901 cttgctgtat tgcagactta ggactggcag taagacatga ttcagccaca gataccattg
961 atattgctcc aaaccacaga gtgggaacaa aaaggtacat ggcccctgaa gttctcgatg
1021 attccataaa tatgaaacat tttgaatcct tcaaacgtgc tgacatctat gcaatgggct
1081 tagtattctg ggaaattgct cgacgatgtt ccattggtgg aattcatgaa gattaccaac
1141 tgccttatta tgatcttgta ccttctgacc catcagttga agaaatgaga aaagttgttt
1201 gtgaacagaa gttaaggcca aatatcccaa acagatggca gagctgtgaa gccttgagag
1261 taatggctaa aattatgaga gaatgttggt atgccaatgg agcagctagg cttacagcat
1321 tgcggattaa gaaaacatta tcgcaactca gtcaacagga aggcatcaaa atgtaattct
1381 acagctttgc ctgaactctc cttttttctt cagatctgct cctgggtttt aatttgggag
1441 gtcaattgtt ctacctcact gagagggaac agaaggatat tgcttccttt tgcagcagtg
1501 taataaagtc aattaaaaac ttcccaggat ttctttggac ccaggaaaca gccatgtggg
1561 tcctttctgt gcactatgaa cgcttctttc ccaggacaga aaatgtgtag tctaccttta
1621 ttttttatta acaaaacttg ttttttaaaa agatgattgc tggtcttaac tttaggtaac
1681 tctgctgtgc tggagatcat ctttaagggc aaaggagttg gattgctgaa ttacaatgaa
1741 acatgtctta ttactaaaga aagtgattta ctcctggtta gtacattctc agaggattct
1801 gaaccactag agtttccttg attcagactt tgaatgtact gttctatagt ttttcaggat
1861 cttaaaacta acacttataa aactcttatc ttgagtctaa aaatgacctc atatagtagt
1921 gaggaacata attcatgcaa ttgtattttg tatactatta ttgttctttc acttattcag
1981 aacattacat gccttcaaaa tgggattgta ctataccagt aagtgccact tctgtgtctt
2041 tctaatggaa atgagtagaa ttgctgaaag tctctatgtt aaaacctata gtgtttgaat
2101 tcaaaaagct tatttatctg ggtaacccaa actttttctg ttttgttttt ggaagggttt
2161 ttgtggtatg tcatttggta ttctattctg aaaatgcctt tctcctacca aaatgtgctt
2221 aagccactaa agaaatgaag tggcattaat tagtaaatta ttagcatggt catgtttgaa
2281 tattctcaca tcaagctttt gcattttaat tgtgttgtct aagtatactt ttaaaaaatc
2341 aagtggcact ctagatgctt atagtacttt aatatttgta gcatacagac taatttttct
2401 aaaagggaaa gtctgtctag ctgcttgtga aaagttatgt ggtattctgt aagccatttt
2461 tttctttatc tgttcaaaga cttatttttt aagacatgaa ttacatttaa aattagaata
2521 tggttaatat taaataatag gcctttttct aggaaggcga aggtagttaa taatttgaat
2581 agataacaga tgtgcaagaa agtcacattt gttatgtatg taggagtaaa cgttcggtgg
2641 atcctctgtc tttgtaactg aggttagagc tagtgtggtt ttgaggtctc actacacttt
2701 gaggaaggca gcttttaatt cagtgtttcc ttatgtgtgc gtacattgca actgcttaca
2761 tgtaatttat gtaatgcatt cagtgcaccc ttgttacttg ggagaggtgg tagctaaaga
2821 acattctgag tataggtttt tctccattta cagatgtctt tggtcaaata ttgaaagcaa
2881 acttgtcatg gtcttcttac attaagttga aactagctta taataactgg tttttacttc
2941 caatgctatg aagtctctgc agggctttta cagttttcga agtcctttta tcactgtgat
3001 cttattctga ggggagaaaa aactatcata gctctgaggc aagacttcga ctttatagtg
3061 ctatcagttc cccgatacag ggtcagagta acccatacag tattttggtc aggaagagaa
3121 agtggccatt tacactgaat gagttgcatt ctgataatgt cttatctctt atacgtagaa
3181 taaatttgaa agactatttg atcttaaaac caaagtaatt ttagaatgag tgacatatta
3241 cataggaatt tagtgtcaat ttcatgtgtt taaaaacatc atgggaaaaa tgcttagagg
3301 ttactatttt gactacaaag ttgagttttt ttctgtagtt accataattt cattgaagca
3361 aatgaatgag tttgagaggt ttgtttttat agttgtgttg tattacttgt ttaataataa
3421 tctctaattc tgtgatcagg tacttttttt gtgggggttt tttttttgtt tttttttttt
3481 tttgttgttg tttttgggcc atttctaagc ctaccagatc tgctttatga aatccagggg
3541 accaatgcat tttatcacta aaactatttt tatataattt taagaatata ccaaaagttg
3601 tctgatttaa agttgtaata catgatttct cactttcatg taaggttatc cacttttgct
3661 gaagatattt tttattgaat caaagattga gttacaatta tacttttctt acctaagtgg
3721 ataaaatgta cttttgatga atcagggaat ttttttaaag ttggagttta gttctaaatt
3781 gactttacgt attactgcag ttaattcctt ttttggctag ggatggtttg ataaaccaca
3841 attggctgat attgaaaatg aaagaaactt aaaaggtggg atggatcatg attactgtcg
3901 ataactgcag ataaatttga ttagagtaat aattttgtca tttaaaaaca cagttgttta
3961 tactgcccat cctaggatgc tcaccttcca agattcaacg tggctaaaac atcttctggt
4021 aaattgtgcg tccatattca ttttgtcagt agccaggaga aatggggatg ggggaaatac
4081 gacttagtga ggcatagaca tccctggtcc atcctttctg tctccagctg tttcttggaa
4141 cctgctctcc tgcttgctgg tccctgacgc agagaccgtt gcctccccca cagccgtttg
4201 actgaaggct gctctggaga cctagagtaa aacggctgat ggaagttgtg ggacccactt
4261 ccatttcctt cagtcattag aggtggaagg gaggggtctc caagtttgga gattgagcag
4321 atgaggcttg ggatgcccct gctttgactt cagccatgga tgaggagtgg gatggcagca
4381 aggtggctcc tgtggcagtg gagttgtgcc agaaacagtg gccagttgta tcgcctataa
4441 gacagggtaa ggtctgaaga gctgagcctg taattctgct gtaataatga tagtgctcaa
4501 gaagtgcctt gagttggtgt acagtgccat ggccatcaag aatcccagat ttcaggtttt
4561 attacaaaat gtaagtggtc acttggcgat tttgtagtac atgcatgagt tacctttttt
4621 ctctatgtct gagaactgtc agattaaaac aagatggcaa agagatcgtt agagtgcaca
4681 acaaaatcac tatcccatta gacacatcat caaaagctta tttttattct tgcactggaa
4741 gaatcgtaag tcaactgttt cttgaccatg gcagtgttct ggctccaaat ggtagtgatt
4801 ccaaataatg gttctgttaa cactttggca gaaaatgcca gctcagatat tttgagatac
4861 taaggattat ctttggacat gtactgcagc ttcttgtctc tgttttggat tactggaata
4921 cccatgggcc ctctcaagag tgctggactt ctaggacatt aagatgattg tcagtacatt
4981 aaacttttca atcccattat gcaatcttgt ttgtaaatgt aaacttctaa aaatatggtt
5041 aataacattc aacctgttta ttacaactta aaaggaactt cagtgaattt gtttttattt
5101 tttaacaaga tttgtgaact gaatatcatg aaccatgttt tgatacccct ttttcacgtt
5161 gtgccaacgg aatagggtgt ttgatatttc ttcatatgtt aaggagatgc ttcaaaatgt
5221 caattgcttt aaacttaaat tacctctcaa gagaccaagg tacatttacc tcattgtgta
5281 tataatgttt aatatttgtc agagcattct ccaggtttgc agttttattt ctataaagta
5341 tgggtattat gttgctcagt tactcaaatg gtactgtatt gtttatattt gtaccccaaa
5401 taacatcgtc tgtactttct gttttctgta ttgtatttgt gcaggattct ttaggcttta
5461 tcagtgtaat ttctgccttt taagatatgt acagaaaatg tccatataaa tttccattga
5521 agtcgaatga tactgagaag cctgtaaaga ggagaaaaaa cataagctgt gtttccccat
5581 aagttttttt aaattgtata ttgtatttgt agtaatattc caaaagaatg taaataggaa
5641 atagaagagt gatgcttatg ttaagtccta acactacagt agaagaatgg aagcagtgca
5701 aataaattac atttttccca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa
5761 aaaaaa
//