LOCUS BC068050 1306 bp mRNA linear HUM 09-SEP-2005
DEFINITION Homo sapiens caspase 8, apoptosis-related cysteine peptidase, mRNA
(cDNA clone MGC:78473 IMAGE:6421760), complete cds.
ACCESSION BC068050
VERSION BC068050.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1306)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1306)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (24-MAR-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 54 Row: n Column: 15
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15718707.
FEATURES Location/Qualifiers
source 1..1306
/db_xref="H-InvDB:HIT000262911"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:78473 IMAGE:6421760"
/tissue_type="Lung, large cell carcinoma"
/clone_lib="NIH_MGC_18"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1306
/gene="CASP8"
/gene_synonym="FLICE"
/gene_synonym="MACH"
/gene_synonym="MCH5"
/db_xref="GeneID:841"
/db_xref="MIM:601763"
CDS 91..927
/gene="CASP8"
/gene_synonym="FLICE"
/gene_synonym="MACH"
/gene_synonym="MCH5"
/codon_start=1
/product="CASP8 protein"
/protein_id="AAH68050.1"
/db_xref="GeneID:841"
/db_xref="MIM:601763"
/translation="MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALML
FQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR
VMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDIL
KRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPR
GYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGSHSVAQAGVQWCDLGSLQPPPPW
FG"
BASE COUNT 390 a 273 c 303 g 340 t
ORIGIN
1 gaagttttct ctttctctcg gagaccagat tctgcctttc tgctggaggg aagtgttttc
61 acagattata ttctcctgcc ttttaaaaag atggacttca gcagaaatct ttatgatatt
121 ggggaacaac tggacagtga agatctggcc tccctcaagt tcctgagcct ggactacatt
181 ccgcaaagga agcaagaacc catcaaggat gccttgatgt tattccagag actccaggaa
241 aagagaatgt tggaggaaag caatctgtcc ttcctgaagg agctgctctt ccgaattaat
301 agactggatt tgctgattac ctacctaaac actagaaagg aggagatgga aagggaactt
361 cagacaccag gcagggctca aatttctgcc tacagggtca tgctctatca gatttcagaa
421 gaagtgagca gatcagaatt gaggtctttt aagtttcttt tgcaagagga aatctccaaa
481 tgcaaactgg atgatgacat gaacctgctg gatattttca tagagatgga gaagagggtc
541 atcctgggag aaggaaagtt ggacatcctg aaaagagtct gtgcccaaat caacaagagc
601 ctgctgaaga taatcaacga ctatgaagaa ttcagcaaag gggaggagtt gtgtggggta
661 atgacaatct cggactctcc aagagaacag gatagtgaat cacagacttt ggacaaagtt
721 taccaaatga aaagcaaacc tcggggatac tgtctgatca tcaacaatca caattttgca
781 aaagcacggg agaaagtgcc caaacttcac agcattaggg acaggaatgg aacacacttg
841 gatgcagggt ctcactctgt tgcccaggct ggagtgcagt ggtgtgatct cggctcactg
901 cagcctccgc ctccctggtt cgggtgattc tcctgcctca gcctcccagg tagctgggac
961 tgcaggcaca caccaccaca catggctgat ttttgtattt ttagtggaga tggggttttg
1021 ccatgttggc caggctggtc ttgaactcct gacctcaagt gatccgcctg cctcggcctc
1081 ccaaagtgct ggaattacag gtgtcagcca cctgtacctg gtccctgcta acatttgatt
1141 tgtttattta agcaaatcta agcctttaaa aaggcacaga gattaagtcc attgattaca
1201 tcattcgtca ctatgcgctt ggtattgaaa aaaatatttt ggacccttga tttgtattct
1261 tttaaaatta aaacatttct attaaaataa aaaaaaaaaa aaaaaa
//