LOCUS BC065492 3893 bp mRNA linear HUM 15-JUL-2006 DEFINITION Homo sapiens beta-site APP-cleaving enzyme 1, mRNA (cDNA clone MGC:71162 IMAGE:6538154), complete cds. ACCESSION BC065492 VERSION BC065492.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3893) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3893) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (26-JAN-2004) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 50 Row: n Column: 6. FEATURES Location/Qualifiers source 1..3893 /db_xref="H-InvDB:HIT000261901" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:71162 IMAGE:6538154" /tissue_type="Lung, epidermoid carcinoma" /clone_lib="NIH_MGC_101" /lab_host="DH10B" /note="Vector: pOTB7" gene 1..3893 /gene="BACE1" /gene_synonym="ASP2" /gene_synonym="HSPC104" /gene_synonym="KIAA1149" /db_xref="GeneID:23621" /db_xref="HGNC:HGNC:933" /db_xref="MIM:604252" CDS 462..1967 /gene="BACE1" /gene_synonym="ASP2" /gene_synonym="HSPC104" /gene_synonym="KIAA1149" /codon_start=1 /product="beta-site APP-cleaving enzyme 1" /protein_id="AAH65492.1" /db_xref="GeneID:23621" /db_xref="HGNC:HGNC:933" /db_xref="MIM:604252" /translation="MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLP RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQT DESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK" BASE COUNT 897 a 1116 c 1005 g 875 t ORIGIN 1 acaagtcttt ccgcctcccc agcccgcccg ggagctgcga gccgcgagct ggattatggt 61 ggcctgagca gccaacgcag ccgcaggagc ccggagccct tgcccctgcc cgcgccgccg 121 cccgccgggg ggaccaggga agccgccacc ggcccgccat gcccgcccct cccagccccg 181 ccgggagccc gcgcccgctg cccaggctgg ccgccgccgt gccgatgtag cgggctccgg 241 atcccagcct ctcccctgct cccgtgctct gcggatctcc cctgaccgct ctccacagcc 301 cggacccggg ggctggccca gggccctgca ggccctggcg tcctgatgcc cccaagctcc 361 ctctcctgag aagccaccag caccacccag acttgggggc aggcgccagg gacggacgtg 421 ggccagtgcg agcccagagg gcccgaaggc cggggcccac catggcccaa gccctgccct 481 ggctcctgct gtggatgggc gcgggagtgc tgcctgccca cggcacccag cacggcatcc 541 ggctgcccct gcgcagcggc ctggggggcg cccccctggg gctgcggctg ccccgggaga 601 ccgacgaaga gcccgaggag cccggccgga ggggcagctt tgtggagatg gtggacaacc 661 tgaggggcaa gtcggggcag ggctactacg tggagatgac cgtgggcagc cccccgcaga 721 cgctcaacat cctggtggat acaggcagca gtaactttgc agtgggtgct gccccccacc 781 ccttcctgca tcgctactac cagaggcagc tgtccagcac ataccgggac ctccggaagg 841 gtgtgtatgt gccctacacc cagggcaagt gggaagggga gctgggcacc gacctggtaa 901 gcatccccca tggccccaac gtcactgtgc gtgccaacat tgctgccatc actgaatcag 961 acaagttctt catcaacggc tccaactggg aaggcatcct ggggctggcc tatgctgaga 1021 ttgccaggcc tgacgactcc ctggagcctt tctttgactc tctggtaaag cagacccacg 1081 ttcccaacct cttctccctg cagctttgtg gtgctggctt ccccctcaac cagtctgaag 1141 tgctggcctc tgtcggaggg agcatgatca ttggaggtat cgaccactcg ctgtacacag 1201 gcagtctctg gtatacaccc atccggcggg agtggtatta tgaggtgatc attgtgcggg 1261 tggagatcaa tggacaggat ctgaaaatgg actgcaagga gtacaactat gacaagagca 1321 ttgtggacag tggcaccacc aaccttcgtt tgcccaagaa agtgtttgaa gctgcagtca 1381 aatccatcaa ggcagcctcc tccacggaga agttccctga tggtttctgg ctaggagagc 1441 agctggtgtg ctggcaagca ggcaccaccc cttggaacat tttcccagtc atctcactct 1501 acctaatggg tgaggttacc aaccagtcct tccgcatcac catccttccg cagcaatacc 1561 tgcggccagt ggaagatgtg gccacgtccc aagacgactg ttacaagttt gccatctcac 1621 agtcatccac gggcactgtt atgggagctg ttatcatgga gggcttctac gttgtctttg 1681 atcgggcccg aaaacgaatt ggctttgctg tcagcgcttg ccatgtgcac gatgagttca 1741 ggacggcagc ggtggaaggc ccttttgtca ccttggacat ggaagactgt ggctacaaca 1801 ttccacagac agatgagtca accctcatga ccatagccta tgtcatggct gccatctgcg 1861 ccctcttcat gctgccactc tgcctcatgg tgtgtcagtg gcgctgcctc cgctgcctgc 1921 gccagcagca tgatgacttt gctgatgaca tctccctgct gaagtgagga ggcccatggg 1981 cagaagatag agattcccct ggaccacacc tccgtggttc actttggtca caagtaggag 2041 acacagatgg cacctgtggc cagagcacct caggaccctc cccacccacc aaatgcctct 2101 gccttgatgg agaaggaaaa ggctggcaag gtgggttcca gggactgtac ctgtaggaaa 2161 cagaaaagag aagaaagaag cactctgctg gcgggaatac tcttggtcac ctcaaattta 2221 agtcgggaaa ttctgctgct tgaaacttca gccctgaacc tttgtccacc attcctttaa 2281 attctccaac ccaaagtatt cttcttttct tagtttcaga agtactggca tcacacgcag 2341 gttaccttgg cgtgtgtccc tgtggtaccc tggcagagaa gagaccaagc ttgtttccct 2401 gctggccaaa gtcagtagga gaggatgcac agtttgctat ttgctttaga gacagggact 2461 gtataaacaa gcctaacatt ggtgcaaaga ttgcctcttg aattaaaaaa aaaaactaga 2521 ttgactattt atacaaatgg gggcggctgg aaagaggaga aggagaggga gtacaaagac 2581 agggaatagt gggatcaaag ctaggaaagg cagaaacaca accactcacc agtcctagtt 2641 ttagacctca tctccaagat agcatcccat ctcagaagat gggtgttgtt ttcaatgttt 2701 tcttttctgt ggttgcagcc tgaccaaaag tgagatggga agggcttatc tagccaaaga 2761 gctctttttt agctctctta aatgaagtgc ccactaagaa gttccactta acacatgaat 2821 ttctgccata ttaatttcat tgtctctatc tgaaccaccc tttattctac atatgatagg 2881 cagcactgaa atatcctaac cccctaagct ccaggtgccc tgtgggagag caactggact 2941 atagcagggc tgggctctgt cttcctggtc ataggctcac tctttccccc aaatcttcct 3001 ctggagcttt gcagccaagg tgctaaaagg aataggtagg agacctcttc tatctaatcc 3061 ttaaaagcat aatgttgaac attcattcaa cagctgatgc cctataaccc ctgcctggat 3121 ttcttcctat taggctataa gaagtagcaa gatctttaca taattcagag tggtttcatt 3181 gccttcctac cctctctaat ggcccctcca tttatttgac taaagcatca cacagtggca 3241 ctagcattat accaagagta tgagaaatac agtgctttat ggctctaaca ttactgcctt 3301 cagtatcaag gctgcctgga gaaaggatgg cagcctcagg gcttccttat gtcctccacc 3361 acaagagctc cttgatgaag gtcatctttt tcccctatcc tgttcttccc ctccccgctc 3421 ctaatggtac gtgggtaccc aggctggttc ttgggctagg tagtggggac caagttcatt 3481 acctccctat cagttctagc atagtaaact acggtaccag tgttagtggg aagagctggg 3541 ttttcctagt atacccactg catcctactc ctacctggtc aacccgctgc ttccaggtat 3601 gggacctgct aagtgtggaa ttacctgata agggagaggg aaatacaagg agggcctctg 3661 gtgttcctgg cctcagccag ctgcccacaa gccataaacc aataaaacaa gaatactgag 3721 tcagtttttt atctgggttc tcttcattcc cactgcactt ggtgctgctt tggctgactg 3781 ggaacacccc ataactacag agtctgacag gaagactgga gactgtccac ttctagctcg 3841 gaacttactg tgtaaataaa ctttcagaac tgctaaaaaa aaaaaaaaaa aaa //