LOCUS BC064354 1971 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens cytokine inducible SH2-containing protein, mRNA (cDNA
clone MGC:75431 IMAGE:4804249), complete cds.
ACCESSION BC064354
VERSION BC064354.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1971)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1971)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-DEC-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: James Cleaver, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 134 Row: n Column: 4
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 21614506.
FEATURES Location/Qualifiers
source 1..1971
/db_xref="H-InvDB:HIT000261317"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:75431 IMAGE:4804249"
/tissue_type="Skin, normal"
/clone_lib="NCI_CGAP_Skn3"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6.1"
gene 1..1971
/gene="CISH"
/gene_synonym="CIS"
/gene_synonym="CIS-1"
/gene_synonym="G18"
/gene_synonym="SOCS"
/db_xref="GeneID:1154"
/db_xref="HGNC:HGNC:1984"
/db_xref="MIM:602441"
CDS 19..795
/gene="CISH"
/gene_synonym="CIS"
/gene_synonym="CIS-1"
/gene_synonym="G18"
/gene_synonym="SOCS"
/codon_start=1
/product="cytokine inducible SH2-containing protein"
/protein_id="AAH64354.1"
/db_xref="GeneID:1154"
/db_xref="HGNC:HGNC:1984"
/db_xref="MIM:602441"
/translation="MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLE
EVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEG
TFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLV
QHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRS
SARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL"
BASE COUNT 445 a 590 c 512 g 424 t
ORIGIN
1 cgccgctgcc gcggggacat ggtcctctgc gttcagggac ctcgtccttt gctggctgtg
61 gagcggactg ggcagcggcc cctgtgggcc ccgtccctgg aactgcccaa gccagtcatg
121 cagcccttgc ctgctggggc cttcctcgag gaggtggcag agggtacccc agcccagaca
181 gagagtgagc caaaggtgct ggacccagag gaggatctgc tgtgcatagc caagaccttc
241 tcctaccttc gggaatctgg ctggtattgg ggttccatta cggccagcga ggcccgacaa
301 cacctgcaga agatgccaga aggcacgttc ttagtacgtg acagcacgca ccccagctac
361 ctgttcacgc tgtcagtgaa aaccactcgt ggccccacca atgtacgcat tgagtatgcc
421 gactccagct tccgtctgga ctccaactgc ttgtccaggc cacgcatcct ggcctttccg
481 gatgtggtca gccttgtgca gcactatgtg gcctcctgca ctgctgatac ccgaagcgac
541 agccccgatc ctgctcccac cccggccctg cctatgccta aggaggatgc gcctagtgac
601 ccagcactgc ctgctcctcc accagccact gctgtacacc taaaactggt gcagcccttt
661 gtacgcagaa gcagtgcccg cagcctgcaa cacctgtgcc gccttgtcat caaccgtctg
721 gtggccgacg tggactgcct gccactgccc cggcgcatgg ccgactacct ccgacagtac
781 cccttccagc tctgactgta cggggcaatc tgcccaccct cacccagtcg caccctggag
841 gggacatcag ccccagctgg acttgggccc ccactgtccc tcctccaggc atcctggtgc
901 ctgcatacct ctggcagctg gcccaggaag agccagcaag agcaaggcat gggagagggg
961 aggtgtcaca caacttggag gtaaatgccc ccaggccgca tgtggcttca ttatactgag
1021 ccatgtgtca gaggatgggg agacaggcag gaccttgtct cacctgtggg ctgggcccag
1081 acctccactc gcttgcctgc cctggccacc tgaactgtat gggcactctc agccctggtt
1141 tttcaatccc cagggtcggg taggacccct actggcagcc agcctctgtt tctgggagga
1201 tgacatgcag aggaactgag atcgacagtg actagtgacc ccttgttgag gggtaagcca
1261 ggctagggga ctgcacaatt atacactatt tatttattta ttctccttgg ggttggtgtc
1321 aggggcgagc caaccccacc tctatgccct gagccctggt agtccagaga ccccaactct
1381 gccctggctt ctctggttct tccctgtgga aagcccatcc tgagacatct tgctggaacc
1441 aaggcaatcc tggatgtcct ggtactgacc cacccgtctg tgaatgtgtc cactctcttc
1501 tgcccccagc catatttggg gaggatggac aactacaata ggtaagaaaa tgcagccgga
1561 gcctcagtcc ccagcagagc ctgtgtctca ccccctcaca ggacagagct gtatctgcat
1621 agagctggtc tcactgtggc gcaggccccg gggggagtgc ctgtgctgtc aggaagaggg
1681 ggtgctggtt tgagggccac cactgcagtt ctgctaggtc tgcttcctgc ccaggaaggt
1741 gcctgcacat gagaggagag aaatacacgt ctgataagac ttcatgaaat aataattata
1801 gcaaagaaca gtttggtggt cttttctctt ccactgattt ttctgtaatg acattatacc
1861 tttattacct ctttatttta ttacctctat aataaaatga tacctttcat gtaaaaaaaa
1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
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