LOCUS BC063856 2612 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens sprouty homolog 1, antagonist of FGF signaling
(Drosophila), mRNA (cDNA clone MGC:75188 IMAGE:6181674), complete
cds.
ACCESSION BC063856
VERSION BC063856.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2612)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2612)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. James R. Lupski
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 141 Row: c Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 40538725.
FEATURES Location/Qualifiers
source 1..2612
/db_xref="H-InvDB:HIT000261232"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:75188 IMAGE:6181674"
/tissue_type="Peripheral Nervous System, dorsal root
ganglion"
/clone_lib="Lupski_dorsal_root_ganglion"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2612
/gene="SPRY1"
/gene_synonym="hSPRY1"
/db_xref="GeneID:10252"
/db_xref="HGNC:HGNC:11269"
/db_xref="MIM:602465"
CDS 323..1282
/gene="SPRY1"
/gene_synonym="hSPRY1"
/codon_start=1
/product="sprouty homolog 1, antagonist of FGF signaling
(Drosophila)"
/protein_id="AAH63856.1"
/db_xref="GeneID:10252"
/db_xref="HGNC:HGNC:11269"
/db_xref="MIM:602465"
/translation="MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQI
KAIRGSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVL
PSNARGPILSRSTSTGSAASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQ
LIVDDLKGSLKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEY
GTCMCLVKGIFYHCSNDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPA
KGCLKLCRRCYDWIHRPGCRCKNSNTVYCKLESCPSRGQGKPS"
BASE COUNT 760 a 553 c 535 g 764 t
ORIGIN
1 tgcagagggc gcagctccac cgtggtaact tgcaatgtgg ccgcccctgc gctggcttct
61 ttctcctcgg ccctcggtga acccagcttt tcctttaaag catagacaaa tccttgctta
121 gggtcagcca gaccgtgggc ttgctttggg ctcccgcgtg gacgctgaag gctcttcatg
181 atttctcaga aaccttggtg ggccacccaa aaagtgtgtt ggaaatccac ggtgatcctt
241 aatatggtga tgggattgtc cgaaaaggat ttcagatgca tgccaggttt ccactgattg
301 ccagaactcg agatcactac acatggatcc ccaaaatcaa catggcagtg gcagttcgtt
361 agttgtgatc cagcagcctt ctttggatag ccgtcagaga ttagactatg agagagagat
421 tcagcctact gctattttgt ccttagacca gatcaaggcc ataagaggca gcaatgaata
481 cacagaaggg ccttcggtgg tgaaaagacc tgctcctcgg acagcaccaa gacaagaaaa
541 gcatgaaagg actcatgaaa tcataccaat taatgtgaat aataactacg agcacagaca
601 cacaagccac ctgggacatg cagtactccc aagtaatgcc aggggcccca ttttgagcag
661 atcaaccagc actggaagtg cagccagctc tgggagcaac agcagtgcct cttctgaaca
721 gggactgtta ggaaggtcac caccaaccag accagtccct ggtcataggt ctgaaagggc
781 aatccggacc cagcccaagc aactgattgt ggatgacttg aagggttcct tgaaagagga
841 cctgacacag cacaagttca tttgtgaaca gtgtgggaag tgcaagtgtg gagaatgcac
901 tgctcccagg accctaccat cctgtttggc ctgtaaccgg cagtgccttt gctctgctga
961 gagcatggtg gaatatggaa cctgcatgtg cttagtcaag ggcatcttct accactgctc
1021 caatgacgac gaaggggatt cctattcaga taatccttgc tcctgttcac aatcacactg
1081 ctgctctaga tacctgtgta tgggagccat gtctttattt ttaccttgct tactctgtta
1141 tcctcctgct aaaggatgcc tgaagctgtg caggaggtgt tatgactgga tccatcgccc
1201 agggtgcaga tgtaagaact ccaacactgt ctattgtaag ctggagagct gcccctcccg
1261 gggtcagggt aaaccatcat gatttttgga ggtgggttgt acctcctgaa cttttagctt
1321 tcaagttgtg gctgtttttt gtttttgttt ttgtttttgt tttctttaga atttttccct
1381 gtttcccacc ttctcttccc ctgttgccaa ggtctaactc atggattttt ctctttcctc
1441 atggatgatc ttcagcaaga gtggactggg aagctgcacc tggctcccac tttcaacaag
1501 agcctctgcc atccacttga gggtattgag agccagtggg cttttgtgta gcctttttgt
1561 tctgcaagca actttctaaa gttgtgtaca tgaacataca cccacatcca gactacagtg
1621 atttagagtt gttttgattg ggtaccgtgg gagcagggaa attggttttt taaaaagcaa
1681 ctgtttaatt gcttaaataa gctatgtatt aaatctgtct ccagttaggg ctatcttcct
1741 agcataggcc ccttaagtag catgggggat atattttttg ctataacgta aaaattttcc
1801 tttaaccact gccctctcct tctttctcct tcaaggttct ttccccctca gttttgttgt
1861 tgtcttactc tggagatgcc aagtgtattt tttctttcta tgtaatttta gattcgcctt
1921 acaatgtaaa tcttcacatt ggagataata ttggttggac cttgcccatc ttcactctag
1981 ccttcgtatt tgtgaaggac tcagccacct tccttcttca ccccatgctt ctcaccaaat
2041 ttttgttgtc attgagggca cttggataac tcaagttgat atttatagct gatcaatcta
2101 tatgtgtcac agaactatgc tgcctaaagt gatcttggct ccttaatggt ccttttggcc
2161 ccttggatag ttaacagctg agtaattcta atctcttctg tgttttcctt gccttaacca
2221 caaattgtgg tgctttttgt atattttatg tataaatcac aaagttgaat tctgactatt
2281 tttaagacaa aagtctgtta aactttttta ttgtaaagaa tatttattat gcgaatctct
2341 attattttat ggtatttatt gcaaaagact gttgaaatgt actcatgttt gaatataaca
2401 aaatatcaat acttaacgga aaataaggtg acacgaagaa agtacatatg ttaactataa
2461 tgcagaaaat atattaatta atgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2581 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
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