LOCUS BC063304 4246 bp mRNA linear HUM 17-JUL-2006
DEFINITION Homo sapiens natriuretic peptide receptor A/guanylate cyclase A
(atrionatriuretic peptide receptor A), mRNA (cDNA clone MGC:71716
IMAGE:30331757), complete cds.
ACCESSION BC063304
VERSION BC063304.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4246)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4246)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-DEC-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. Stefan Hansson
cDNA Library Preparation: Michael Brownstein / Ted Usdin
Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 133 Row: a Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 40254425.
FEATURES Location/Qualifiers
source 1..4246
/db_xref="H-InvDB:HIT000260825"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:71716 IMAGE:30331757"
/tissue_type="Placenta, pre-eclamptic"
/clone_lib="NIH_MGC_148"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4246
/gene="NPR1"
/gene_synonym="ANPa"
/gene_synonym="GUC2A"
/gene_synonym="GUCY2A"
/db_xref="GeneID:4881"
/db_xref="HGNC:HGNC:7943"
/db_xref="MIM:108960"
CDS 471..3656
/gene="NPR1"
/gene_synonym="ANPa"
/gene_synonym="GUC2A"
/gene_synonym="GUCY2A"
/codon_start=1
/product="natriuretic peptide receptor A/guanylate cyclase
A (atrionatriuretic peptide receptor A)"
/protein_id="AAH63304.1"
/db_xref="GeneID:4881"
/db_xref="HGNC:HGNC:7943"
/db_xref="MIM:108960"
/translation="MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLA
NTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAV
DLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGP
SYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHL
EFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIF
GQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAY
EQFNFTMEDVLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGV
TGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPP
DIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELW
RVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAV
KRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDIL
ENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLE
SFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFH
VEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIR
LTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHS
VAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDN
FDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLR
IGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGF
ELELRGDVEMKGKGKVRTYWLLGERGSSTRG"
BASE COUNT 846 a 1313 c 1270 g 817 t
ORIGIN
1 ggttccctcc ggatagccgg agacttgggc cggccggacg ccccttctgg cacactccct
61 ggggcaggcg ctcacgcacg ctacaaacac acactcctct ttcctccctc gcgcgccctc
121 tctcatcctt cttcacgaag cgctcactcg caccctttct ctctctctct ctctctctaa
181 cacgcacgca cactcccagt tgttcacact cgggtcctct ccagcccgac gttctcctgg
241 cacccacctg ctccgcggcg ccctgcgcgc ccccctcggt cgcgcccctt gcgctctcgg
301 cccagaccgt cgcagctaca gggggcctcg agccccgggg tgagcgtccc cgtcccgctc
361 ctgctccttc ccatagggac gcgcctgatg cctgggaccg gccgctgagc ccaaggggac
421 cgaggaggcc atggtaggag cgctcgcctg ctgcggtgcc cgctgaggcc atgccggggc
481 cccggcgccc cgctggctcc cgcctgcgcc tgctcctgct cctgctgctg ccgccgctgc
541 tgctgctgct ccggggcagc cacgcgggca acctgacggt agccgtggta ctgccgctgg
601 ccaatacctc gtacccctgg tcgtgggcgc gcgtgggacc cgccgtggag ctggccctgg
661 cccaggtgaa ggcgcgcccc gacttgctgc cgggctggac ggtccgcacg gtgctgggca
721 gcagcgaaaa cgcgctgggc gtctgctccg acaccgcagc gcccctggcc gcggtggacc
781 tcaagtggga gcacaacccc gctgtgttcc tgggccccgg ctgcgtgtac gccgccgccc
841 cagtggggcg cttcaccgcg cactggcggg tcccgctgct gaccgccggc gccccggcgc
901 tgggcttcgg tgtcaaggac gagtatgcgc tgaccacccg cgcggggccc agctacgcca
961 agctggggga cttcgtggcg gcgctgcacc gacggctggg ctgggagcgc caagcgctca
1021 tgctctacgc ctaccggccg ggtgacgaag agcactgctt cttcctcgtg gaggggctgt
1081 tcatgcgggt ccgcgaccgc ctcaatatta cggtggacca cctggagttc gccgaggacg
1141 acctcagcca ctacaccagg ctgctgcgga ccatgccgcg caaaggccga gttatctaca
1201 tctgcagctc ccctgatgcc ttcagaaccc tcatgctcct ggccctggaa gctggcttgt
1261 gtggggagga ctacgttttc ttccacctgg atatctttgg gcaaagcctg caaggtggac
1321 agggccctgc tccccgcagg ccctgggaga gaggggatgg gcaggatgtc agtgcccgcc
1381 aggcctttca ggctgccaaa atcattacat ataaagaccc agataatccc gagtacttgg
1441 aattcctgaa gcagttaaaa cacctggcct atgagcagtt caacttcacc atggaggatg
1501 tcctggtgaa caccatccca gcatccttcc acgacgggct cctgctctat atccaggcag
1561 tgacggagac tctggcacat gggggaactg ttactgatgg ggagaacatc actcagcgga
1621 tgtggaaccg aagctttcaa ggtgtgacag gatacctgaa aattgatagc agtggcgatc
1681 gggaaacaga cttctccctc tgggatatgg atcccgagaa tggtgccttc agggttgtac
1741 tgaactacaa tgggacttcc caagagctgg tggctgtgtc ggggcgcaaa ctgaactggc
1801 ccctggggta ccctcctcct gacatcccca aatgtggctt tgacaacgaa gacccagcat
1861 gcaaccaaga tcacctttcc accctggagg tgctggcttt ggtgggcagc ctctccttgc
1921 tcggcattct gattgtctcc ttcttcatat acaggaagat gcagctggag aaggaactgg
1981 cctcggagct gtggcgggtg cgctgggagg acgttgagcc cagtagcctt gagaggcacc
2041 tgcggagtgc aggcagccgg ctgaccctga gcgggagagg ctccaattac ggctccctgc
2101 taaccacaga gggccagttc caagtctttg ccaagacagc atattataag ggcaacctcg
2161 tggctgtgaa acgtgtgaac cgtaaacgca ttgagctgac acgaaaagtc ctgtttgaac
2221 tgaagcatat gcgggatgtg cagaatgaac acctgaccag gtttgtggga gcctgcaccg
2281 acccccccaa tatctgcatc ctcacagagt actgtccccg tgggagcctg caggacattc
2341 tggagaatga gagcatcacc ctggactgga tgttccggta ctcactcacc aatgacatcg
2401 tcaagggcat gctgtttcta cacaatgggg ctatctgttc ccatgggaac ctcaagtcat
2461 ccaactgcgt ggtagatggg cgctttgtgc tcaagatcac cgactatggg ctggagagct
2521 tcagggacct ggacccagag caaggacaca ccgtttatgc caaaaagctg tggacggccc
2581 ctgagctcct gcgaatggct tcaccccctg tgcggggctc ccaggctggt gacgtataca
2641 gctttgggat catccttcag gagattgccc tgaggagtgg ggtcttccac gtggaaggtt
2701 tggacctgag ccccaaagag atcatcgagc gggtgactcg gggtgagcag ccccccttcc
2761 ggccctccct ggccctgcag agtcacctgg aggagttggg gctgctcatg cagcggtgct
2821 gggctgagga cccacaggag aggccaccat tccagcagat ccgcctgacg ttgcgcaaat
2881 ttaacaggga gaacagcagc aacatcctgg acaacctgct gtcccgcatg gagcagtacg
2941 cgaacaatct ggaggaactg gtggaggagc ggacccaggc atacctggag gagaagcgca
3001 aggctgaggc cctgctctac cagatcctgc ctcactcagt ggctgagcag ctgaagcgtg
3061 gggagacggt gcaggccgaa gcctttgaca gtgttaccat ctacttcagt gacattgtgg
3121 gtttcacagc gctgtcggcg gagagcacgc ccatgcaggt ggtgaccctg ctcaatgacc
3181 tgtacacttg ctttgatgct gtcatagaca actttgatgt gtacaaggtg gagacaattg
3241 gcgatgccta catggtggtg tcagggctcc ctgtgcggaa cgggcggcta cacgcctgcg
3301 aggtagcccg catggccctg gcactgctgg atgctgtgcg ctccttccga atccgccacc
3361 ggccccagga gcagctgcgc ttgcgcattg gcatccacac aggacctgtg tgtgctggag
3421 tggtgggact gaagatgccc cgttactgtc tctttgggga tacagtcaac acagcctcaa
3481 gaatggagtc taatggggaa gccctgaaga tccacttgtc ttctgagacc aaggctgtcc
3541 tggaggagtt tggtggtttc gagctggagc ttcgagggga tgtagaaatg aagggcaaag
3601 gcaaggttcg gacctactgg ctccttgggg agagggggag tagcacccga ggctgacctg
3661 cctcctctcc tatccctcca cacctcccct accctgtgcc agaagcaaca gaggtgccag
3721 gcctcagcct cacccacagc agccccatcg ccaaaggatg gaagtaattt gaatagctca
3781 ggtgtgctta ccccagtgaa gacaccagat aggacctctg agaggggact ggcatggggg
3841 gatctcagag cttacaggct gagccaagcc cacggccatg cacagggaca ctcacacagg
3901 cacacgcacc tgctctccac ctggactcag gccgggctgg gctgtggatt cctgatcccc
3961 tcccctcccc atgctctcct ccctcagcct tgctaccctg tgacttactg ggaggagaaa
4021 gagtcacctg aaggggaaca tgaaaagaga ctaggtgaag agagggcagg ggagcccaca
4081 tctggggctg gcccacaata cctgctcccc cgaccccctc cacccagcag tagacacagt
4141 gcacagggga gaagaggggt ggcgcagaag ggttgggggc ctgtatgcct tgcttctacc
4201 atgagcagag acaattaaaa tctttattcc aaaaaaaaaa aaaaaa
//