LOCUS BC062580 2655 bp mRNA linear HUM 28-NOV-2003
DEFINITION Homo sapiens neurotrophic tyrosine kinase, receptor, type 1, mRNA
(cDNA clone IMAGE:5200930), partial cds.
ACCESSION BC062580
VERSION BC062580.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2655)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2655)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (24-NOV-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 135 Row: g Column: 13
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4585711.
FEATURES Location/Qualifiers
source 1..2655
/db_xref="H-InvDB:HIT000260492"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:5200930"
/tissue_type="Brain, adult, 6 pooled whole brains"
/clone_lib="NIH_MGC_114"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..2655
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="TRK"
/gene_synonym="TRKA"
/db_xref="GeneID:4914"
/db_xref="MIM:191315"
CDS <1..2390
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="TRK"
/gene_synonym="TRKA"
/codon_start=3
/product="NTRK1 protein"
/protein_id="AAH62580.1"
/db_xref="GeneID:4914"
/db_xref="MIM:191315"
/translation="LRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGS
SGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGL
RFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQR
WEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEG
RGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVS
VQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEP
AANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPV
SFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGIN
RPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRD
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTML
QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLG
QLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV
GGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT
QGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG"
misc_feature 441..560
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="TRK"
/gene_synonym="TRKA"
/note="LRRCT; Region: Leucine rich repeat C-terminal
domain. Leucine Rich Repeats pfam00560 are short sequence
motifs present in a number of proteins with diverse
functions and cellular locations. Leucine Rich Repeats are
often flanked by cysteine rich domains. This domain is
often found at the C-terminus of tandem leucine rich
repeats"
/db_xref="CDD:pfam01463"
misc_feature 600..848
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="TRK"
/gene_synonym="TRKA"
/note="IG; Region: Immunoglobulin"
/db_xref="CDD:smart00409"
misc_feature 909..1121
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="TRK"
/gene_synonym="TRKA"
/note="IGcam; Region: Immunoglobulin domain cell adhesion
molecule (cam) subfamily"
/db_xref="CDD:cd00931"
misc_feature 1509..2351
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="TRK"
/gene_synonym="TRKA"
/note="TyrKc; Region: Tyrosine kinase, catalytic domain.
Phosphotransferases"
/db_xref="CDD:cd00192"
BASE COUNT 518 a 799 c 820 g 518 t
ORIGIN
1 tgctgcgagg cggacggcgc gggcagcttg gctggcacag ctgggctgcg gggccgggca
61 gcctgctggc ttggctgata ctggcatctg cgggcgccgc accctgcccc gatgcctgct
121 gcccccacgg ctcctcggga ctgcgatgca cccgggatgg ggccctggat agcctccacc
181 acctgcccgg cgcagagaac ctgactgagc tctacatcga gaaccagcag catctgcagc
241 atctggagct ccgtgatctg aggggcctgg gggagctgag aaacctcacc atcgtgaaga
301 gtggtctccg tttcgtggcg ccagatgcct tccatttcac tcctcggctc agtcgcctga
361 atctctcctt caacgctctg gagtctctct cctggaaaac tgtgcagggc ctctccttac
421 aggaactggt cctgtcgggg aaccctctgc actgttcttg tgccctgcgc tggctacagc
481 gctgggagga ggagggactg ggcggagtgc ctgaacagaa gctgcagtgt catgggcaag
541 ggcccctggc ccacatgccc aatgccagct gtggtgtgcc cacgctgaag gtccaggtgc
601 ccaatgcctc ggtggatgtg ggggacgacg tgctgctgcg gtgccaggtg gaggggcggg
661 gcctggagca ggccggctgg atcctcacag agctggagca gtcagccacg gtgatgaaat
721 ctgggggtct gccatccctg gggctgaccc tggccaatgt caccagtgac ctcaacagga
781 agaacgtgac gtgctgggca gagaacgatg tgggccgggc agaggtctct gttcaggtca
841 acgtctcctt cccggccagt gtgcagctgc acacggcggt ggagatgcac cactggtgca
901 tccccttctc tgtggatggg cagccggcac cgtctctgcg ctggctcttc aatggctccg
961 tgctcaatga gaccagcttc atcttcactg agttcctgga gccggcagcc aatgagaccg
1021 tgcggcacgg gtgtctgcgc ctcaaccagc ccacccacgt caacaacggc aactacacgc
1081 tgctggctgc caaccccttc ggccaggcct ccgcctccat catggctgcc ttcatggaca
1141 accctttcga gttcaacccc gaggacccca tccctgtctc cttctcgccg gtggacacta
1201 acagcacatc tggagacccg gtggagaaga aggacgaaac accttttggg gtctcggtgg
1261 ctgtgggcct ggccgtcttt gcctgcctct tcctttctac gctgctcctt gtgctcaaca
1321 aatgtggacg gagaaacaag tttgggatca accgcccggc tgtgctggct ccagaggatg
1381 ggctggccat gtccctgcat ttcatgacat tgggtggcag ctccctgtcc cccaccgagg
1441 gcaaaggctc tgggctccaa ggccacatca tcgagaaccc acaatacttc agtgatgcct
1501 gtgttcacca catcaagcgc cgggacatcg tgctcaagtg ggagctgggg gagggcgcct
1561 ttgggaaggt cttccttgct gagtgccaca acctcctgcc tgagcaggac aagatgctgg
1621 tggctgtcaa ggcactgaag gaggcgtccg agagtgctcg gcaggacttc cagcgtgagg
1681 ctgagctgct caccatgctg cagcaccagc acatcgtgcg cttcttcggc gtctgcaccg
1741 agggccgccc cctgctcatg gtctttgagt atatgcggca cggggacctc aaccgcttcc
1801 tccgatccca tggacctgat gccaagctgc tggctggtgg ggaggatgtg gctccaggcc
1861 ccctgggtct ggggcagctg ctggccgtgg ctagccaggt cgctgcgggg atggtgtacc
1921 tggcgggtct gcattttgtg caccgggacc tggccacacg caactgtcta gtgggccagg
1981 gactggtggt caagattggt gattttggca tgagcaggga tatctacagc accgactatt
2041 accgtgtggg aggccgcacc atgctgccca ttcgctggat gccgcccgag agcatcctgt
2101 accgtaagtt caccaccgag agcgacgtgt ggagcttcgg cgtggtgctc tgggagatct
2161 tcacctacgg caagcagccc tggtaccagc tctccaacac ggaggcaatc gactgcatca
2221 cgcagggacg tgagttggag cggccacgtg cctgcccacc agaggtctac gccatcatgc
2281 ggggctgctg gcagcgggag ccccagcaac gccacagcat caaggatgtg cacgcccggc
2341 tgcaagccct ggcccaggca cctcctgtct acctggatgt cctgggctag ggggccggcc
2401 caggggctgg gagtggttag ccggaatact ggggcctgcc ctcagcatcc cccatagctc
2461 ccagcagccc cagggtgatc ttaaagtatc taattcaccc tcagcatgtg ggaagggaca
2521 ggtgggggct gggagtagag gatgttcctg cttctctagg caaggtcccg tcatagcaat
2581 tatatttatt atcccttgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2641 aaaaaaaaaa aaaaa
//