LOCUS BC062417 1411 bp mRNA linear HUM 16-DEC-2003
DEFINITION Homo sapiens Rho GTPase activating protein 18, mRNA (cDNA clone
IMAGE:6514579), partial cds.
ACCESSION BC062417
VERSION BC062417.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1411)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1411)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (17-NOV-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 141 Row: k Column: 14
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15723375.
FEATURES Location/Qualifiers
source 1..1411
/db_xref="H-InvDB:HIT000260380"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:6514579"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_71"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..>1411
/gene="ARHGAP18"
/gene_synonym="bA307O14.2"
/gene_synonym="MacGAP"
/db_xref="GeneID:93663"
CDS <1..>1411
/gene="ARHGAP18"
/gene_synonym="bA307O14.2"
/gene_synonym="MacGAP"
/codon_start=2
/product="ARHGAP18 protein"
/protein_id="AAH62417.1"
/db_xref="GeneID:93663"
/translation="SWLSSSQGVVLTAYHPSGKDQAVGNSHAKAGEEATSSRRYGQYT
MNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKE
PDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRK
KNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIP
PEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIG
DLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQR
KVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWES
VKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANR
DTLKALLEFLQRVIDKKKKK"
misc_feature 1025..1408
/gene="ARHGAP18"
/gene_synonym="bA307O14.2"
/gene_synonym="MacGAP"
/note="RhoGAP; Region: RhoGAP domain. GTPase activator
proteins towards Rho/Rac/Cdc42-like small GTPases"
/db_xref="CDD:pfam00620"
BASE COUNT 472 a 312 c 332 g 295 t
ORIGIN
1 gagctggctc tccagttccc agggagtggt actaacagcc taccacccca gcggcaagga
61 ccaggccgtc gggaacagcc atgcaaaggc aggggaggaa gccacctcga gtcgcagata
121 tggccagtac actatgaacc aggaaagcac caccatcaaa gttatggaga agcctccatt
181 tgatcgatca atttcccagg attctttgga tgaactatct atggaagact attggataga
241 actagaaaac atcaagaaat ctagtgaaaa cagccaagaa gatcaagagg tggttgttgt
301 caaagagcct gatgagggag aattggaaga agagtggctt aaagaggccg gtttatccaa
361 tctcttcgga gagtctgctg gagatccaca ggaaagcatt gtgtttttat caacattgac
421 gcggacccag gcagcagcag ttcagaagcg agtagagacg gtctcccaga ccttgaggaa
481 aaaaaacaaa cagtaccaga ttcctgacgt cagagacata tttgctcaac agagagaatc
541 aaaagaaaca gctccaggtg gcactgaatc gcagtcactt agaacaaatg aaaacaaata
601 ccaaggaaga gatgacgagg catctaacct tgttggtgaa gagaagctga tcccacctga
661 ggagacgcct gcccctgaaa cagacatcaa cctggaggta tcatttgccg agcaagcact
721 caatcagaaa gagagctcca aggagaaaat ccagaagagc aaaggcgatg atgccacatt
781 acctagtttc agattgccaa aagacaaaac gggtaccaca aggattggtg acctcgcacc
841 ccaggacatg aagaaagttt gccatttagc cctaattgag ctgactgccc tctatgatgt
901 attgggtatt gagctgaaac aacaaaaagc tgtgaaaatc aaaacaaaag attctggtct
961 tttttgcgtt ccattgacag cgctattaga acaagatcag aggaaagtac caggaatgcg
1021 aatacccttg atctttcaaa aactgatttc tcgaattgaa gagagaggtt tggaaacaga
1081 aggcctctta cggatccctg gagctgccat tagaatcaag aatctttgcc aagaactaga
1141 agcaaagttt tatgaaggga cttttaattg ggaaagtgtc aaacagcatg atgccgccag
1201 cctgctgaag ctcttcattc gggagttgcc ccagccactg ctcagtgtgg agtatctcaa
1261 agcctttcag gctgtccaga atcttccaac caagaagcag caactacagg ctttgaacct
1321 tcttgtcatc ctcctacctg atgcaaacag ggacacactg aaggcccttc ttgaatttct
1381 ccaaagagta atagataaaa aaaaaaaaaa a
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