LOCUS BC062327 1090 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens caspase 1, apoptosis-related cysteine peptidase
(interleukin 1, beta, convertase), mRNA (cDNA clone MGC:71185
IMAGE:5477096), complete cds.
ACCESSION BC062327
VERSION BC062327.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1090)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1090)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (17-NOV-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 50 Row: i Column: 2
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15431331.
FEATURES Location/Qualifiers
source 1..1090
/db_xref="H-InvDB:HIT000260328"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:71185 IMAGE:5477096"
/tissue_type="Brain, astrocytoma, grade IV"
/clone_lib="NIH_MGC_98"
/lab_host="DH10B"
/note="Vector: pOTB7"
gene 1..1090
/gene="CASP1"
/gene_synonym="ICE"
/gene_synonym="P45"
/db_xref="GeneID:834"
/db_xref="HGNC:HGNC:1499"
/db_xref="MIM:147678"
CDS 11..946
/gene="CASP1"
/gene_synonym="ICE"
/gene_synonym="P45"
/codon_start=1
/product="caspase 1, apoptosis-related cysteine peptidase
(interleukin 1, beta, convertase)"
/protein_id="AAH62327.1"
/db_xref="GeneID:834"
/db_xref="HGNC:HGNC:1499"
/db_xref="MIM:147678"
/translation="MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCS
LEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQN
LGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVP
DILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTE
EFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEI
FRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH"
BASE COUNT 350 a 217 c 252 g 271 t
ORIGIN
1 gagaaaagcc atggccgaca aggtcctgaa ggagaagaga aagctgttta tccgttccat
61 gggtgaagct cctcaggcag tgcaggacaa cccagctatg cccacatcct caggctcaga
121 agggaatgtc aagctttgct ccctagaaga agctcaaagg atatggaaac aaaagtcggc
181 agagatttat ccaataatgg acaagtcaag ccgcacacgt cttgctctca ttatctgcaa
241 tgaagaattt gacagtattc ctagaagaac tggagctgag gttgacatca caggcatgac
301 aatgctgcta caaaatctgg ggtacagcgt agatgtgaaa aaaaatctca ctgcttcgga
361 catgactaca gagctggagg catttgcaca ccgcccagag cacaagacct ctgacagcac
421 gttcctggtg ttcatgtctc atggtattcg ggaaggcatt tgtgggaaga aacactctga
481 gcaagtccca gatatactac aactcaatgc aatctttaac atgttgaata ccaagaactg
541 cccaagtttg aaggacaaac cgaaggtgat catcatccag gcctgccgtg gtgacagccc
601 tggtgtggtg tggtttaaag attcagtagg agtttctgga aacctatctt taccaactac
661 agaagagttt gaggatgatg ctattaagaa agcccacata gagaaggatt ttatcgcttt
721 ctgctcttcc acaccagata atgtttcttg gagacatccc acaatgggct ctgtttttat
781 tggaagactc attgaacata tgcaagaata tgcctgttcc tgtgatgtgg aggaaatttt
841 ccgcaaggtt cgattttcat ttgagcagcc agatggtaga gcgcagatgc ccaccactga
901 aagagtgact ttgacaagat gtttctacct cttcccagga cattaaaata aggaaactgt
961 atgaatgtct gtgggcagga agtgaagaga tccttctgta aaggtttttg gaattatgtc
1021 tgctgaataa taaacttttt tgaaataata aatctggtag aaaaatgaaa aaaaaaaaaa
1081 aaaaaaaaaa
//