LOCUS BC057394 6904 bp mRNA linear HUM 24-JUL-2018
DEFINITION Homo sapiens Rho guanine nucleotide exchange factor (GEF) 11, mRNA
(cDNA clone MGC:60344 IMAGE:6148684), complete cds.
ACCESSION BC057394
VERSION BC057394.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6904)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 6904)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (03-SEP-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
REFERENCE 3 (bases 1 to 6904)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (24-JUL-2018) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK Sequence update by database staff to remove vector contamination
COMMENT On Jul 24, 2018 this sequence version replaced BC057394.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 110 Row: k Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 38026933.
FEATURES Location/Qualifiers
source 1..6904
/db_xref="H-InvDB:HIT000259693"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:60344 IMAGE:6148684"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_72"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..6904
/gene="ARHGEF11"
/gene_synonym="GTRAP48"
/gene_synonym="KIAA0380"
/gene_synonym="PDZ-RHOGEF"
/db_xref="GeneID:9826"
/db_xref="HGNC:HGNC:14580"
/db_xref="MIM:605708"
CDS 1041..5729
/gene="ARHGEF11"
/gene_synonym="GTRAP48"
/gene_synonym="KIAA0380"
/gene_synonym="PDZ-RHOGEF"
/codon_start=1
/product="Rho guanine nucleotide exchange factor (GEF) 11"
/protein_id="AAH57394.1"
/db_xref="GeneID:9826"
/db_xref="HGNC:HGNC:14580"
/db_xref="MIM:605708"
/translation="MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLV
QRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSH
LEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPP
QRITGPKPLQDPEVQKHATQILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRR
VTQLQLKIQQETGGSVDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSES
LMNRNSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGP
EEDYDPGYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQA
SPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMP
EIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDR
SAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKD
ALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPG
TQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAA
AEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDD
LGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDL
IFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLAR
FDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDL
IISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHR
LEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLE
DLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICT
SKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQG
PTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVL
PCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTM
ETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM
GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALP
ESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEP
QPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLG
GESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDS
TADAAASPGP"
BASE COUNT 1717 a 1883 c 1777 g 1527 t
ORIGIN
1 agcgaaatct ccgtttcatg gaggctgagg caagagaaaa tttcggagcc tggatgtgga
61 ggagcccaac agcagaacta actcaggaaa ttgtctttca gaaaaaggcc gaacgtaggc
121 tgggtctgag aatcaggctg gggtaggtgg aggaacctgc aagtttaaag gaaaaagaaa
181 aggagagaat attttcagtg attatctctg gtttgttatc attactacca tcttaaaggt
241 aaaaagcatt gcatttcagg tgttctttga tttttatttt attttttttt ttggtgcaat
301 tggctcattt aagaatttca aaacatttaa tgtaaaagct tttttttttt taaggaagtc
361 cataaatttt ggttcccagg gttgcactgg acttggaagg agtgctgttg tgtacatact
421 attgtatggt tttatttatt attttactgt acaaatcagc tgaaagaatt tttccaagtg
481 ccatttcgga tttattaatc cttttttttt tcctttcctc aaagatattt gctgttgtca
541 tattaagcat tggagactag aaaattactt tccccctttg agctagaggg tctcttgcca
601 acagaaggac agctgagaaa gctggattta aaggatggtt ttatctgtac tttgcagtta
661 acagtgatat tttgaaggca catttttctg tgattcattt ttttttggcc atagtgctaa
721 ccttgaagag attcgtggct gggtttttgg tttctgagaa ggtcgtagtt tttcctcttt
781 tccttttttt ttcttttttc ttttcttttc ttttttttta aagcggggga ggggaagagg
841 ggctgagaaa ggaaatcatg ttcactggta gaagtagagt ggagcatcag ttaccagggt
901 cctgagagct ggaggagaaa ggattctatc ttcaagttgg gaggccctcc tctcaccttg
961 ctcaaaaatt gcaagcgatt caatcctgat caagacacca aagctacagg attctggaac
1021 cgtggagaca ccgagaaacc atgagtgtaa ggttacccca gagtatagac aggttaagta
1081 gcctgtcttc tctgggagat tctgcaccag agcgcaagtc cccttcccac catcgccagc
1141 cttcggatgc ctctgagaca acaggtctcg ttcaacgctg tgtcattatc caaaaggacc
1201 agcatggctt cggcttcaca gtcagtgggg atcgcattgt tctggtgcag tctgtgcggc
1261 ctggaggtgc agccatgaag gccggtgtga aagagggcga ccggatcatc aaagtcaacg
1321 gcaccatggt gaccaatagc tcacacctgg aagtggtaaa gctgatcaaa tctggcgcct
1381 atgtcgcact caccctcctg ggctcttcac cttcatccat gggcatctct gggctccagc
1441 aggacccatc cccagcagga gctccccgaa tcacgtcagt gatcccctca ccaccacctc
1501 ctccacctct accacctcca caacgcatca caggacccaa acctctgcag gatcccgaag
1561 ttcaaaaaca tgccacccag atcctcagga atatgctgag gcaggaagaa aaagaattac
1621 agcgtatctg tgaggtctat agccggaacc ccgccagcct actggaagag cagatcgaag
1681 gtgcccggcg gcgagtcact cagttacagc tgaagatcca gcaggagact ggtggctcag
1741 tggacatact tccactatat ggtgacacca gccagagacc atcagaaggc cggctctctc
1801 tggattccca ggagggggac agtggcttgg actctgggac agaacgcttt ccttccctca
1861 gtgagtcatt gatgaatcgg aactcggtac tgtcagaccc tgggctagac agtcctcgaa
1921 cctcccctgt gatcatggcc agggtggccc agcaccacag gcggcagggc tcggatgcag
1981 cagtcccctc aaccggtgac cagggtgtag atcaaagccc aaagccttta attattggcc
2041 cagaggaaga ctatgacccg ggttatttca acaacgagag cgacatcata ttccaggatc
2101 tggagaaact gaagtctcgg ccagctcacc tgggggtttt tctacgttac atcttctctc
2161 aggcggaccc cagtccactg cttttttacc tgtgtgcaga agtttatcag caggcaagcc
2221 ccaaggattc ccgaagcttg gggaaagaca tctggaatat tttcctggag aaaaatgcgc
2281 ctctgagagt gaagatccct gagatgctac aggctgaaat tgactcgcgc ctgcggaaca
2341 gcgaagatgc ccgtggtgtt ctctgtgaag ctcaagaggc agccatgcct gagatccaag
2401 agcagatcca cgactacaga acgaagcgca cactggggct gggcagcctg tatggtgaaa
2461 atgacctgct ggacctggat ggggaccctc tccgagagcg ccaagtggct gagaagcagc
2521 tggctgccct tggagatatt ttgtccaagt atgaggaaga caggagcgcc cccatggact
2581 tcgccctcaa tacctacatg agccatgctg ggatccgtct tcgagaggca cgaccttcca
2641 acacagctga aaaggcccag tctgctcctg acaaggacaa gtggctaccg ttcttcccta
2701 agaccaagaa gagcagcaat tccaagaaag aaaaggatgc cttggaggac aagaagcgaa
2761 accctatcct caaatacatt gggaagccca aaagctcttc tcaaagcaca tttcatattc
2821 ccttgtcccc tgtggaagtc aaaccaggca atgtgaggaa catcattcag cactttgaga
2881 acaaccagca gtatgatgcc ccagaacctg ggacacaacg actctcgacc ggaagctttc
2941 ctgaggacct gctggagagt gacagttcac gctcagagat tcgcctgggc cgctctgaaa
3001 gcctcaaggg ccgggaagag atgaaacggt ctcgaaaggc agagaacgtg ccccgctctc
3061 gcagtgatgt tgacatggat gctgctgcgg aggctactcg cctgcaccag tcagcctcgt
3121 cctctacctc cagcctctcc accaggtctc ttgagaaccc aacccctcca ttcactccca
3181 aaatgggccg caggagcatt gagtccccca gtttggggtt ctgcacagat accctccttc
3241 cccacctcct agaggatgat ctgggccagc tgtctgacct ggagccagag ccagatgccc
3301 aaaattggca gcatacagtg ggcaaggatg tggtggctgg gctaacccag cgggagattg
3361 accggcaaga ggtcatcaat gagctgtttg tgactgaagc ttcccacctg cgcacactcc
3421 gggtcctgga cctgatcttc taccagcgaa tgaagaagga gaacctgatg ccccgggagg
3481 agctggcccg gctcttcccg aacctgcctg aactcataga gattcacaat tcctggtgtg
3541 aagccatgaa gaagctccgg gaggaaggcc ccatcatcaa agagatcagt gacctcatgc
3601 tggcccggtt tgatggccct gcccgagagg aactccagca agtggctgca cagttctgtt
3661 cctatcagtc aatagcccta gagctaatca agaccaagca acgcaaggag agtcgattcc
3721 agctcttcat gcaggaggct gagagccacc ctcagtgtcg gcggctgcag ctgagagacc
3781 tcatcatctc tgagatgcag cggctcacca agtacccgct gctgctggag agcatcatca
3841 agcacacaga gggtggcacc tctgagcatg agaagctgtg ccgggcccgg gaccagtgcc
3901 gggagattct caagtatgtg aatgaagcgg taaaacaaac agagaaccgc caccgtttag
3961 agggctacca gaaacgcctg gatgccaccg ccctggagag ggccagcaac cccctggcag
4021 cagagttcaa gagcctggat cttacaacca gaaaaatgat ccatgaggga cccctgacct
4081 ggaggatcag caaggataag accttggacc tccacgtgct gctgctggag gacctcctag
4141 tgctgctaca gaaacaggat gagaagctat tgctgaagtg ccacagcaag actgctgtgg
4201 gctcctcaga cagcaagcag accttcagcc ccgtgctcaa gctcaatgct gtgctcatcc
4261 gctctgtggc cacagataaa cgggccttct tcatcatctg cacctccaag ctgggcccac
4321 cccagatcta tgagctggtt gcattgacgt catcagacaa gaacacatgg atggagctct
4381 tagaagaggc cgtgcggaat gccaccaggc accccggagc tgccccaatg cccgtccatc
4441 ctccaccccc aggtccccgg gagccagccc agcagggccc cacacccagc agggtagaac
4501 tggatgactc agacgtgttc catggtgaac ctgaacctga ggagctgcct ggaggcactg
4561 ggtcccagca gagggtccaa gggaagcacc aggtcctgct agaggaccct gagcaggagg
4621 gcagtgcaga ggaagaggaa ctgggtgtcc tgccttgccc ttccacatcc ctggatggag
4681 agaacagggg catcaggaca aggaacccca tccacttggc cttcccaggc cctctgttca
4741 tggaagggct cgctgactcc gctctggaag atgtggagaa cctgcgacat ctgatcctgt
4801 ggagcctgct gccaggtcac accatggaaa ctcaggctgc ccaggagccc gaggacgacc
4861 tgacacccac accttctgtc atcagcgtca cctctcaccc ctgggaccca ggctccccag
4921 ggcaagcacc ccctgggggt gaaggggaca acacccagct tgcagggctg gagggggaac
4981 ggccagagca ggaagacatg ggtctctgtt ctctggaaca cctaccccca aggaccagaa
5041 attctgggat atgggagtct ccagaactgg acaggaatct ggctgaagat gcttcaagca
5101 cagaggcagc aggaggttac aaagttgtga gaaaagctga ggtggcaggc agcaaggttg
5161 tccctgcact accagagagt ggccagtcag agcctgggcc acctgaagtg gaaggcggaa
5221 caaaggctac ggggaactgc ttttatgtca gcatgccatc aggacccccg gactcaagca
5281 ccgaccactc agaggcaccc atgagccccc ctcagcctga cagcctccct gcagggcaga
5341 cagagcctca gcctcagctg cagggaggca acgatgatcc aagacgcccc agccgctctc
5401 ctccaagcct ggccctcagg gacgtgggca tgatcttcca taccattgag cagctcactc
5461 tcaagctcaa caggctcaag gatatggagc tggcccacag agagctgctc aagtcccttg
5521 ggggagagtc atctggtggc accacgcctg tgggcagttt ccacacagaa gcagctagat
5581 ggacagatgg ctccctctca cctcccgcta aggagcccct agcttctgac tccaggaaca
5641 gccatgaact ggggccctgc cctgaggatg gctctgacgc ccccctggaa gacagcacag
5701 cagacgcagc cgcgtcacca ggaccataac cgtacaaacc accaaatcct ctgcgtcccc
5761 actcctcctt cagggactgg cctgagaccg gggcacaggg taggggggat cccaacactc
5821 ctccctgtgg aggaggcagt tagggaaact aggatccagc caaggcccgg ggggagaccc
5881 gcatgttgct tggtctgctc aagtcggagt caggtttcag tgtcttttcc ctcccttagc
5941 ccaaccctcc aaggcctcat gtctcctaag catgctgact gcatccgaaa ggcccccact
6001 caccatggtc tgccctcacc ccacatatgt gtgtacacgc gcacgcctgt atgtgcgctg
6061 ccctcagaca tgcaagtgaa aggaggaggc ttctgtgtaa atgcactttc ttcctcccct
6121 ctttctccat aagaccccag gcagaggtgg gtgcctcccc tcccctcttt gtcactttgg
6181 tttcctataa atatgtatgt atcgtatgtg catctttgct attgtaaata actttgacct
6241 tttttgttcc tgttcctgaa gtgctggagg cagttatgga aggagctgct tagggaagag
6301 gggtttcact tgtatctcct tagttaacaa cccagttcca ggatcgagcc taaagcggga
6361 gccaggcctg agtgttcctg tccctgtgag tgggaaggtc ttctggctcc ccatcccacc
6421 tggctccaga gcctgccctc cacagcttgc tgccaagcta ctccctccct ccctggactt
6481 ctcatcttca caagatgggg atcatggggg tttcttaccc cacctatgtc cccctcttcc
6541 ccaccctgtc cctgtagaaa accagtgaag caggtacgga gctgaggact gggccccagg
6601 aggtggggac aggggtctga atgccgagtc cctgaattca cccaggacca tccaaggggc
6661 caccgcagca ttggccccat caccacgtcc tcacccaact ctccctgatg aatagaatat
6721 acacactgtg ctaggtgtat atatacatat atatatatat aaatatatat ataatatata
6781 aaatatagat atggaaatga ctgttctgct gttaagataa tgtatactct tttattttct
6841 tcctttcatg gttaagattt tttttttaag aaaagttaaa tatccttcaa aaaaaaaaaa
6901 aaaa
//