LOCUS BC054878 980 bp mRNA linear HUM 11-DEC-2003
DEFINITION Homo sapiens solute carrier organic anion transporter family,
member 1B1, mRNA (cDNA clone IMAGE:4766537), partial cds.
ACCESSION BC054878
VERSION BC054878.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 980)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 980)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (03-JUL-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: CLONTECH
cDNA Library Preparation: CLONTECH Laboratories, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 48 Row: g Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 19923779.
FEATURES Location/Qualifiers
source 1..980
/db_xref="H-InvDB:HIT000259471"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4766537"
/tissue_type="Liver"
/clone_lib="NIH_MGC_76"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..>980
/gene="SLCO1B1"
/gene_synonym="LST-1"
/gene_synonym="OATP-C"
/gene_synonym="OATP1B1"
/gene_synonym="OATP2"
/gene_synonym="SLC21A6"
/db_xref="GeneID:10599"
/db_xref="MIM:604843"
CDS 93..>980
/gene="SLCO1B1"
/gene_synonym="LST-1"
/gene_synonym="OATP-C"
/gene_synonym="OATP1B1"
/gene_synonym="OATP2"
/gene_synonym="SLC21A6"
/codon_start=1
/product="SLCO1B1 protein"
/protein_id="AAH54878.1"
/db_xref="GeneID:10599"
/db_xref="MIM:604843"
/translation="MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLG
AIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVGYFGSKLHRPKLIGIGCF
IMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGK
GCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMI
GPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPF
FFLPQTPNKPQKKKKKKKKK"
misc_feature 231..890
/gene="SLCO1B1"
/gene_synonym="LST-1"
/gene_synonym="OATP-C"
/gene_synonym="OATP1B1"
/gene_synonym="OATP2"
/gene_synonym="SLC21A6"
/note="OATP_C; Region: Organic Anion Transporter
Polypeptide (OATP) family, C-terminus. This family
consists of several eukaryotic Organic-Anion-Transporting
Polypeptides (OATPs). Several have been identified mostly
in human and rat. Different OATPs vary in tissue
distribution and substrate specificity. Since the
numbering of different OATPs in particular species was
based originally on the order of discovery, similarly
numbered OATPs in humans and rats did not necessarily
correspond in function, tissue distribution and substrate
specificity (in spite of the name, some OATPs also
transport organic cations and neutral molecules). Thus,
Tamai et al. initiated the current scheme of using digits
for rat OATPs and letters for human ones. Prostaglandin
transporter (PGT) proteins are also considered to be OATP
family members. In addition, the methotrexate transporter
OATK is closely related to OATPs. This family aligns
residues towards the C-terminus. The family OATP_N aligns
residues from similar proteins towards the N-terminus.
This family also includes several predicted proteins from
Caenorhabditis elegans and Drosophila melanogaster. This
similarity was not previously noted. Note: Members of this
family are described as belonging to the SLC21 family of
transporters"
/db_xref="CDD:pfam03137"
BASE COUNT 310 a 162 c 187 g 321 t
ORIGIN
1 gggggcagtt gctgtaggat tctaaatcca ggtgattgtt tcaaactgag catcaacaac
61 aaaaacattt gtatgatatc tatatttcaa tcatggacca aaatcaacat ttgaataaaa
121 cagcagaggc acaaccttca gagaataaga aaacaagata ctgcaatgga ttgaagatgt
181 tcttggcagc tctgtcactc agctttattg ctaagacact aggtgcaatt attatgaaaa
241 gttccatcat tcatatagaa cggagatttg agatatcctc ttctcttgtt ggttttattg
301 acggaagctt tgaaattgga aatttgcttg tgattgtatt tgtgggttac tttggatcca
361 aactacatag accaaagtta attggaatcg gttgtttcat tatgggaatt ggaggtgttt
421 tgactgcttt gccacatttc ttcatgggat attacaggta ttctaaagaa actaatatca
481 attcatcaga aaattcaaca tcgaccttat ccacttgttt aattaatcaa attttatcac
541 tcaatagagc atcacctgag atagtgggaa aaggttgttt aaaggaatct gggtcataca
601 tgtggatata tgtgttcatg ggtaatatgc ttcgtggaat aggggagact cccatagtac
661 cactggggct ttcttacatt gatgatttcg ctaaagaagg acattcttct ttgtatttag
721 gtatattgaa tgcaatagca atgattggtc caatcattgg ctttaccctg ggatctctgt
781 tttctaaaat gtacgtggat attggatatg tagatctaag cactatcagg ataactccta
841 ctgattctcg atgggttgga gcttggtggc ttaatttcct tgtgtctgga ctattctcca
901 ttatttcttc cataccattc tttttcttgc cccaaactcc aaataaacca caaaaaaaaa
961 aaaaaaaaaa aaaaaaaaaa
//