LOCUS BC054492 4639 bp mRNA linear HUM 27-JAN-2004
DEFINITION Homo sapiens RAB GTPase activating protein 1, mRNA (cDNA clone
MGC:54135 IMAGE:5785896), complete cds.
ACCESSION BC054492
VERSION BC054492.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4639)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4639)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-JUL-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 98 Row: h Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 12232372.
FEATURES Location/Qualifiers
source 1..4639
/db_xref="H-InvDB:HIT000054069"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:54135 IMAGE:5785896"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_71"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4639
/gene="RABGAP1"
/gene_synonym="GAPCENA"
/gene_synonym="TBC1D11"
/db_xref="GeneID:23637"
CDS 331..3324
/gene="RABGAP1"
/gene_synonym="GAPCENA"
/gene_synonym="TBC1D11"
/codon_start=1
/product="RABGAP1 protein"
/protein_id="AAH54492.1"
/db_xref="GeneID:23637"
/translation="MDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQK
PEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSIL
RSQCQISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFA
FTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIF
TFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFG
LLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLF
MTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRER
KNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPL
LSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLA
GCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAY
SVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFY
QLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGIS
VIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQK
KLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIAL
RKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIK
KNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGIS
STKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQA
AKKTWFNRTLSSIKTATGVQGKETC"
misc_feature 541..942
/gene="RABGAP1"
/gene_synonym="GAPCENA"
/gene_synonym="TBC1D11"
/note="PTB; Region: Phosphotyrosine-binding domain,
phosphotyrosine-interaction (PI) domain"
/db_xref="CDD:smart00462"
misc_feature 1801..2394
/gene="RABGAP1"
/gene_synonym="GAPCENA"
/gene_synonym="TBC1D11"
/note="TBC; Region: Domain in Tre-2, BUB2p, and Cdc16p.
Probable Rab-GAPs. Widespread domain present in Gyp6 and
Gyp7, thereby giving rise to the notion that it performs a
GTP-activator activity on Rab-like GTPases"
/db_xref="CDD:smart00164"
misc_feature 2488..3063
/gene="RABGAP1"
/gene_synonym="GAPCENA"
/gene_synonym="TBC1D11"
/note="ERM; Region: Ezrin/radixin/moesin family. This
family of proteins contain a band 4.1 domain (pfam00373),
at their amino terminus. This family represents the rest
of these proteins"
/db_xref="CDD:pfam00769"
BASE COUNT 1401 a 922 c 1080 g 1236 t
ORIGIN
1 ggcccaggcg gcggagcctc cgggacggcg agcggcgggc ggcggaggag gagacggcag
61 gtcgggcatt aaaaaatatt taatcattca tgtgttgaga ctcattcttg agttatggat
121 gacaaggctt ctgttggaaa aatcagtgtc tcttcagact cagtatctac tcttaatagt
181 gaagattttg tcttggtttc caggcaagga gatgagacac catctacaaa taatggaagt
241 gatgatgaga aaacaggact caagattgta gggaatggaa gtgaacagca gctgcaaaaa
301 gagctagcag atgtactgat ggatcctcca atggacgacc agccagggga aaaggagctt
361 gtgaaaaggt cacaactgga tggtgaagga gatgggcctc tttctaatca gctctccgct
421 tcatccacca ttaaccctgt gccattagta gggctccaaa aaccagagat gagcctacca
481 gtgaaacctg gacaaggaga ttctgaagct tcaagtcctt tcacaccagt ggccgatgag
541 gacagcgtag ttttcagtaa actgacttac ttaggctgtg cctcggtaaa tgctcccagg
601 agtgaagtgg aagccttaag gatgatgtcc atcttaagaa gccagtgtca gatttcacta
661 gatgttaccc tttcagtgcc gaatgtgtct gaaggaattg tgagactctt agatcctcag
721 acaaacactg aaatagcaaa ctaccctatc tacaaaatcc tcttctgtgt cagagggcat
781 gatggaactc ctgagagtga ctgttttgct ttcactgaaa gtcattacaa tgcagagctc
841 ttcagaatac acgtcttccg gtgtgaaata caagaagctg taagccggat actttacagt
901 tttgccactg ccttccgccg ttctgccaag cagaccccac tttcagccac tgctgcaccc
961 cagactcctg acagtgacat ctttaccttc tctgtgtctt tagaaataaa agaagatgat
1021 ggtaaaggtt attttagtgc agttcccaaa gataaggaca gacagtgctt taaactacgc
1081 caaggaattg ataagaagat tgtcatctat gtgcagcaaa caactaataa agaacttgcc
1141 attgaaaggt gttttggtct tctccttagt ccaggaaaag atgtacgaaa tagtgacatg
1201 cacttattag atttggaatc tatgggcaaa agttcagatg gaaagtcgta tgttattacg
1261 gggagctgga atccaaaatc cccacatttt caagttgtaa atgaagaaac tcctaaagat
1321 aaagtcctgt ttatgaccac agctgtagat ttggtaataa cagaagtaca ggagcctgtt
1381 cgatttctcc tggagacaaa agtccgcgtt tgctcaccta atgaaagatt attctggccc
1441 ttcagcaaac gtagtactac tgaaaatttc tttttgaaac taaaacagat aaagcaaagg
1501 gagagaaaga ataatactga cactttatat gaagttgtat gcttggaaag tgaatcagaa
1561 agagagagga ggaaaactac agccagtcct tcagttcgcc tgccacagtc tggatcgcaa
1621 agttcagtga taccttctcc tccagaagat gatgaagagg aagataatga tgaacctctc
1681 ctgagtggat ctggtgatgt atccaaagaa tgtgcagaaa aaattcttga aacatgggga
1741 gaactgttgt caaaatggca tctcaacttg aatgtgagac cgaagcagtt gtcatcctta
1801 gtaagaaacg gtgtccctga agctcttcga ggagaagtct ggcagctgct agcaggctgt
1861 cataacaatg accacctggt agagaaatac cgcattctta tcacaaagga gtctccccag
1921 gacagtgcta tcacccggga tattaaccga acattcccag cccatgacta ctttaaggac
1981 acaggaggag atggacaaga ttccttatat aaaatatgca aggcttattc tgtgtatgat
2041 gaagagattg gttattgcca gggccagtca tttcttgctg ctgtgctcct tctccatatg
2101 cctgaagaac aggcattcag tgttctggtc aagatcatgt ttgactatgg gctcagggaa
2161 cttttcaagc aaaacttcga agatttgcat tgcaaatttt accagttgga gcgcctcatg
2221 caggaataca ttcctgacct gtacaaccac ttcctggata taagccttga agcacacatg
2281 tatgcctccc agtggtttct tactcttttc actgcaaaat tccctctcta catggtcttc
2341 catatcatcg acctgctttt atgtgaggga ataagtgtta tttttaatgt cgcccttgga
2401 ttattaaaga cttcgaaaga tgacctgctg ttgacagact ttgaaggtgc cttgaagttc
2461 tttagggttc agcttcctaa gagataccgc tcagaagaaa atgcaaaaaa actaatggaa
2521 ttagcctgca acatgaagat tagtcagaag aagttgaaaa aatacgagaa agaatatcac
2581 accatgaggg aacagcaggc ccagcaagaa gaccccatcg agcgatttga gcgggagaat
2641 aggcgtctac aagaagctaa catgaggttg gaacaggaaa acgatgactt agcccatgag
2701 ctggtgacca gcaagattgc actacggaag gacctggata acgctgagga aaaggcagat
2761 gctctgaata aggagctgct gatgaccaaa cagaagttga ttgatgcaga agaagagaaa
2821 agacggctgg aagaagagtc tgctcagtta aaagaaatgt gccgtcggga actcgacaag
2881 gcagaatctg agattaaaaa aaacagttct atcattggtg actataagca gatttgttct
2941 cagttgagtg aaagattgga gaagcagcag acagccaata aggtggaaat tgagaaaatt
3001 cggcaaaaag tggatgactg tgagcggtgc cgggaatttt tcaacaaaga agggcgtgta
3061 aaaggcataa gctcaaccaa ggaggtttta gatgaggaca cggatgaaga gaaagagacg
3121 ctcaagaacc agctgagaga aatggagcta gaactggcac agaccaaact ccagctggtg
3181 gaggccgagt gtaagataca ggacttggaa caccatttag ggcttgccct caatgaggtg
3241 caggcagcca agaagacgtg gtttaaccga acactgagct ccataaagac agcaaccggg
3301 gttcaaggga aagagacttg ctgagagcag ctgccgcctc ccgacacctt cagaaaacac
3361 gacacctttt gttgccttct ttggccagat gtgtgattct gtgacttgtc ccaggaccag
3421 aatgtaccta agtcagatcc atagacgcat gttggtaggt cactggacca gagcttgtga
3481 agcaggcaac ctctggggta agactactga tactaacagg cctgctagct cagccgacgc
3541 tctggacact ctagaaatca ctcctcagtg tgacctccca ggcctcttcc ccgtgtacgt
3601 caacacctca cccagcctaa aggctgagtt tacatgatca gagttagggg atccttcagt
3661 ctgttgattt tttttctaaa cctttttttt tttaatatac atatatatat atatatatat
3721 atatatatat atatatatat atatgtatat gtgtatatat atatatatat atatatatat
3781 atatatatat atatatatat atatatatat atatatatat atatatatat atatatatat
3841 atatagtggg ggtggggcaa gggatcagaa attcaaataa ttcttttctg cttcaatgcc
3901 agcagaaggt cccccaggta gacatggaga agcactttgt tttaaatagg agggtttcat
3961 agttgcatct gaagccacct ggttctgtta aactgtatcg tgcaggtttt gggtttggca
4021 ttattcatgt ttctgatcaa ttctatgcaa ctctcatagt tcctgttact ttttagcatt
4081 agctgccaaa tgacttcaaa aggctggggt gggtgacttg actgtgagac tggattataa
4141 catggacaaa tcttattttg cttaatgtgt ttgtgtgtgt gtgtgtgtgt gtgtgtgtat
4201 gtatatatat atatatataa atatctttcc caatatgccc cgttgacagt gtttaaattc
4261 cagactagga ctgctgatct gcacaattta attatgtggt tattcgagca cttaatttca
4321 ctcaaggttc attgggctct gctctcctcc ctgccattac gggagctgtg gacagagctc
4381 cctcacttca agattcctag tgtttttgca caacaggttg tccaagtgag aaagactgag
4441 ttgcgtgtct gtaaatgtct gcgcagggtg cacatgctgc gaggtctcca tcctccgggc
4501 ctgtccctcc cagatgggct gggcctttgg gccctcctca gagtatgcct gggtacaaac
4561 ctcactgttc agatgggctg taagttctca cttcaaagct atggaatgga ttttagcacc
4621 tttaaaaaaa aaaaaaaaa
//