LOCUS BC053616 5326 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1, mRNA (cDNA clone IMAGE:6142666), partial cds.
ACCESSION BC053616
VERSION BC053616.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5326)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5326)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (09-JUN-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 115 Row: k Column: 20.
FEATURES Location/Qualifiers
source 1..5326
/db_xref="H-InvDB:HIT000259315"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:6142666"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..5326
/gene="PREX1"
/gene_synonym="P-REX1"
/db_xref="GeneID:57580"
/db_xref="HGNC:HGNC:32594"
/db_xref="MIM:606905"
CDS <1..4453
/gene="PREX1"
/gene_synonym="P-REX1"
/codon_start=2
/product="PREX1 protein"
/protein_id="AAH53616.1"
/db_xref="GeneID:57580"
/db_xref="HGNC:HGNC:32594"
/db_xref="MIM:606905"
/translation="LLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDH
PAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTL
LKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVM
EVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQR
ESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLL
EIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDI
MSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALG
VGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRL
LILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEV
ESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMA
AGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARA
SQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYE
YVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPH
FEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHI
NLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKC
LPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVAL
KEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVC
FKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPC
DMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKE
ECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLR
RDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC
QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALK
VIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQ
SLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKP
GAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKC
IMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL"
BASE COUNT 1214 a 1561 c 1540 g 1011 t
ORIGIN
1 gcttctggga ggccggaaga ccacggacat ccctttggaa ggctacctgt tgtctccgat
61 ccagaggatc tgcaagtacc cgctcctcct taaggagctg gccaagagga ctcccggcaa
121 gcacccagac caccccgcgg tccagagtgc cctgcaggcc atgaagaccg tttgctccaa
181 catcaatgag accaagcggc agatggagaa gctggaagcc ctggagcagc tgcagtccca
241 catcgaaggc tgggagggtt ccaacctcac agacatctgc actcagctcc tcctgcaagg
301 gactttgtta aagatctctg cgggcaacat ccaggaaagg gccttcttcc tcttcgacaa
361 ccttctcgtc tactgcaagc ggaaatccag ggtcaccggg agcaagaagt ccaccaagag
421 gaccaaatcc atcaacggct ccctctacat cttcaggggt cgaatcaaca ctgaagtcat
481 ggaggtggag aatgtggaag atgggacagc ggattaccat agcaacggct ataccgtcac
541 caacggctgg aagatccaca acacggccaa gaataagtgg tttgtctgca tggccaagac
601 ggcagaggag aagcagaagt ggctggatgc catcatccgc gagcgggagc agcgcgagag
661 cctgaagctg ggcatggagc gtgatgccta cgtcatgatt gcggagaagg gggagaagct
721 gtaccacatg atgatgaaca agaaggtgaa cctcatcaag gaccgccgga gaaagctgag
781 cactgtcccc aagtgctttc ttggcaatga gttcgttgcc tggctcctag aaattggtga
841 aatcagcaag acggaagaag gagtcaactt gggccaagcc ctgttggaga atggcatcat
901 ccaccatgtt tccgacaagc accagttcaa gaatgagcag gtgatgtatc gcttccgcta
961 cgacgatggc acctacaagg cccgaagtga gctggaggac atcatgtcca agggtgtgag
1021 gctttactgc cgtcttcaca gcctctacac cccggtgatc aaagaccgtg attaccacct
1081 gaagacctac aagtcagtgc ttcccgggag caagctggtg gactggctgc tggctcaggg
1141 agactgccag actcgggagg aggcagtggc gctcggcgtg ggtctgtgca acaatggctt
1201 catgcaccac gtgctggaga agagcgagtt cagggatgag tcccagtact tccgctttca
1261 tgctgacgag gagatggagg ggaccagcag caagaacaaa cagcttcgca acgacttcaa
1321 gctggtggag aacattctgg ccaagcgcct gctgatcctg ccccaggagg aggactatgg
1381 ctttgacatc gaggagaaga acaaggctgt ggtggtgaag tccgtccaga ggggctcgct
1441 ggctgaggtg gctggcctgc aggtggggag gaagatctac tccatcaatg aggacctggt
1501 gttcctgcgg ccgttttcag aggtggagtc catcctcaac cagtccttct gctcccgccg
1561 ccctctgcgc ctcctggtgg ccacgaaggc caaagagatc atcaaaatcc ccgaccagcc
1621 ggacacactg tgcttccaga ttcgtggagc tgccccaccg tacgtctatg ctgtggggag
1681 aggctctgag gccatggctg cagggctctg tgctggtcag tgcattctga aggtcaatgg
1741 cagcaacgtg atgaacgatg gtgcccctga ggtcctggag cacttccagg cattccggag
1801 tcggcgcgaa gaggccctgg gcctgtacca gtggatctac cacacccatg aggatgccca
1861 ggaagcacga gccagtcagg aggcctccac tgaggacccc agtggcgagc aggcccagga
1921 ggaagaccag gctgattcag ccttcccact gctgtccctg ggtccccggc tgagcctgtg
1981 tgaggacagc cccatggtca ccctgactgt ggacaacgtg cacctggaac acggcgtggt
2041 gtatgagtat gtgagcacgg caggcgtcag gtgccatgtg ctggagaaga tcgtggagcc
2101 ccgcggctgc ttcggcctca ccgccaagat cctcgaggcc tttgctgcca atgacagcgt
2161 cttcgtggag aactgcaggc ggctcatggc cctgagcagc gccatcgtga ccatgcccca
2221 ctttgagttc cgcaacatct gtgacaccaa gctggagagc attggccaga ggattgcctg
2281 ctaccaggag tttgcagccc aactgaagag cagggtcagc ccacccttca aacaagcccc
2341 cctggagccc cacccgctgt gtggcctgga cttctgcccc accaattgcc acatcaacct
2401 catggaagtg tcctacccca agaccacccc ctcagtgggc aggtccttca gcatccgctt
2461 tggacgcaaa ccctccctca tcggccttga cccggagcaa ggccacctga accccatgtc
2521 gtacacccag cactgcatca ccaccatggc tgctccctcc tggaagtgct tgcctgctgc
2581 agagggtgat ccccaaggcc agggtctcca tgatggcagc ttcgggccag ccagtgggac
2641 ccttggtcag gaagaccggg gcctcagctt cctactcaag caggaggacc gtgagatcca
2701 ggatgcctac ctgcagctct tcaccaagct ggatgtggcc ctgaaggaga tgaagcaata
2761 tgtcacccag atcaacaggc tgctgtccac catcacagag cccacctcgg gtgggtcctg
2821 cgacgcatcc ttggctgagg aggcctcctc cctgcccctg gtcagtgaag agagcgagat
2881 ggacaggagt gaccatgggg gcatcaagaa ggtgtgcttc aaggtggccg aggaggacca
2941 ggaggactca ggccacgaca ccatgagtta tcgcgactcc tacagcgagt gtaacagcaa
3001 tcgagactcg gtcctgtcct acaccagcgt gagaagtaac agctcctact tgggcagcga
3061 cgagatgggg tctggagatg agctgccctg tgacatgcgg atcccatctg acaagcagga
3121 caagcttcat ggctgcctgg agcacctctt taaccaggtg gactccatca atgctctcct
3181 caaggggcca gtcatgagcc gggctttcga agagaccaag catttcccta tgaaccacag
3241 cttacaagag tttaaacaga aagaagagtg tacaatccgt ggccggagcc tgatccagat
3301 tagcatccag gaggacccct ggaacctccc caactccatc aagaccctgg tggacaacat
3361 tcagagatat gtggaagatg ggaagaacca gctgctcctg gccttgctga agtgcacaga
3421 cacggagctg cagctgcgca gagacgcgat cttctgccag gccctggtgg ccgccgtgtg
3481 caccttctcc gagcagctgc tggcggccct gggctaccgc tacaacaaca atggcgagta
3541 cgaggagagc agccgcgacg ccagccgcaa gtggctggag caggtggcgg ccacgggcgt
3601 cctgctgcac tgccagtccc tgctctcgcc agccacagtg aaggaggaac ggaccatgct
3661 ggaggacatc tgggtgacgc tgtcagagct ggacaatgtc accttctcct ttaagcagct
3721 ggacgagaac tatgtggcca acaccaacgt cttctaccac attgagggca gccggcaggc
3781 gctgaaggtc atcttctacc tcgacagcta ccacttctcc aagctgccct cccgcctgga
3841 gggtggggcc agcctgaggc tgcacacagc gctgttcacg aaagtgctgg agaacgtgga
3901 ggggctgcct tctccaggca gccaggccgc ggaggatttg cagcaggaca tcaacgcgca
3961 gtccctggag aaagttcagc agtattaccg caaactcagg gcattttacc tggagcggtc
4021 taacctgccc acggatgcca gcaccacggc ggtaaagata gaccagctga tccgccccat
4081 caatgccctg gatgagctct gccgcctcat gaagtccttt gtccacccaa agcctggtgc
4141 tgctgggagt gtgggcgccg gcctcatccc catctcctcg gagctctgct accgcctggg
4201 ggcctgccag atggtcatgt gtggcacagg catgcagagg agcaccctga gcgtgtccct
4261 ggagcaggcg gccatcttgg cacggagcca cgggttgctg cccaagtgca tcatgcaggc
4321 cacggacatc atgcggaagc agggcccaag ggtggagatt ctggccaaaa acctgcgagt
4381 caaggaccag atgccccagg gtgctccgcg cctctaccgc ctctgccagc cgccggtgga
4441 tggggacctc tgaacaccca aatgccccac gctgggccgc ggcctctgga gctgggattt
4501 gggaggacac agcaggcagc gctggccttc tccagggatg gcccaaggct tccgcagccg
4561 cccgttccgg gacctgccca gcgtcctccc tgcctccttc cgggacaagc ctggccaccc
4621 tcgctgtgat gacgagctgg ctgattggcc ctgggccggc ccattcttca cacgcctgcc
4681 agaagctgga ggggtgctgg agacccatag agctgatggg agcagctggt gcctggcctt
4741 cggctcctgc gtccccagaa cccaagggaa cgtcatggag gccacatggg gccacccggc
4801 tccctcggga tggctccgcc tgcacttttg aaaccccggt ttccttcaac gtccacattc
4861 caggtgacca cacgtgtctc ctcctcctca tcttagcttc caggttcacc ctaaccctgt
4921 actaacctgc ttggtggact tggaaaagac ttggctctgt cgggaaagga gagacggggc
4981 ctccatcacg cctgttacca gaggatcccc gagagccaca ccagctctgg acatcaccgc
5041 ccctggaact ggggccacca gccctgggca cgagatttgc tctgacttta tttatatggc
5101 atgaaatctc tggtttattt tgggattttt tgttgttggt gttgtcaaag tttgtttttt
5161 ctaaagttgt gtgattatat atttgacatt ttacatttca aagaaaggta tgttgtctaa
5221 caggggacca acagaaggta gtattgacaa ctgttcctgc ttctactaaa aaaaaaagag
5281 cacaaaagaa aaactaaatt attgaaaaat taaaaaaaaa aaaaaa
//