LOCUS BC051787 5306 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens NLR family, pyrin domain containing 1, mRNA (cDNA
clone MGC:57544 IMAGE:5756099), complete cds.
ACCESSION BC051787
VERSION BC051787.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5306)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5306)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-MAY-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 107 Row: j Column: 23
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 41350306
The stop codon of the CDS annotated on this record is located > 55
bases upstream of a splice junction, and therefore the mRNA is
predicted to be subject to nonsense-mediated mRNA decay (NMD).
FEATURES Location/Qualifiers
source 1..5306
/db_xref="H-InvDB:HIT000053680"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:57544 IMAGE:5756099"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..5306
/gene="NLRP1"
/gene_synonym="CARD7"
/gene_synonym="CLR17.1"
/gene_synonym="DEFCAP"
/gene_synonym="DEFCAP-L/S"
/gene_synonym="NAC"
/gene_synonym="PP1044"
/gene_synonym="SLEV1"
/gene_synonym="VAMAS1"
/db_xref="GeneID:22861"
/db_xref="HGNC:HGNC:14374"
/db_xref="MIM:606636"
CDS 553..4680
/gene="NLRP1"
/gene_synonym="CARD7"
/gene_synonym="CLR17.1"
/gene_synonym="DEFCAP"
/gene_synonym="DEFCAP-L/S"
/gene_synonym="NAC"
/gene_synonym="PP1044"
/gene_synonym="SLEV1"
/gene_synonym="VAMAS1"
/codon_start=1
/product="NLRP1 protein"
/protein_id="AAH51787.1"
/db_xref="GeneID:22861"
/db_xref="HGNC:HGNC:14374"
/db_xref="MIM:606636"
/translation="MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQ
PEKTSGMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSE
PHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQAL
PSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTE
IREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQ
KFTQLLLLQRSHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQG
AAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATP
APIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILP
EASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVK
SNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP
QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLSYSFIHL
CFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEG
EREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEE
MGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQ
ILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKD
LAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDL
ASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR
ALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLK
LLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTG
PVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQ
HSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCS
IRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGRNTSQPWNLRCNRDARRY"
BASE COUNT 1247 a 1497 c 1454 g 1108 t
ORIGIN
1 gttgactagg cgctgttctt gctggctggt gccccagggc ctggagaggt ctgaagaaac
61 ctgggagcca gcagcccggg gctccactct gggttctgaa agcccattcc ctgctctgcg
121 gctcctccca ccccacctct tctcagcctt gcagctcaag ggttgatctc aggagtccag
181 gacccaggag agggaagaat ctgaggaaca cagaacagtg agcgttgccc acaccccatc
241 tcccgtcacc acatctcccc tcaccctcac cctccctgcc tggccctgga ccccatccca
301 ggacctccct atcagctgac ttcttccagt gtcttgcagg cccctctggg ctcctccctc
361 ccctggcttt tcctaccact ccccctctat cggcgtctat ctgtaggtgc cctgggattt
421 ataaaactgg gttccgaatg ctgaataaga gacggtaaga gccaaggcaa aggacagcac
481 tgttctctgc ctgcctgata ccctcaccac ctgggaacat cccccagaca ccctcttaac
541 tccgggacag agatggctgg cggagcctgg ggccgcctgg cctgttactt ggagttcctg
601 aagaaggagg agctgaagga gttccagctt ctgctcgcca ataaagcgca ctccaggagc
661 tcttccggtg agacacccgc tcagccagag aagacgagtg gcatggaggt ggcctcgtac
721 ctggtggctc agtatgggga gcagcgggcc tgggacctag ccctccatac ctgggagcag
781 atggggctga ggtcactgtg cgcccaagcc caggaagggg caggccactc tccctcattc
841 ccctacagcc caagtgaacc ccacctgggg tctcccagcc aacccacctc caccgcagtg
901 ctaatgccct ggatccatga attgccggcg gggtgcaccc agggctcaga gagaagggtt
961 ttgagacagc tgcctgacac atctggacgc cgctggagag aaatctctgc ctcactcctc
1021 taccaagctc ttccaagctc cccagaccat gagtctccaa gccaggagtc acccaacgcc
1081 cccacatcca cagcagtgct ggggagctgg ggatccccac ctcagcccag cctagcaccc
1141 agagagcagg aggctcctgg gacccaatgg cctctggatg aaacgtcagg aatttactac
1201 acagaaatca gagaaagaga gagagagaaa tcagagaaag gcaggccccc atgggcagcg
1261 gtggtaggaa cgcccccaca ggcgcacacc agcctacagc cccaccacca cccatgggag
1321 ccttctgtga gagagagcct ctgttccaca tggccctgga aaaatgagga ttttaaccaa
1381 aaattcacac agctgctact tctacaaaga tctcacccca gaagccaaga tcccctggtc
1441 aagagaagct ggcctgatta tgtggaggag aatcgaggac atttaattga gatcagagac
1501 ttatttggcc caggcctgga tacccaagaa cctcgcatag tcatactgca gggggctgct
1561 ggaattggga agtcaacact ggccaggcag gtgaaggaag cctgggggag aggccagctg
1621 tatggggacc gcttccagca tgtcttctac ttcagctgca gagagctggc ccagtccaag
1681 gtggtgagtc tcgctgagct catcggaaaa gatgggacag ccactccggc tcccattaga
1741 cagatcctgt ctaggccaga gcggctgctc ttcatcctcg atggtgtaga tgagccagga
1801 tgggtcttgc aggagccgag ttctgagctc tgtctgcact ggagccagcc acagccggcg
1861 gatgcactgc tgggcagttt gctggggaaa actatacttc ccgaggcatc cttcctgatc
1921 acggctcgga ccacagctct gcagaacctc attccttctt tggagcaggc acgttgggta
1981 gaggtcctgg ggttctctga gtccagcagg aaggaatatt tctacagata tttcacagat
2041 gaaaggcaag caattagagc ctttaggttg gtcaaatcaa acaaagagct ctgggccctg
2101 tgtcttgtgc cctgggtgtc ctggctggcc tgcacttgcc tgatgcagca gatgaagcgg
2161 aaggaaaaac tcacactgac ttccaagacc accacaaccc tctgtctaca ttaccttgcc
2221 caggctctcc aagctcagcc attgggaccc cagctcagag acctctgctc tctggctgct
2281 gagggcatct ggcaaaaaaa gacccttttc agtccagatg acctcaggaa gcatgggtta
2341 gatggggcca tcatctccac cttcttgaag atgggtattc ttcaagagca ccccatccct
2401 ctgagctaca gcttcattca cctctgtttc caagagttct ttgcagcaat gtcctatgtc
2461 ttggaggatg agaaggggag aggtaaacat tctaattgca tcatagattt ggaaaagacg
2521 ctagaagcat atggaataca tggcctgttt ggggcatcaa ccacacgttt cctattgggc
2581 ctgttaagtg atgaggggga gagagagatg gagaacatct ttcactgccg gctgtctcag
2641 gggaggaacc tgatgcagtg ggtcccgtcc ctgcagctgc tgctgcagcc acactctctg
2701 gagtccctcc actgcttgta cgagactcgg aacaaaacgt tcctgacaca agtgatggcc
2761 catttcgaag aaatgggcat gtgtgtagaa acagacatgg agctcttagt gtgcactttc
2821 tgcattaaat tcagccgcca cgtgaagaag cttcagctga ttgagggcag gcagcacaga
2881 tcaacatgga gccccaccat ggtagtcctg ttcaggtggg tcccagtcac agatgcctat
2941 tggcagattc tcttctccgt cctcaaggtc accagaaacc tgaaggagct ggacctaagt
3001 ggaaactcgc tgagccactc tgcagtgaag agtctttgta agaccctgag acgccctcgc
3061 tgcctcctgg agaccctgcg gttggctggc tgtggcctca cagctgagga ctgcaaggac
3121 cttgcctttg ggctgagagc caaccagacc ctgaccgagc tggacctgag cttcaatgtg
3181 ctcacggatg ctggagccaa acacctttgc cagagactga gacagccgag ctgcaagcta
3241 cagcgactgc agctggtcag ctgtggcctc acgtctgact gctgccagga cctggcctct
3301 gtgcttagtg ccagccccag cctgaaggag ctagacctgc agcagaacaa cctggatgac
3361 gttggcgtgc gactgctctg tgaggggctc aggcatcctg cctgcaaact catacgcctg
3421 gggctggacc agacaactct gagtgatgag atgaggcagg aactgagggc cctggagcag
3481 gagaaacctc agctgctcat cttcagcaga cggaaaccaa gtgtgatgac ccctactgag
3541 ggcctggata cgggagagat gagtaatagc acatcctcac tcaagcggca gagactcgga
3601 tcagagaggg cggcttccca tgttgctcag gctaatctca aactcctgga cgtgagcaag
3661 atcttcccaa ttgctgagat tgcaggcaag agccacgagg aaagctcccc agaggtagta
3721 ccggtggaac tcttgtgcgt gccttctcct gcctctcaag gggacctgca tacgaagcct
3781 ttggggactg acgatgactt ctggggcccc acggggcctg tggctactga ggtagttgac
3841 aaagaaaaga acttgtaccg agttcacttc cctgtagctg gctcctaccg ctggcccaac
3901 acgggtctct gctttgtgat gagagaagcg gtgaccgttg agattgaatt ctgtgtgtgg
3961 gaccagttcc tgggtgagat caacccacag cacagctgga tggtggcagg gcctctgctg
4021 gacatcaagg ctgagcctgg agctgtggaa gctgtgcacc tccctcactt tgtggctctc
4081 caagggggcc atgtggacac atccctgttc caaatggccc actttaaaga ggaggggatg
4141 ctcctggaga agccagccag ggtggagctg catcacatag ttctggaaaa ccccagcttc
4201 tcccccttgg gagtcctcct gaaaatgatc cataatgccc tgcgcttcat tcccgtcacc
4261 tctgtggtgt tgctttacca ccgcgtccat cctgaggaag tcaccttcca cctctacctg
4321 atcccaagtg actgctccat tcggaaggcc atagatgatc tagaaatgaa attccagttt
4381 gtgcgaatcc acaagccacc cccgctgacc ccactttata tgggctgtcg ttacactgtg
4441 tctgggtctg gttcagggat gctggaaata ctccccaagg aactggagct ctgctatcga
4501 agccctggag aagaccagct gttctcggag ttctacgttg gccacttggg atcagggatc
4561 aggctgcaag tgaaagacaa gaaagatgag actctggtgt gggaggcctt ggtgaaacca
4621 ggaaggaaca ccagccagcc gtggaacctc aggtgcaaca gagacgccag gagatactag
4681 tgcccagcag cctgcggcag taccaatgaa gccagagagg gcttggtgga tgacaaggag
4741 gcctgagtag accgcagact ttgttgtcgc tgcccggagg agtcgagact ggtacccgga
4801 ggagctgtct caccaggaga ccacgtcctg gaagtgtccg ggactcgcgg gacctgtggc
4861 tgcagacccc gccggcacgc aggcccagag ctggcgcact cctgaggatg agactctggg
4921 ggccctagcc ggggtccacg ggagggctgt ccttggggac tctaggatgg cttcgttctg
4981 gcccggctca cttctggagc tgtgagaccc aagacaaaag gggctgaggg atttctcatt
5041 gacaagagtt cgtgcgggaa aaccacctga cccctaggga tttgtcatct taagactcaa
5101 aaggcttaat accaggaacc accttggcaa gatatttacc caccggccat ctctgtttac
5161 tcatgaatgt taaatgttaa aacgcagcgc tctaaccctg catattattt acttgcaaat
5221 gtctgtaatc tgtaattgtg atgcctctga tggaataaat tatctttttc agtctcctct
5281 aaaaaaaaaa aaaaaaaaaa aaaaaa
//