LOCUS BC050585 4267 bp mRNA linear HUM 16-SEP-2003
DEFINITION Homo sapiens integrin, alpha 6, mRNA (cDNA clone IMAGE:6150124),
partial cds.
ACCESSION BC050585
VERSION BC050585.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4267)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4267)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 107 Row: m Column: 3.
FEATURES Location/Qualifiers
source 1..4267
/db_xref="H-InvDB:HIT000259146"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:6150124"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_72"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..4267
/gene="ITGA6"
/gene_synonym="CD49f"
/db_xref="GeneID:3655"
/db_xref="MIM:147556"
CDS <1..2062
/gene="ITGA6"
/gene_synonym="CD49f"
/codon_start=2
/product="ITGA6 protein"
/protein_id="AAH50585.1"
/db_xref="GeneID:3655"
/db_xref="MIM:147556"
/translation="KDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANG
INTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTI
TVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSG
LSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQE
PSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGN
QDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPD
TLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDT
PDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKS
EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKES
HNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILR
SRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYS
GVPWWIILVAILAGILMLALLVFILWKCGFFKRNKKDHYDATYHKAEIHAQPSDKERL
TSDA"
misc_feature 5..160
/gene="ITGA6"
/gene_synonym="CD49f"
/note="Int_alpha; Region: Integrin alpha (beta-propellor
repeats). Integrins are cell adhesion molecules that
mediate cell-extracellular matrix and cell-cell
interactions. They contain both alpha and beta subunits.
Alpha integrins are proposed to contain a domain
containing a 7-fold repeat that adopts a beta-propellor
fold. Some of these domains contain an inserted von
Willebrand factor type-A domain. Some repeats contain
putative calcium-binding sites. The 7-fold repeat domain
is homologous to a similar domain in
phosphatidylinositol-glycan-specific phospholipase D"
/db_xref="CDD:smart00191"
misc_feature 176..247
/gene="ITGA6"
/gene_synonym="CD49f"
/note="Int_alpha; Region: Integrin alpha (beta-propellor
repeats). Integrins are cell adhesion molecules that
mediate cell-extracellular matrix and cell-cell
interactions. They contain both alpha and beta subunits.
Alpha integrins are proposed to contain a domain
containing a 7-fold repeat that adopts a beta-propellor
fold. Some of these domains contain an inserted von
Willebrand factor type-A domain. Some repeats contain
putative calcium-binding sites. The 7-fold repeat domain
is homologous to a similar domain in
phosphatidylinositol-glycan-specific phospholipase D"
/db_xref="CDD:smart00191"
BASE COUNT 1336 a 780 c 868 g 1283 t
ORIGIN
1 caaagattct atgtttggca ttgcagtaaa aaatattgga gatattaatc aagatggcta
61 cccagatatt gcagttggag ctccgtatga tgacttggga aaggttttta tctatcatgg
121 atctgcaaat ggaataaata ccaaaccaac acaggttctc aagggtatat caccttattt
181 tggatattca attgctggaa acatggacct tgatcgaaat tcctaccctg atgttgctgt
241 tggttccctc tcagattcag taactatttt cagatcccgg cctgtgatta atattcagaa
301 aaccatcaca gtaactccta acagaattga cctccgccag aaaacagcgt gtggggcgcc
361 tagtgggata tgcctccagg ttaaatcctg ttttgaatat actgctaacc ccgctggtta
421 taatccttca atatcaattg tgggcacact tgaagctgaa aaagaaagaa gaaaatctgg
481 gctatcctca agagttcagt ttcgaaacca aggttctgag cccaaatata ctcaagaact
541 aactctgaag aggcagaaac agaaagtgtg catggaggaa accctgtggc tacaggataa
601 tatcagagat aaactgcgtc ccattcccat aactgcctca gtggagatcc aagagccaag
661 ctctcgtagg cgagtgaatt cacttccaga agttcttcca attctgaatt cagatgaacc
721 caagacagct catattgatg ttcacttctt aaaagaggga tgtggagacg acaatgtatg
781 taacagcaac cttaaactag aatataaatt ttgcacccga gaaggaaatc aagacaaatt
841 ttcttattta ccaattcaaa aaggtgtacc agaactagtt ctaaaagatc agaaggatat
901 tgctttagaa ataacagtga caaacagccc ttccaaccca aggaatccca caaaagatgg
961 cgatgacgcc catgaggcta aactgattgc aacgtttcca gacactttaa cctattctgc
1021 atatagagaa ctgagggctt tccctgagaa acagttgagt tgtgttgcca accagaatgg
1081 ctcgcaagct gactgtgagc tcggaaatcc ttttaaaaga aattcaaatg tcacttttta
1141 tttggtttta agtacaactg aagtcacctt tgacacccca gatctggata ttaatctgaa
1201 gttagaaaca acaagcaatc aagataattt ggctccaatt acagctaaag caaaagtggt
1261 tattgaactg cttttatcgg tctcgggagt tgctaaacct tcccaggtgt attttggagg
1321 tacagttgtt ggcgagcaag ctatgaaatc tgaagatgaa gtgggaagtt taatagagta
1381 tgaattcagg gtaataaact taggtaaacc tcttacaaac ctcggcacag caaccttgaa
1441 cattcagtgg ccaaaagaaa ttagcaatgg gaaatggttg ctttatttgg tgaaagtaga
1501 atccaaagga ttggaaaagg agtctcacaa ctcaagaaag aaacgggaaa ttactgaaaa
1561 acagatagat gataacagaa aattttcttt atttgctgaa agaaaatacc agactcttaa
1621 ctgtagcgtg aacgtgaact gtgtgaacat cagatgcccg ctgcgggggc tggacagcaa
1681 ggcgtctctt attttgcgct cgaggttatg gaacagcaca tttctagagg aatattccaa
1741 actgaactac ttggacattc tcatgcgagc cttcattgat gtgactgctg ctgccgaaaa
1801 tatcaggctg ccaaatgcag gcactcaggt tcgagtgact gtgtttccct caaagactgt
1861 agctcagtat tcgggagtac cttggtggat catcctagtg gctattctcg ctgggatctt
1921 gatgcttgct ttattagtgt ttatactatg gaagtgtggt ttcttcaaga gaaataagaa
1981 agatcattat gatgccacat atcacaaggc tgagatccat gctcagccat ctgataaaga
2041 gaggcttact tctgatgcat agtattgatc tacttctgta attgtgtgga ttctttaaac
2101 gctctaggta cgatgacagt gttccccgat accatgctgt aaggatccgg aaagaagagc
2161 gagagatcaa agatgaaaag tatattgata accttgaaaa aaaacagtgg atcacaaagt
2221 ggaacgaaaa tgaaagctac tcatagcggg ggcctaaaaa aaaaaagctt cacagtaccc
2281 aaactgcttt ttccaactca gaaattcaat ttggatttaa aagcctgctc aatccctgag
2341 gactgatttc agagtgacta cacacagtac gaacctacag ttttaactgt ggatattgtt
2401 acgtagccta aggctcctgt tttgcacagc caaatttaaa actgttggaa tggatttttc
2461 tttaactgcc gtaatttaac tttctgggtt gcctttattt ttggcgtggc tgacttacat
2521 catgtgttgg ggaagggcct gcccagttgc actcaggtga catcctccag atagtgtagc
2581 tgaggaggca cctacactca cctgcactaa cagagtggcc gtcctaacct cgggcctgct
2641 gcgcagacgt ccatcacgtt agctgtccca catcacaaga ctatgccatt ggggtagttg
2701 tgtttcaacg gaaagtgctg tcttaaacta aatgtgcaat agaaggtgat gttgccatcc
2761 taccgtcttt tcctgtttcc tagctgtgtg aatacctgct cacgtcaaat gcatacaagt
2821 ttcattctcc ctttcactaa aacacacagg tgcaacagac ttgaatgcta gttatactta
2881 tttgtatatg gtatttattt tttcttttct ttacaaacca ttttgttatt gactaacagg
2941 ccaaagagtc tccagtttac ccttcaggtt ggtttaatca atcagaatta gagcatggga
3001 ggtcatcact ttgacctaaa ttatttactg caaaaagaaa atctttataa atgtaccaga
3061 gagagttgtt ttaataactt atctataaac tataacctct ccttcatgac agcctccacc
3121 ccacaaccca aaaggtttaa gaaatagaat tataactgta aagatgttta tttcaggcat
3181 tggatatttt ttactttaga agcctgcata atgtttctgg atttcatact gtaacattca
3241 ggaattcttg gagaaaatgg gtttattcac tgaactctag tgcggtttac tcactgctgc
3301 aaatactgta tattcaggac ttgaaagaaa tggtgaatgc ctatggtgga tccaaactga
3361 tccagtataa gactactgaa tctgctacca aaacagttaa tcagtgagtc gatgttctat
3421 tttttgtttt gtttcctccc ctatctgtat tcccaaaaat tactttgggg ctaatttaac
3481 aagaacttta aattgtgttt taattgtaaa aatggcaggg ggtggaatta ttactctata
3541 cattcaacag agactgaata gatatgaaag ctgatttttt ttaattacca tgcttcacaa
3601 tgttaagtta tatggggagc aacagcaaac aggtgctaat ttgttttgga tatagtataa
3661 gcagtgtctg tgttttgaaa gaatagaaca cagtttgtag tgccactgtt gttttggggg
3721 ggcttttttc ttttcggaaa tcttaaacct taagatacta aggacgttgt tttggttgta
3781 ctttggaatt cttagtcaca aaatatattt tgtttacaaa aatttctgta aaacaggtta
3841 taacagtgtt taaagtctca gtttcttgct tggggaactt gtgtccctaa tgtgtttaga
3901 ttgctagatt gctaaggagc tgatactttg acagtgtttt tagacctgtg ttactaaaaa
3961 aaagatgaat gtcctgaaaa gggtgttggg agggtggttc aacaaagaaa caaagatgtt
4021 atggtgttta gatttatggt tgttaaaaat gtcatctcaa gtcaagtcac tggtctgttt
4081 gcatttgata catttttgta ctaactagca ttgtaaaatt atttcatgat tagaaattac
4141 ctgtggatat ttgtataaaa gtgtgaaata aattttttat aaaagtgttc attgtttcgt
4201 aacacagcat tgtatatgtg aagcaaactc taaaattata aatgacaacc tgaaaaaaaa
4261 aaaaaaa
//