LOCUS BC048798 4705 bp mRNA linear HUM 02-MAR-2004
DEFINITION Homo sapiens zinc finger protein 589, mRNA (cDNA clone
IMAGE:5547444), partial cds.
ACCESSION BC048798
VERSION BC048798.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4705)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4705)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (14-MAR-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 93 Row: o Column: 21
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7706726.
FEATURES Location/Qualifiers
source 1..4705
/db_xref="H-InvDB:HIT000099013"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:5547444"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..4705
/gene="ZNF589"
/gene_synonym="SZF1"
/db_xref="GeneID:51385"
CDS <1..1138
/gene="ZNF589"
/gene_synonym="SZF1"
/codon_start=2
/product="ZNF589 protein"
/protein_id="AAH48798.1"
/db_xref="GeneID:51385"
/translation="VLLPRLLRACVRAQMWAPREQLLGWTAEALPAKDSAWPWEEKPR
YLGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCP
LAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQR
VEGGVRPLFWSTNERGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRIS
KRAETPGFGAVTFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQ
LIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYLI
RHQRTHTREKSFMCTVCGRGFREKSELIKHQRIHTGDKPYVCRD"
misc_feature 146..265
/gene="ZNF589"
/gene_synonym="SZF1"
/note="KRAB; Region: KRAB box. The KRAB domain (or
Kruppel-associated box) is present in about a third of
zinc finger proteins containing C2H2 fingers. The KRAB
domain is found to be involved in protein-protein
interactions. The KRAB domain is generally encoded by two
exons. The regions coded by the two exons are known as
KRAB-A and KRAB-B"
/db_xref="CDD:pfam01352"
misc_feature 788..853
/gene="ZNF589"
/gene_synonym="SZF1"
/note="zf-C2H2; Region: Zinc finger, C2H2 type. The C2H2
zinc finger is the classical zinc finger domain. The two
conserved cysteines and histidines co-ordinate a zinc ion.
The following pattern describes the zinc finger.
#-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be
any amino acid, and numbers in brackets indicate the
number of residues. The positions marked # are those that
are important for the stable fold of the zinc finger. The
final position can be either his or cys. The C2H2 zinc
finger is composed of two short beta strands followed by
an alpha helix. The amino terminal part of the helix binds
the major groove in DNA binding zinc fingers"
/db_xref="CDD:pfam00096"
misc_feature 1037..1105
/gene="ZNF589"
/gene_synonym="SZF1"
/note="zf-C2H2; Region: Zinc finger, C2H2 type. The C2H2
zinc finger is the classical zinc finger domain. The two
conserved cysteines and histidines co-ordinate a zinc ion.
The following pattern describes the zinc finger.
#-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be
any amino acid, and numbers in brackets indicate the
number of residues. The positions marked # are those that
are important for the stable fold of the zinc finger. The
final position can be either his or cys. The C2H2 zinc
finger is composed of two short beta strands followed by
an alpha helix. The amino terminal part of the helix binds
the major groove in DNA binding zinc fingers"
/db_xref="CDD:pfam00096"
BASE COUNT 1215 a 1084 c 1230 g 1176 t
ORIGIN
1 ggtgctgcta cctcgtttgc ttcgtgcgtg cgtgcgcgcg cagatgtggg ccccgcggga
61 gcagctactg ggctggactg cggaagctct gcctgccaag gattctgcct ggccctggga
121 agagaagcct agatatctgg gaccagtgac tttcgaggat gtggctgtgc ttttcactga
181 ggcagagtgg aagagactga gccttgagca gaggaaccta tacaaagaag tgatgctgga
241 aaatctcagg aatctggtct cattggcaga atcaaagcca gaagtccata cctgcccttc
301 ttgccctctg gcctttggca gtcagcagtt cctcagccaa gatgagctac acaatcatcc
361 tattccaggt ttccatgcag gaaatcaact ccacccagga aatccctgcc cagaggatca
421 gccacagtca caacatcctt ctgataaaaa tcacaggggg gctgaagcag aagatcaacg
481 agtggaagga ggcgtcagac ccttgttttg gagtacaaat gaaagggggg ctttagtggg
541 tttctctagc ctgttccaga gaccaccaat aagctcttgg ggaggcaaca gaatattaga
601 gatacagctc agtccagccc agaatgcaag ctctgaggaa gtagacagaa tttccaagag
661 ggcagaaacc ccagggtttg gagcagtcac gtttggggag tgtgcactag cttttaacca
721 gaagtcaaac ctgttcagac agaaggcagt cacagcagaa aaatcttcag acaaaaggca
781 gtcacaggtg tgcagggagt gtgggcgagg ctttagcagg aagtcacagc tcatcataca
841 ccagaggaca cacacaggag aaaagcctta tgtctgcgga gagtgtgggc gaggctttat
901 agttgagtca gtcctccgca accacctgag tacacactcc ggggagaaac cttatgtgtg
961 cagccattgt gggcgaggct ttagctgcaa gccatacctc atcagacatc agaggacaca
1021 cacaagggag aaatcgttta tgtgcacagt gtgtgggcga ggctttcgtg aaaagtcaga
1081 gctcattaag caccagagaa ttcacacggg ggataagcct tatgtgtgca gagattgagg
1141 ccgaggcttt gtaaggagat catgtctcaa cacacaccag aggatacatt cagatgagaa
1201 gccttttgtt tgcagagagt gtgggcgagg ctttcgtgct aaatcaactc tcctcctaca
1261 ccagtggaca cattcagagg tgaaacctca cgtgtgtgag gagtgtgggc atggatttag
1321 ccagaagtcg tcgctcaaat cacatcggag aacacactca ggggagaagc cttatgtgtg
1381 tggggaatgt gggcggggat ttagccggag gatagtcctc aatggacact ggaggacaca
1441 cacgggagag aagccttaca cgtgctttga gtgtgggcga aactttagcc tcaagtccgc
1501 tcttagtgta catcagagga tacactctgg ggagaagcct tatgcatgca cggagtgtgg
1561 gcaaggcttt atcacgaaat cacagctcat cagacaccag aggacacaca caggagaaaa
1621 gccttatgtc tgcggagagt gtgggcgagg ctttatagct cagtcaaccc tccactacca
1681 ccggagtaca cactccaagg aaaaacctta tgtgtgcagc cagtgtgggc gaggcttttg
1741 tgataaatca actctcctcg cacacgagca gacacattca ggggagaagc cttatgtgtg
1801 tggggaatgt gggcggggat ttggccggaa gatactcctc aacagacact ggaggacaca
1861 cacaggagag aaaccttacg catgcatcga gtgtgggcga aactttagcc acaagtccac
1921 tctcagctta catcagagga tacactcggg ggagaagcct tatgcatgcg tggagtgtgg
1981 gcaaagcttt aggagaaagt cacagctcat catacaccag aagatacact cggggaaaag
2041 ctttagaggt gcaaggagtg aggatgtgat tttagcaaca agtcagccat cagccacacc
2101 agcggaaatg cttagggaga agccttgttt gtaaggtaat gtggacagag ctgtacgtgg
2161 acatcattac ttgtcacgtg tcagaggaca cactcgggag aaaccttcat ggagtgagag
2221 taaggtgttg gctggaagtg gccccttaag agatacttgg agtcaaatct atccactgta
2281 cgcccacccc actcttgttc taagagcttt ggggacagtc ttttgacccc ttacattcct
2341 ttagatgtga agatgacaga gatctaactt ctgagagcag aggtgtcaag tgacggtccc
2401 cttggaggaa tggtctttgc atctgactac ttccttctgc aactgtgttc ttccattagc
2461 ttccatgaca ctctcctgct ttattttttt ctacatctct agcctttgct gtttcctctc
2521 ctaccccacc tttagatttt actcagagtt cagtctccag ccctacaatc tgagggacac
2581 ctttaccagg tccccttcct aaccctccag tcccaaatcc aagattcttt aaccacactc
2641 taaaagttct tcagactcag gacttaaaca tagccacgcc accttggcct tcaatgacag
2701 ggatctagca atgctgcatc atcagccttc caataccagg tttaagggta ttttaaacac
2761 agctcctctt aaatcctcca atctcagtac ccagtgtttt agccatgctc gggtggctaa
2821 attacatcca ggaatggtgc cagggccttt agccatttgt ctctcctcac actccagggc
2881 ccatatggcc caggttctga cagtttgcct tactcccttg ggctggggct agccctacct
2941 gataccctgt gtcaatgagt gtaccttgga gagctatcca ctcaggcccc agtgcctcta
3001 tttgctaagg gactctgcca cagaaaagaa ggggagagat gttcatgtaa cctcaaaata
3061 cttaggcttg gttttgatgc tagagaggaa aaaggacttg gagagagaga aggaatggct
3121 ggtccagagg cttttgtcca ctccctctca ctggaagtgg ttgatctcca gggaatcccc
3181 aaggttagcc tgcttagggg aagggctagg ggtacctgga atgtaggatc tcccccatgc
3241 ctggcctacc accctaatgt gtctggaatt ggtgggttct tggtcttgct gacttcaaga
3301 atgaagccgt ggaccctcac gttctggaac tgggaagtcc aagatcaggg ctcctgcccc
3361 tggacctgaa cctggatctt tggctttgat gttggacctt gtgtgtggat atgaactttg
3421 aacctgcacc ttggaactaa acctctgact tggatttgtt ctgcattttg gaactcacct
3481 tagacctgaa ccttggtcat gaaatggatc tgaatcattc ttgggtcttg gacatgggac
3541 ttggacctcc atgtgtatct tggacttagg accatgatct ggaccttgta aattgacttg
3601 gactttggac ttggaccttg gactagaatt tgtccctggc tgtggacctc gtctttggat
3661 ctggatctgg acctggtctt ggatgttgga cctagatgca ggccttgatt tgatttggaa
3721 catggacttg gtccttgcac atggcccaac acccgcgtct ttggaactgc atcttggacc
3781 ttggatctga aatttaaaca gggaggtgac cttcatttct tgtatttgac tttataactg
3841 gaaattcaat ctctacctgg atcttggacc tggatctcag accttgcttt ttattgggcc
3901 atggatctta taccttaaac atggaaattg tacctggatt tggacctttg acttggacct
3961 ggatctggac ccagggataa gatttggacc tcacttgcaa attttggtaa tgaaattttc
4021 ctttgctcct gtagtccttg gacctaggct tcagtcatgg atttagacct tagacgtgac
4081 catcagacct tagagttgaa cctaaattcc tggtccccag tcctataact cagaatgatt
4141 atgcataacc ttggacttag aacttagatc tggatcttag agctgatact tgacctggta
4201 ctggatattt aaccttggac ttcagacatg gatttaatct gggccttggg atgatttaag
4261 atctagaagt ggacctagaa ttagaccttg gacttatgtg cctgagcctg gactttggaa
4321 gtggactttg ggccttgtaa ctcaaccttg aatatgagcc tcaaatgtag actgtgggcc
4381 aggcacggtg gctcacatct gtaatcccag cactttgggt ggaaagctga ggcaggtgga
4441 tcacttgagc tcaggaattc gggaccagcc tggggaacat ggtgaaaacc tggctctaca
4501 aaaaataaaa aagttagcca ggcttggtgg cgcacgcctg tggttccggg tactcgggag
4561 gctgaggcag gaggttcact tgggcccggg aggcagaggt tgcagtgagc tgagcttgtg
4621 cagctgcact ccagcctgga ggacagagtg agactctgtc tcaagaaaaa aaaataaaaa
4681 ataaataaat aaaaaaaaaa aaaaa
//