LOCUS BC047415 2578 bp mRNA linear HUM 19-MAR-2007
DEFINITION Homo sapiens cancer susceptibility candidate 1, mRNA (cDNA clone
MGC:50992 IMAGE:5269578), complete cds.
ACCESSION BC047415
VERSION BC047415.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2578)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2578)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (28-FEB-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 91 Row: c Column: 5
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 41350207.
FEATURES Location/Qualifiers
source 1..2578
/db_xref="H-InvDB:HIT000098575"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:50992 IMAGE:5269578"
/tissue_type="Testis"
/clone_lib="NIH_MGC_97"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..2578
/gene="CASC1"
/gene_synonym="LAS1"
/db_xref="GeneID:55259"
/db_xref="HGNC:HGNC:29599"
CDS 259..2289
/gene="CASC1"
/gene_synonym="LAS1"
/codon_start=1
/product="CASC1 protein"
/protein_id="AAH47415.2"
/db_xref="GeneID:55259"
/db_xref="HGNC:HGNC:29599"
/translation="MERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEK
LKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLI
EKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSG
NMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYD
HVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIK
VEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSSEKPDFFEDNVV
DLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPETTEEFETENAF
PPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVTFSLDTFGPV
TLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIKLKDKKHI
SILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAF
AFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLKIKEESEAFSE
ALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS"
BASE COUNT 913 a 433 c 539 g 693 t
ORIGIN
1 gtcgtccggg caacccggga gcgtttgtcc acacaatttc tgctccgact ctgcggacta
61 ctgcagtgga gcttgactct taatgggtcc caaagcaaaa aaggaacact gtcatcacaa
121 acaggcttca gtggccaaag atctggcagt aagaaaaaga aagtcaccaa agctgaacga
181 ttgaagctgc tacaagagga ggaggagaga cgactgaaag aggaagagga agcccgtttg
241 aaatatgaga aagaagaaat ggaaaggctt gaaatacagc gaattgagaa agaaaaatgg
301 catcgacttg aagcaaaaga tctagaaagg agaaatgaag aacttgaaga actttattta
361 ttagagaggt gttttcctga agcagagaaa ttgaaacagg aaactaaatt gctttctcag
421 tggaagcact acattcaatg tgatgggagt cctgatcctt cagtagccca agaaatgaac
481 acgtttatta gtttgtggaa agagaaaaca aatgagactt ttgaggaagt gattgagaag
541 agtaaagtag tgctaaattt aattgagaaa ttgaaattta ttttactgga aactccacca
601 tgtgatttgc aagataaaaa tataatacag taccaagaat caatactaca actgcaggag
661 ctccttcatc ttaaattcgg tgtagccaca gaaatacttc tcaaacaagc tagtactttg
721 gcagatctgg acagtggaaa tatggaaaaa gtcattaaag atgaaaatgt tactctgtat
781 gtgtgggcaa acctcaagaa gaatccaagg cacagaagtg ttagattctc tgaaacacaa
841 attggatttg agattccaag gatattagca acaagtgaca ttgctgtacg actcctgcat
901 acccactatg atcatgtttc tgcactgcac cctgtttcaa caccatcaaa agaatacact
961 tctgcagtaa ctgagcttgt caaagatgat gttaagaatg tagaaaaagc aatcagcaag
1021 gaggtcgaag aagagtccaa acaacaagaa agagggtctc acttaattca ggaggaagaa
1081 ataaaagttg aggaggaaca aggtgatatt gaagtgaaaa tgagttctgc tgaggaagaa
1141 tctgaagcca taaaatgtga acgagagatg aaagtattaa gtgaaactgt ttcagcagca
1201 cagttgttgc tggtagagaa ttcttctgaa aagccagatt tctttgaaga caatgtggtg
1261 gatttatgcc agttcacaac tctgggtgga gtataccact tggatatttt ggagcttcct
1321 ccacagtgta aaccagtgaa gggatggatg attgtggaaa tactcaaaga aggattacag
1381 aaatacacat atcctccgga aactacagaa gagtttgaga cagaaaatgc tttcccacct
1441 atagaggtca cacttgaggt tcatgagaat gtaatctttt ttgaggatcc tgtggttgta
1501 aggtgggatg ctgaaggtaa acattggaga actgatggca tcagcaatgt atcctacaaa
1561 ccaaaagaaa gacttgtaac attcagcctg gacacctttg gccctgttac cttgattcaa
1621 gatgctcata ttaacatgcc gtaccagtca tgggaactaa gaccacttga tgtaaataaa
1681 gtacttttaa ctgtgactac agtatttact gagattcaaa tacaaattaa ggaaaacctc
1741 tgcatgttat cttcaatcaa actaaaagac aagaaacaca tctctatttt ggaaggaacc
1801 tggatgactc ctattccttt cattattgct ttgaaagaag ctggactgaa tatctttcct
1861 actagacact ctcattttta tgttattata aacaataagg ttcctttggt agaagtgaaa
1921 gcttatcgac agatggccct actaagttct gcttttgcat ttggttggag caagtggaac
1981 ctactatgta attctacaaa agtcgtattt aaggtgaggg aacaccttac tgaagaatgt
2041 actgagaatc ctaattgggc ccttttaatg tttagtggtg acagagcaca aagactgaag
2101 atcaaggaag agagtgaggc attttctgaa gcacttaaag aagaaactga gtttcattct
2161 actttatatc acatggtgaa ggattttgct tctgaggaag caatggagaa agtcaggagt
2221 tccaactgtc agtttgtcaa ctctgtgtgc cacatgctgc tctctaccag attgctcagc
2281 tactcctaac ctccacttac aaactgtatt gtaagtatga agaaccaagc atggtgaaag
2341 acaggtattt ctgcaacaca atgtaatgag tgaatgaata catttcaaat caactattaa
2401 aaattttcta atctgcattt tctactcaag ttttatttta aaaacagtat ttttttttcc
2461 tttgaatact tggcctgtta agaatttcag ctttcactct atgaagattt aaatgattct
2521 ttatttcaat aaactttaac aaacaataaa aaaaaaaaaa agaaaaaaaa aaaaaaaa
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