LOCUS BC042531 4035 bp mRNA linear HUM 01-SEP-2006
DEFINITION Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member
4, mRNA (cDNA clone MGC:41801 IMAGE:4837724), complete cds.
ACCESSION BC042531
VERSION BC042531.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4035)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4035)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-JAN-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 72 Row: l Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 9961253.
FEATURES Location/Qualifiers
source 1..4035
/db_xref="H-InvDB:HIT000097268"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:41801 IMAGE:4837724"
/tissue_type="Testis"
/clone_lib="NIH_MGC_97"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4035
/gene="ABCB4"
/gene_synonym="ABC21"
/gene_synonym="MDR2/3"
/gene_synonym="PFIC-3"
/db_xref="GeneID:5244"
/db_xref="HGNC:HGNC:45"
/db_xref="MIM:171060"
CDS 113..3973
/gene="ABCB4"
/gene_synonym="ABC21"
/gene_synonym="MDR2/3"
/gene_synonym="PFIC-3"
/codon_start=1
/product="ATP-binding cassette, sub-family B (MDR/TAP),
member 4"
/protein_id="AAH42531.1"
/db_xref="GeneID:5244"
/db_xref="HGNC:HGNC:45"
/db_xref="MIM:171060"
/translation="MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLT
LFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSL
LNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQ
EIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTL
VIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKEL
ERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAM
TVFFSILIGAFSAGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKG
NLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE
GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKE
ANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE
SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVY
FKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD
VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFG
PGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQ
DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQL
TLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERK
FESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD
VILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKF
EGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDP
LAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV
SQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL
LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT
HQQLLAQKGIYFSMVSVQAGTQNL"
BASE COUNT 1171 a 818 c 1023 g 1023 t
ORIGIN
1 gggggggggc gggggcgggg gcgaggccgc ggcgagcaaa gtccaggccc ctctgctgca
61 gcgcccgcgc gtccagaggc cctgccagac acgcgcgagg ttcgaggctg agatggatct
121 tgaggcggca aagaacggaa cagcctggcg ccccacgagc gcggagggcg actttgaact
181 gggcatcagc agcaaacaaa aaaggaaaaa aacgaagaca gtgaaaatga ttggagtatt
241 aacattgttt cgatactccg attggcagga taaattgttt atgtcgctgg gtaccatcat
301 ggccatagct cacggatcag gtctccccct catgatgata gtatttggag agatgactga
361 caaatttgtt gatactgcag gaaacttctc ctttccagtg aacttttcct tgtcgctgct
421 aaatccaggc aaaattctgg aagaagaaat gactagatat gcatattact actcaggatt
481 gggtgctgga gttcttgttg ctgcctatat acaagtttca ttttggactt tggcagctgg
541 tcgacagatc aggaaaatta ggcagaagtt ttttcatgct attctacgac aggaaatagg
601 atggtttgac atcaatgaca ccactgaact caatacgcgg ctaacagatg acatctccaa
661 aatcagtgaa ggaattggtg acaaggttgg aatgttcttt caagcagtag ccacgttttt
721 tgcaggattc atagtgggat tcatcagagg atggaagctc acccttgtga taatggccat
781 cagccctatt ctaggactct ctgcagccgt ttgggcaaag atactctcgg catttagtga
841 caaagaacta gctgcttatg caaaagcagg cgccgtggca gaagaggctc tgggggccat
901 caggactgtg atagctttcg ggggccagaa caaagagctg gaaaggtatc agaaacattt
961 agaaaatgcc aaagagattg gaattaaaaa agctatttca gcaaacattt ccatgggtat
1021 tgccttcctg ttaatatatg catcatatgc actggccttc tggtatggat ccactctagt
1081 catatcaaaa gaatatacta ttggaaatgc aatgacagtt tttttttcaa tcctaattgg
1141 agctttcagt gctggccagg ctgccccatg tattgatgct tttgccaatg caagaggagc
1201 agcatatgtg atctttgata ttattgataa taatcctaaa attgacagtt tttcagagag
1261 aggacacaaa ccagacagca tcaaagggaa tttggagttc aatgatgttc acttttctta
1321 cccttctcga gctaacgtca agatcttgaa gggcctcaac ctgaaggtgc agagtgggca
1381 gacggtggcc ctggttggaa gtagtggctg tgggaagagc acaacggtcc agctgataca
1441 gaggctctat gaccctgatg agggcacaat taacattgat gggcaggata ttaggaactt
1501 taatgtaaac tatctgaggg aaatcattgg tgtggtgagt caggagccgg tgctgttttc
1561 caccacaatt gctgaaaata tttgttatgg ccgtggaaat gtaaccatgg atgagataaa
1621 gaaagctgtc aaagaggcca acgcctatga gtttatcatg aaattaccac agaaatttga
1681 caccctggtt ggagagagag gggcccagct gagtggtggg cagaagcaga ggatcgccat
1741 tgcacgtgcc ctggttcgca accccaagat ccttctgctg gatgaggcca cgtcagcatt
1801 ggacacagaa agtgaagctg aggtacaggc agctctggat aaggccagag aaggccggac
1861 caccattgtg atagcacacc gactgtctac ggtccgaaat gcagatgtca tcgctgggtt
1921 tgaggatgga gtaattgtgg agcaaggaag ccacagcgaa ctgatgaaga aggaaggggt
1981 gtacttcaaa cttgtcaaca tgcagacatc aggaagccag atccagtcag aagaatttga
2041 actaaatgat gaaaaggctg ccactagaat ggccccaaat ggctggaaat ctcgcctatt
2101 taggcattct actcagaaaa accttaaaaa ttcacaaatg tgtcagaaga gccttgatgt
2161 ggaaaccgat ggacttgaag caaatgtgcc accagtgtcc tttctgaagg tcctgaaact
2221 gaataaaaca gaatggccct actttgtcgt gggaacagta tgtgccattg ccaatggggg
2281 gcttcagccg gcattttcag tcatattctc agagatcata gcgatttttg gaccaggcga
2341 tgatgcagtg aagcagcaga agtgcaacat attctctttg attttcttat ttctgggaat
2401 tatttctttt tttactttct tccttcaggg tttcacgttt gggaaagctg gcgagatcct
2461 caccagaaga ctgcggtcaa tggcttttaa agcaatgcta agacaggaca tgagctggtt
2521 tgatgaccat aaaaacagta ctggtgcact ttctacaaga cttgccacag atgctgccca
2581 agtccaagga gccacaggaa ccaggttggc tttaattgca cagaatatag ctaaccttgg
2641 aactggtatt atcatatcat ttatctacgg ttggcagtta accctattgc tattagcagt
2701 tgttccaatt attgctgtgt caggaattgt tgaaatgaaa ttgttggctg gaaatgccaa
2761 aagagataaa aaagaactgg aagctgctgg aaagattgca acagaggcaa tagaaaatat
2821 taggacagtt gtgtctttga cccaggaaag aaaatttgaa tcaatgtatg ttgaaaaatt
2881 gtatggacct tacaggaatt ctgtgcagaa ggcacacatc tatggaatta cttttagtat
2941 ctcacaagca tttatgtatt tttcctatgc cggttgtttt cgatttggtg catatctcat
3001 tgtgaatgga catatgcgct tcagagatgt tattctggtg ttttctgcaa ttgtatttgg
3061 tgcagtggct ctaggacatg ccagttcatt tgctccagac tatgctaaag ctaagctgtc
3121 tgcagcccac ttattcatgc tgtttgaaag acaacctctg attgacagct acagtgaaga
3181 ggggctgaag cctgataaat ttgaaggaaa tataacattt aatgaagtcg tgttcaacta
3241 tcccacccga gcaaacgtgc cagtgcttca ggggctgagc ctggaggtga agaaaggcca
3301 gacactagcc ctggtgggca gcagtggctg tgggaagagc acggtggtcc agctcctgga
3361 gcggttctac gaccccttgg cggggacagt gtttgtggac tttggttttc agcttctcga
3421 tggtcaagaa gcaaagaaac tcaatgtcca gtggctcaga gctcaactcg gaatcgtgtc
3481 tcaggagcct atcctatttg actgcagcat tgccgagaat attgcctatg gagacaacag
3541 ccgggttgta tcacaggatg aaattgtgag tgcagccaaa gctgccaaca tacatccttt
3601 catcgagacg ttaccccaca aatatgaaac aagagtggga gataagggga ctcagctctc
3661 aggaggtcaa aaacagagga ttgctattgc ccgagccctc atcagacaac ctcaaatcct
3721 cctgttggat gaagctacat cagctctgga tactgaaagt gaaaaggttg tccaagaagc
3781 cctggacaaa gccagagaag gccgcacctg cattgtgatt gctcaccgcc tgtccaccat
3841 ccagaatgca gacttaatag tggtgtttca gaatgggaga gtcaaggagc atggcacgca
3901 tcagcagctg ctggcacaga aaggcatcta tttttcaatg gtcagtgtcc aggctgggac
3961 acagaactta tgaacttttg ctacagtata ttttaaaaat aaattcaaat tattctacca
4021 aaaaaaaaaa aaaaa
//