LOCUS BC037963 3440 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens adrenergic, beta, receptor kinase 1, mRNA (cDNA clone
MGC:46122 IMAGE:5585846), complete cds.
ACCESSION BC037963
VERSION BC037963.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3440)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3440)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (20-SEP-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 79 Row: d Column: 8.
FEATURES Location/Qualifiers
source 1..3440
/db_xref="H-InvDB:HIT000051974"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:46122 IMAGE:5585846"
/tissue_type="Testis, embryonal carcinoma"
/clone_lib="NIH_MGC_92"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3440
/gene="ADRBK1"
/gene_synonym="BARK1"
/gene_synonym="BETA-ARK1"
/gene_synonym="GRK2"
/db_xref="GeneID:156"
/db_xref="HGNC:HGNC:289"
/db_xref="MIM:109635"
CDS 246..2315
/gene="ADRBK1"
/gene_synonym="BARK1"
/gene_synonym="BETA-ARK1"
/gene_synonym="GRK2"
/codon_start=1
/product="adrenergic, beta, receptor kinase 1"
/protein_id="AAH37963.1"
/db_xref="GeneID:156"
/db_xref="HGNC:HGNC:289"
/db_xref="MIM:109635"
/translation="MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQ
KYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERV
ARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGD
VFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYA
MKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG
GDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRIS
DLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR
QHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES
PFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRN
FPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMS
KMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKI
RGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQ
RGSANGL"
BASE COUNT 667 a 1084 c 1074 g 615 t
ORIGIN
1 ccacgcgtcc gcgactgcag tcccggcggg agcggagcgc gagccggggc cgggcccgag
61 ccggcgccat ggggcggcgc cgcctgtgag cggcggcgag cggagccgcg ggcgccgagc
121 agggccaggc gggaggcgtc ggcgcccgag gccgagcgag ccgcggccgg gccgggccga
181 gcgccgagcg agcaggagcg gcggcggcgg cggcggcggc gggaggaggc agcgccgccg
241 ccaagatggc ggacctggag gcggtgctgg ccgacgtgag ctacctgatg gccatggaga
301 agagcaaggc cacgccggcc gcgcgcgcca gcaagaagat actgctgccc gagcccagca
361 tccgcagtgt catgcagaag tacctggagg accggggcga ggtgaccttt gagaagatct
421 tttcccagaa gctggggtac ctgctcttcc gagacttctg cctgaaccac ctggaggagg
481 ccaggccctt ggtggaattc tatgaggaga tcaagaagta cgagaagctg gagacggagg
541 aggagcgtgt ggcccgcagc cgggagatct tcgactcata catcatgaag gagctgctgg
601 cctgctcgca tcccttctcg aagagtgcca ctgagcatgt ccaaggccac ctggggaaga
661 agcaggtgcc tccggatctc ttccagccat acatcgaaga gatttgtcaa aacctccgag
721 gggacgtgtt ccagaaattc attgagagcg ataagttcac acggttttgc cagtggaaga
781 atgtggagct caacatccac ctgaccatga atgacttcag cgtgcatcgc atcattgggc
841 gcgggggctt tggcgaggtc tatgggtgcc ggaaggctga cacaggcaag atgtacgcca
901 tgaagtgcct ggacaaaaag cgcatcaaga tgaagcaggg ggagaccctg gccctgaacg
961 agcgcatcat gctctcgctc gtcagcactg gggactgccc attcattgtc tgcatgtcat
1021 acgcgttcca cacgccagac aagctcagct tcatcctgga cctcatgaac ggtggggacc
1081 tgcactacca cctctcccag cacggggtct tctcagaggc tgacatgcgc ttctatgcgg
1141 ccgagatcat cctgggcctg gagcacatgc acaaccgctt cgtggtctac cgggacctga
1201 agccagccaa catccttctg gacgagcatg gccacgtgcg gatctcggac ctgggcctgg
1261 cctgtgactt ctccaagaag aagccccatg ccagcgtggg cacccacggg tacatggctc
1321 cggaggtcct gcagaagggc gtggcctacg acagcagtgc cgactggttc tctctggggt
1381 gcatgctctt caagttgctg cgggggcaca gccccttccg gcagcacaag accaaagaca
1441 agcatgagat cgaccgcatg acgctgacga tggccgtgga gctgcccgac tccttctccc
1501 ctgaactacg ctccctgctg gaggggttgc tgcagaggga tgtcaaccgg agattgggct
1561 gcctgggccg aggggctcag gaggtgaaag agagcccctt tttccgctcc ctggactggc
1621 agatggtctt cttgcagaag taccctcccc cgctgatccc cccacgaggg gaggtgaacg
1681 cggccgacgc cttcgacatt ggctccttcg atgaggagga cacaaaagga atcaagttac
1741 tggacagtga tcaggagctc taccgcaact tccccctcac catctcggag cggtggcagc
1801 aggaggtggc agagactgtc ttcgacacca tcaacgctga gacagaccgg ctggaggctc
1861 gcaagaaagc caagaacaag cagctgggcc atgaggaaga ctacgccctg ggcaaggact
1921 gcatcatgca tggctacatg tccaagatgg gcaacccctt cctgacccag tggcagcggc
1981 ggtacttcta cctgttcccc aaccgcctcg agtggcgggg cgagggcgag gccccgcaga
2041 gcctgctgac catggaggag atccagtcgg tggaggagac gcagatcaag gagcgcaagt
2101 gcctgctcct caagatccgc ggtgggaaac agttcatttt gcagtgcgat agcgaccctg
2161 agctggtgca gtggaagaag gagctgcgcg acgcctaccg cgaggcccag cagctggtgc
2221 agcgggtgcc caagatgaag aacaagccgc gctcgcccgt ggtggagctg agcaaggtgc
2281 cgctggtcca gcgcggcagt gccaacggcc tctgacccgc ccacccgcct tttataaacc
2341 tctaatttat tttgtcgaat ttttattatt tgttttcccg ccaagcggaa aaggttttat
2401 tttgtaatta ttgtgatttc ccgtggcccc agcctggccc agctcccccg ggaggggccc
2461 gcttgcctcg gctcctgctg caccaaccca gccgctgccc ggcgccctct gtcctgactt
2521 caggggctgc ccgctcccag tgtcttcctg tgggggaaga gcacagccct cccgcccctt
2581 ccccgaggga tgatgccaca ccaagctgtg ccaccctggg ctctgtgggc tgcactctgt
2641 gcccatgggc actgctgggt ggcccatccc ccctcaccag gggcaggcac agcacaggga
2701 tccgacttga attttcccac tgcaccccct cctgctgcag aggggcaggc cctgcactgt
2761 cctgctccac agtgttggcg agaggagggg cccgttgtct ccctggccct caaggcctcc
2821 cacagtgact cgggctcctg tgcccttatt caggaaaagc ctctgtgtca ctggctgcct
2881 ccactcccac ttccctgaca ctgcggggct tggctgagag agtggcattg gcagcaggtg
2941 ctgctaccct ccctgctgtc ccctcttgcc ccaaccccca gcacccgggc tcagggacca
3001 cagcaaggca cctgcaggtt gggccatact ggcctcgcct ggcctgaggt ctcgctgatg
3061 ctgggctggg tgcgacccca tctgcccagg acggggccgg ccaggtgggc gggcagcaca
3121 gcaaggaggc tggctggggc ctatcagtgt gccccccatc ctggcccatc agtgtacccc
3181 cgcccaggct ggccagcccc acagcccacg tcctgtcagt gccgccgcct cgcccaccgc
3241 atgccccctc gtgccagtcg cgctgcctgt gtggtgtcgc gccttctccc ccccggggct
3301 gggttggcgc accctcccct cccgtctact cattccccgg ggcgtttctt tgccgatttt
3361 tgaatgtgat tttaaagagt gaaaaatgag actatgcgtt tttataaaaa atggtgcctg
3421 aaaaaaaaaa aaaaaaaaaa
//