LOCUS BC036947 4302 bp mRNA linear HUM 12-FEB-2004
DEFINITION Homo sapiens TBC1 domain family, member 16, mRNA (cDNA clone
MGC:46570 IMAGE:5392579), complete cds.
ACCESSION BC036947
VERSION BC036947.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4302)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4302)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (23-AUG-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 78 Row: l Column: 24.
FEATURES Location/Qualifiers
source 1..4302
/db_xref="H-InvDB:HIT000051853"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:46570 IMAGE:5392579"
/tissue_type="Breast, mammary adenocarcinoma."
/clone_lib="NIH_MGC_87"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4302
/gene="TBC1D16"
/gene_synonym="FLJ20748"
/gene_synonym="MGC25062"
/db_xref="GeneID:125058"
CDS 102..1319
/gene="TBC1D16"
/gene_synonym="FLJ20748"
/gene_synonym="MGC25062"
/codon_start=1
/product="TBC1D16 protein"
/protein_id="AAH36947.1"
/db_xref="GeneID:125058"
/translation="MKVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLN
ELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSE
IQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAV
YNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR
ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD
YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL
PRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKK
GPKTPQDGFGFRR"
misc_feature 285..989
/gene="TBC1D16"
/gene_synonym="FLJ20748"
/gene_synonym="MGC25062"
/note="TBC; Region: Domain in Tre-2, BUB2p, and Cdc16p.
Probable Rab-GAPs. Widespread domain present in Gyp6 and
Gyp7, thereby giving rise to the notion that it performs a
GTP-activator activity on Rab-like GTPases"
/db_xref="CDD:smart00164"
BASE COUNT 947 a 1203 c 1262 g 890 t
ORIGIN
1 ccacgcgtcc gcgacccacg cgtccggggg ttggagagag tggggggcgg cggcacagtg
61 ggccggggag gagagagccg cagagggaaa ccgattttaa gatgaaggtc gcccccgata
121 agacatgcat gcagttctcc atccgccgcc ccaagctgcc gtcctccgag acgcaccccg
181 aggagagcat gtacaagagg ctcggcgtct ccgcctggct caaccacctg aatgagctgg
241 gccaggtgga ggaggagtac aagctgcgga aggccatttt ctttggcggt attgatgtgt
301 caatccgcgg ggaggtctgg cccttcctgc tgcgctatta cagccacgag tccacgtcgg
361 aggagcggga ggcgctgcgg ctgcagaagc gaaaggagta ctctgagatc cagcagaaaa
421 ggctctccat gactcccgag gagcacagag cgttctggcg taatgtgcag ttcactgtgg
481 acaaagacgt ggtccggaca gatcggaaca accagttctt ccggggggaa gacaatccca
541 atgtggagag catgaggagg atcctgctga actacgccgt gtacaaccct gccgtcggct
601 attcccaagg gatgtcggac ctggtggcgc ccatcttggc cgaggtcctg gatgagtcag
661 acaccttctg gtgctttgtg ggtttgatgc agaacacgat cttcgtcagc tcaccccggg
721 acgaggacat ggagaaacaa ctgctgtacc tgcgcgagct gctgcggctg acgcacgtgc
781 gcttctacca gcacctggtc tcgctgggcg aggacggcct gcagatgctc ttctgccacc
841 gctggctcct tctgtgcttc aagcgggagt tccccgaggc cgaagcgctg cggatctggg
901 aggcctgctg ggcccactac cagacggact acttccacct tttcatctgc gtggccatcg
961 tggccatcta cggggatgac gtcatcgagc agcagctggc cacggaccag atgctcctgc
1021 acttcggaaa cctggccatg cacatgaacg gggagctcgt tctccggaag gcgaggagtt
1081 tgctgtacca gttccgcctc ctgccccgga tcccctgcag cctgcacgat ctgtgtaagc
1141 tgtgcgggtc aggcatgtgg gacagcggct ccatgcccgc ggtggagtgc accggccacc
1201 atcccggctc ggagagctgt ccctacgggg gcacggtgga gatgccttcc cccaagtccc
1261 tgagggaagg caagaagggc ccaaagacgc cgcaggacgg cttcggcttc cgcagatagg
1321 tcgggccccc gacaccggac aggggttgag gggacctcct cagaggccct gggcacggga
1381 gggggtgggg ctgggcgtga aggggacagg ggacggtaga aacctaagga aaatgctttt
1441 gggcaacatg agaggaacct tttcatatta atgacaaaat tagagtctgg aagtgacaga
1501 agtcagatct acagccaccc agaggaaagt cagctcctga aacgctgcag tggaacgcgc
1561 agccaccgca cctgagacgc aggctggctg ggctctcctg ctggctgccc tggaggattt
1621 caacatgtcc caggatttgc tccaccctcg agggcagcca gacagcgtcg ccaggcaatg
1681 aggaaagcag agacaggaga ggaaggcctc actcacccac tgcgtcgagg gctgcagaac
1741 acagcggggt cctgtccagg cccagggaca tctttgcaag ccagacacac ttcctcttga
1801 gacctcgttc tctcggagtg agccaaacac acttcccaaa acgtccccag ccacagctgg
1861 gatgccgatg gaaaggcatc tgccataaaa gaaaagcaaa agataaaaag cccaaccgat
1921 gtggggatag agaggcggaa gagcagtcag gcttgaggag ctggcgcttg taatgtttat
1981 ccgtttaaac atttcgtctt cctggtacac gaagggaact gtctgcccag gagcctgagc
2041 ctcaggctgt tggagaagca tctgatgcct ttttctttgc tgggggtctt ctacgtgagg
2101 ttccttggcg ttgtttaagg tcaactccac caaatacagc aaccagctgg ggcttgaatg
2161 ggtcgatgtg tgcgtgtgtc cctgcgtgca tgcatgcatg cacacgtgcg tgcgtgtttg
2221 tgtttgcaag atcctctgac aatgatctgc tttgtcccag ggacgtggta gtgtattagc
2281 tgaccaacca agacaaggac acctggaaat agttagactc ttccacttcc cttcaggacc
2341 tgtgaactca gatatgtaag tcagcttctc aggtggtcgg acgtgagagc gaccacagtg
2401 aaggagccag cactcagggc tctctgcctt ctatgtggga atgaggtctt cccaacagac
2461 tctccctctt ccaaaagatt gtgtatcagt tgctccttct gggatttaga gatggacaga
2521 aaagggtgtg cgatctatgc tgtgagaact cccagccagc ttagaagtgt cgagccattt
2581 gcacagaaag ccactccttg agcgaggaga ccaaatccct cctgaaatcc tccatcgcgt
2641 ccttctgggg agaaaaaccc ttgatgtgct gagaaccatc atggggacca ggatagaagg
2701 cttcttccca ctcaaagctt ttctccctgg agggtgggca ctgctgggcc atgccacttc
2761 aaagcagtgt tcctcagcag gaaagcggag gtcaccactt accggcctcc tccaccttct
2821 cggcttctct tttctccatg aacccaggtc gtccagcagg tacttccaag ttcccaggtc
2881 tgtctgccta agagcctttt gaggagaccg tcctggagcc ccatcagtgc ccagatcctg
2941 gggtaccgac cattgctgtc tagcagtggg ggatcctgtg gtgggaatgg ggtgggcttc
3001 tcatccatgt tgcttctggg aagagagggt tgcctttctg ggctagggag gtggctggag
3061 cttctgccct gaccctccgc tagaaaccag ttatatccat tgccacagca atactgtgta
3121 acaaatccgc caacactcgg tggcctgcaa cagtcagcac tgatctaggg caggagtcag
3181 cagtctgggc agggtgattc ttctggtcta ggctgggctt gtttgtttag ggccagtggg
3241 ttgttaagtc ccaggggatg ctcatggtgc agaggtcgga cctggccctg ctctgtggtc
3301 tcttgcatcc ctcctgcagg ccagccatgg cacagccaaa ggcacggagg gagagacagc
3361 aagtgccttt ccaagccttg gtggacacca cacctgcagc tctccccttg gccacagcaa
3421 gtcacgtggc tgggctcagc attaaggggt gggggacagg cctgccactt tattgtccgc
3481 tctgcacagt cgggtggcag taggctgaga atttggaggg ctaaacaact gggactctgg
3541 agagtctgtg tcctaataat gcctgctttg gagcactcct tccccacccg cctgctccag
3601 gggaatagcg tccctggtcc tagcatttca ctagatacct cgtgcctttg aaccgctgtg
3661 tttgggaggg aggaagagga tagacaggtc cagggctccc ctcacttggg aaggtcctag
3721 tagaaggcat tccttctgag tctcctggcc ctacagcttc tcacccctgc tgctccccaa
3781 gacctgaccc ggaccaatca gctgcatctc tgcaccaagt gccaccccca ccgtgcactg
3841 ctcgcacctc acgctcccca tgggctggcc cggaccccag tgaggtctgc acctctcgga
3901 ccagccagga cctcggaagc catgagctgg gtgttcaggg cttggcggag gagacgctgc
3961 tccgcggggg atggagaagc cccgcccctc cacaactccc ttaatctgga tgcaattaga
4021 ggaaaccagc caaaaacccc gcggcagctg ttgccccggg attattccca gccagcgaga
4081 ggcattaggg cgataattca gtcattagac ttctagcctt cccaccgcca gaacgtgcaa
4141 ataggggata atcagccctg cacggccatc ctcagcaatg ctgcttattt aacccatttt
4201 ttaaaatgac acttaatgtt attggctggc gtacgtgtgt gcgcatactt aaaagttgat
4261 gcgtggtgca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//