LOCUS BC036084 2174 bp mRNA linear HUM 17-JUL-2006
DEFINITION Homo sapiens beta-site APP-cleaving enzyme 1, mRNA (cDNA clone
MGC:33762 IMAGE:5311572), complete cds.
ACCESSION BC036084
VERSION BC036084.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2174)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2174)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (31-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 48 Row: p Column: 18.
FEATURES Location/Qualifiers
source 1..2174
/db_xref="H-InvDB:HIT000051617"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:33762 IMAGE:5311572"
/tissue_type="Brain, hypothalamus"
/clone_lib="NIH_MGC_96"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..2174
/gene="BACE1"
/gene_synonym="ASP2"
/gene_synonym="HSPC104"
/gene_synonym="KIAA1149"
/db_xref="GeneID:23621"
/db_xref="HGNC:HGNC:933"
/db_xref="MIM:604252"
CDS 457..1962
/gene="BACE1"
/gene_synonym="ASP2"
/gene_synonym="HSPC104"
/gene_synonym="KIAA1149"
/codon_start=1
/product="beta-site APP-cleaving enzyme 1"
/protein_id="AAH36084.1"
/db_xref="GeneID:23621"
/db_xref="HGNC:HGNC:933"
/db_xref="MIM:604252"
/translation="MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLP
RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG
AAPHPFLHRYYQRQLFSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI
AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA
GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM
DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG
TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT
VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQT
DESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK"
BASE COUNT 430 a 703 c 636 g 405 t
ORIGIN
1 ctttttccgc ctccccagcc cgcccgggag ctgcgagccg cgagctggat tatggtggcc
61 tgagcagcca acgcagccgc aggagcccgg agcccttgcc cctgcccgcg ccgccgcccg
121 ccggggggac cagggaagcc gccaccggcc cgccatgccc gcccctccca gccccgccgg
181 ggcccgcgcc cgctgcccag gctggccgcc gccatgccga tgtagcgggc tccggatccc
241 agcctctccc ctgctcccgt gctctgcgga tctcccctga ccgctctcca cagcccggac
301 ccgggggctg gcccagggcc ctgcaggccc tggcgtcctg atgcccccaa gctccctctc
361 ctgagaagcc accagcacca cccagacttg ggggcaggcg ccagggacgg acgtgggcca
421 gtgcgagccc agagggcccg aaggccgggg cccaccatgg cccaagccct gccctggctc
481 ctgctgtgga tgggcgcggg agtgctgcct gcccacggca cccagcacgg catccggctg
541 cccctgcgca gcggcctggg gggcgccccc ctggggctgc ggctgccccg ggagaccgac
601 gaagagcccg aggagcccgg ccggaggggc agctttgtgg agatggtgga caacctgagg
661 ggcaagtcgg ggcagggcta ctacgtggag atgaccgtgg gcagcccccc gcagacgctc
721 aacatcctgg tggatacagg cagcagtaac tttgcagtgg gtgctgcccc ccaccccttc
781 ctgcatcgct actaccagag gcagctgttc agcacatacc gggacctccg gaagggtgtg
841 tatgtgccct acacccaggg caagtgggaa ggggagctgg gcaccgacct ggtaagcatc
901 ccccatggcc ccaacgtcac tgtgcgtgcc aacattgctg ccatcactga atcagacaag
961 ttcttcatca acggctccaa ctgggaaggc atcctggggc tggcctatgc tgagattgcc
1021 aggcctgacg actccctgga gcctttcttt gactctctgg taaagcagac ccacgttccc
1081 aacctcttct ccctgcagct ttgtggtgct ggcttccccc tcaaccagtc tgaagtgctg
1141 gcctctgtcg gagggagcat gatcattgga ggtatcgacc actcgctgta cacaggcagt
1201 ctctggtata cacccatccg gcgggagtgg tattatgagg tgatcattgt gcgggtggag
1261 atcaatggac aggatctgaa aatggactgc aaggagtaca actatgacaa gagcattgtg
1321 gacagtggca ccaccaacct tcgtttgccc aagaaagtgt ttgaagctgc agtcaaatcc
1381 atcaaggcag cctcctccac ggagaagttc cctgatggtt tctggctagg agagcagctg
1441 gtgtgctggc aagcaggcac caccccttgg aacattttcc cagtcatctc actctaccta
1501 atgggtgagg ttaccaacca gtccttccgc atcaccatcc ttccgcagca atacctgcgg
1561 ccagtggaag atgtggccac gtcccaagac gactgttaca agtttgccat ctcacagtca
1621 tccacgggca ctgttatggg agctgttatc atggagggct tctacgttgt ctttgatcgg
1681 gcccgaaaac gaattggctt tgctgtcagc gcttgccatg tgcacgatga gttcaggacg
1741 gcagcggtgg aaggcccttt tgtcaccttg gacatggaag actgtggcta caacattcca
1801 cagacagatg agtcaaccct catgaccata gcctatgtca tggctgccat ctgcgccctc
1861 ttcatgctgc cactctgcct catggtgtgt cagtggcgct gcctccgctg cctgcgccag
1921 cagcatgatg actttgctga tgacatctcc ctgctgaagt gaggaggccc atgggcagaa
1981 gatagagatt cccctggacc acacctccgt ggttcacttt ggtcacaagt aggagacaca
2041 gatggcacct gtggccagag cacctcagga ccctccccac ccaccaaatg cctctgcctt
2101 gatggagaag gaaaaggctg gcaaggtggg ttccagggac tgtacctgta ggaaacagaa
2161 aaaaaaaaaa aaaa
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