LOCUS BC036032 3757 bp mRNA linear HUM 11-AUG-2006
DEFINITION Homo sapiens mitogen-activated protein kinase kinase 4, mRNA (cDNA
clone MGC:33126 IMAGE:5272439), complete cds.
ACCESSION BC036032
VERSION BC036032.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3757)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3757)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (31-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 48 Row: d Column: 13
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 24497520.
FEATURES Location/Qualifiers
source 1..3757
/db_xref="H-InvDB:HIT000094222"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:33126 IMAGE:5272439"
/tissue_type="Testis"
/clone_lib="NIH_MGC_97"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..3757
/gene="MAP2K4"
/gene_synonym="JNKK"
/gene_synonym="JNKK1"
/gene_synonym="MAPKK4"
/gene_synonym="MEK4"
/gene_synonym="MKK4"
/gene_synonym="PRKMK4"
/gene_synonym="SEK1"
/db_xref="GeneID:6416"
/db_xref="HGNC:HGNC:6844"
/db_xref="MIM:601335"
CDS 70..1269
/gene="MAP2K4"
/gene_synonym="JNKK"
/gene_synonym="JNKK1"
/gene_synonym="MAPKK4"
/gene_synonym="MEK4"
/gene_synonym="MKK4"
/gene_synonym="PRKMK4"
/gene_synonym="SEK1"
/codon_start=1
/product="mitogen-activated protein kinase kinase 4"
/protein_id="AAH36032.1"
/db_xref="GeneID:6416"
/db_xref="HGNC:HGNC:6844"
/db_xref="MIM:601335"
/translation="MAAPSPSGGGGSGGGRGSGTPGPVGSPAPGHPAVSSMQGKRKAL
KLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDL
KDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPY
IVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH
LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID
PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEER
EFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATP
SSPMYVD"
BASE COUNT 1103 a 788 c 796 g 1070 t
ORIGIN
1 ggccgtgcga gaggccgagc ttgctgcatt gcagccgccg cggcgccgct cggctcttca
61 ctcccaacaa tggcggctcc gagcccgagc ggcggcggcg gctccggggg cggccgcggc
121 agcggcaccc ccggccccgt agggtccccg gcgccaggcc acccggccgt cagcagcatg
181 cagggtaaac gcaaagcact gaagttgaat tttgcaaatc cacctttcaa atctacagca
241 aggtttactc tgaatcccaa tcctacagga gttcaaaacc cacacataga gagactgaga
301 acacacagca ttgagtcatc aggaaaactg aagatctccc ctgaacaaca ctgggatttc
361 actgcagagg acttgaaaga ccttggagaa attggacgag gagcttatgg ttctgtcaac
421 aaaatggtcc acaaaccaag tgggcaaata atggcagtta aaagaattcg gtcaacagtg
481 gatgaaaaag aacaaaaaca acttcttatg gatttggatg tagtaatgcg gagtagtgat
541 tgcccataca ttgttcagtt ttatggtgca ctcttcagag agggtgactg ttggatctgt
601 atggaactca tgtctacctc gtttgataag ttttacaaat atgtatatag tgtattagat
661 gatgttattc cagaagaaat tttaggcaaa atcactttag caactgtgaa agcactaaac
721 cacttaaaag aaaacttgaa aattattcac agagatatca aaccttccaa tattcttctg
781 gacagaagtg gaaatattaa gctctgtgac ttcggcatca gtggacagct tgtggactct
841 attgccaaga caagagatgc tggctgtagg ccatacatgg cacctgaaag aatagaccca
901 agcgcatcac gacaaggata tgatgtccgc tctgatgtct ggagtttggg gatcacattg
961 tatgagttgg ccacaggccg atttccttat ccaaagtgga atagtgtatt tgatcaacta
1021 acacaagtcg tgaaaggaga tcctccgcag ctgagtaatt ctgaggaaag ggaattctcc
1081 ccgagtttca tcaactttgt caacttgtgc cttacgaagg atgaatccaa aaggccaaag
1141 tataaagagc ttctgaaaca tccctttatt ttgatgtatg aagaacgtgc cgttgaggtc
1201 gcatgctatg tttgtaaaat cctggatcaa atgccagcta ctcccagctc tcccatgtat
1261 gtcgattgat atcgctgcta catcagactc tagaaaaaag ggctgagagg aagcaagacg
1321 taaagaattt tcatcccgta tcacagtgtt tttattgctc gcccagacac catgtgcaat
1381 aagattggtg ttcgtttcca tcatgtctgt atactcctgt cacctagaac gtgcatcctt
1441 gtaatacctg attgatcaca cagtgttagt gctggtcaga gagacctcat cctgctcttt
1501 tgtgatgaac atattcatga aatgtggaag tcagtacgat caagttgttg actgtgatta
1561 gatcacatct taaattcatt tctagactca aaacctggag atgcagctac tggaatggtg
1621 ttttgtcaga cttccaaatc ctggaaggac acagtgatga atgtactatg tctgaacata
1681 gaaactcggg cttgagtgag aagagcttgc acagccaacg agacacattg ccttctggag
1741 ctgggagaca aaggaggaat ttactttctt caccaagtgc aatagattac tgatgtgata
1801 ttctgttgct ttacagttac agttgatgtt tggggatcga tgtgctcagc caaatttcct
1861 gtttgaaata tcatgttaaa ttagaatgaa tttatcttta ccaaaaacca tgttgcgttc
1921 aaagaggtga acattaaaat atagagacag gacagaatgt gttcttttct cctttaccag
1981 tcctattttt caatgggaag actcaggagt ctgccacttg tcaaagaagg tgctgatcct
2041 aagaattttt cattctcaga attcggtgtg ctgccaactt gatgttccac ctgccacaaa
2101 ccaccaggac tgaaagaaga aaacagtaca gaaggcaaag tttacagatg tttttaattc
2161 tagtatttta tctggaacaa cttgtagcag ctatatattt ccccttggtc ccaagcctga
2221 tactttagcc atcataactc actaacaggg agaagtagct agtagcaatg tgccttgatt
2281 gattagataa agatttctag taggcagcaa aagaccaaat ctcagttgtt tgcttcttgc
2341 catcactggt ccaggtcttc agtttccgaa tctctttccc ttcccctgtg gtctattgtc
2401 gctatgtgac ttgcgcttaa tccaatattt tgcctttttt ctatatcaaa aaacctttac
2461 agttagcagg gatgttcctt accaaggatt tttagcccca aatctctcat attcgctagt
2521 gtttaaaagg ctaagaatag tggggcccag ccgatgtggt aggtgataaa gaggcatctt
2581 ttctagagac acattgaacc agatgaggat ccgaaacggc agcctttacg ttcatcacct
2641 gctagaacct ctcgtagtcc atcaccattt cttggcattg gaattctact ggaaaaaaat
2701 acaaaaagca aaacaaaacc ctcagcactg ttacaagagg ccatttaagt atcttgtgct
2761 tcttcactta cccattagcc aggttctcat taggttttgc ttgggcctcc ctggcactga
2821 accttaggct ttgcatgaca gtgaagcagc actgtgagtg gttcaagcac actggaatat
2881 aaaacagtca tggcctgaga tgcaggtgat gccattacag aaccaaatcg tggcacgtat
2941 tgctgtgtct cctctcagag tgacagtcat aaatactgtc aaacaataaa gggagaatgg
3001 tgctgtttaa agtcacatcc ctgtaaattg cagaattcaa aagtgattat ctctttgatc
3061 tacttgcctc atttccctat cttctccccc acggtatcct aaactttaga cttcccactg
3121 ttctgaaagg agacattgct ctatgtctgc cttcgaccac agcaagccat catcctccat
3181 tgctcccggg gactcaagag gaatctgttt ctctgctgtc aacttcccat ctggctcagc
3241 atagggtcac tttgccatta tgcaaatgga gataaaagca attctgactg tccaggagct
3301 aatctgaccg ttctattgtg tggatgacca cataagaagg caattttagt gtattaatca
3361 tagattatta taaactataa acttaagggc aaggagttta ttacaatgta tctttattaa
3421 aacaaaaggg tgtatagtgt tcacaaactg tgaaaatagt gtaagaactg tacattgtga
3481 gctctggtta tttttctctt gtaccataga aaaatgtata aaaattatca aaaagctaat
3541 gtgcagggat attgccttat ttgtctgtaa aaaatggagc tcagtaacat aactgcttct
3601 tggagctttg gaatatttta tcctgtattc ttgtttgaat tcctcctcta tttaagatat
3661 atacatggaa tcgaagtgtt tatgtaatag ttctatcctt ttgcctgcag gtcagttgta
3721 ataaatctag gatgtgatga agaaaaaaaa aaaaaaa
//